A neuromimetic stimulating apparatus includes a feedback detector configured to detect a feedback signal from a target to be stimulated, a controller configured to analyze a waveform of the detected feedback signal and determine a parameter based on the analyzed waveform of the detected feedback signal, and a signal generator configured to generate a stimulus signal corresponding to the detected feedback signal based on the determined parameter.

An example method includes establishing a communications link between an electrophysiology (EP) monitoring system and an implantable medical device (IMD). IMD electrical data is received at the monitoring system via the communications link. The IMD electrical data may be synchronized with EP measurement data to provide synchronized electrical data based on timing of a synchronization signal sensed by an IMD electrode and/or EP electrodes. The method also includes computing reconstructed electrical signals for locations on a surface of interest within the patient's body based on the synchronized electrical data and geometry data. The geometry data represents locations of the EP electrodes, a location of the IMD electrode within the patient's body and the surface of interest.

An example method includes establishing a communications link between an electrophysiology (EP) monitoring system and an implantable medical device (IMD). IMD electrical data is received at the monitoring system via the communications link. The IMD electrical data may be synchronized with EP measurement data to provide synchronized electrical data based on timing of a synchronization signal sensed by an IMD electrode and/or EP electrodes. The method also includes computing reconstructed electrical signals for locations on a surface of interest within the patient's body based on the synchronized electrical data and geometry data. The geometry data represents locations of the EP electrodes, a location of the IMD electrode within the patient's body and the surface of interest.

The present invention relates to non-excitatory electrical heart failure therapy as a therapy for Heart failure with preserved ejection fraction.

Systems and methods for managing heart failure are described. The system receives physiological information including a first HS signal corresponding to paced ventricular contractions and a second HS signal corresponding to intrinsic ventricular contractions. The system detects worsening heart failure (WHF) using the received physiological information. A signal analyzer circuit can generate a paced HS metric from the first HS signal and a sensed HS metric from the second HS signal, and determine a concordance indicator between the paced and the sensed HS metrics. In response to the detected WHF, the system can use the concordance indicator to generate a therapy adjustment indicator for adjusting electrostimulation therapy, or a worsening cardiac contractility indicator indicating the detected WHF is attributed to degrading myocardial contractility.

This document describes methods and materials for improving the delivery of electroporation. For example, this document describes methods and devices for delivering electroporation while mitigating risks of ventricular fibrillation.

A cardiac pacing system that includes an implantable pulse generator and electrical leads that include a lead body portion having a distal end and a proximal end, a connector configured to electrically connect the proximal end of the lead body to the pulse generator, and at least one electrode disposed at the distal end of the lead body for delivering electrical stimulation to a patient's heart, wherein the distal end of the lead body is configured to terminate within the mediastinum of the thoracic cavity of the patient, proximate to the heart.

A cardiac pacing system that includes an implantable pulse generator and electrical leads that include a lead body portion having a distal end and a proximal end, a connector configured to electrically connect the proximal end of the lead body to the pulse generator, and at least one electrode disposed at the distal end of the lead body for delivering electrical stimulation to a patient's heart, wherein the distal end of the lead body is configured to terminate within the mediastinum of the thoracic cavity of the patient, proximate to the heart.

Subcutaneous implantable string shaped defibrillator for providing cardiac resynchronization therapy (CRT), including a flexible elongated body, at least two defibrillation leads, at least one sensor, at least two transition units and at least one epicardial lead, the defibrillation leads for providing at least one cardioversion defibrillation shock, the sensor being positioned on at least one of the defibrillation leads, for determining at least one metric of a heart, the transition units for respectively coupling the defibrillation leads to opposite ends of the elongated body, and the epicardial lead, coupled with the elongated body via at least one of the transition units, for providing at least one CRT pulse, the elongated body including a plurality of linked units, the linked units encapsulating at least one capacitor, at least one power source and a processor, wherein the processor provides at least one signal to the epicardial lead for providing the CRT pulse.

Subcutaneous implantable string shaped defibrillator for providing cardiac resynchronization therapy (CRT), including a flexible elongated body, at least two defibrillation leads, at least one sensor, at least two transition units and at least one epicardial lead, the defibrillation leads for providing at least one cardioversion defibrillation shock, the sensor being positioned on at least one of the defibrillation leads, for determining at least one metric of a heart, the transition units for respectively coupling the defibrillation leads to opposite ends of the elongated body, and the epicardial lead, coupled with the elongated body via at least one of the transition units, for providing at least one CRT pulse, the elongated body including a plurality of linked units, the linked units encapsulating at least one capacitor, at least one power source and a processor, wherein the processor provides at least one signal to the epicardial lead for providing the CRT pulse.