Systems, methods, and devices are described herein for determining cardiac conduction system capture of ventricle from atrium (VfA) therapy. VfA therapy may be delivered at a plurality of different A-V delays while electrical activity of the patient is monitored. The electrical activity may then be utilized to determine whether the cardiac conduction system of the patient has been captured by the VfA therapy.

A medical system includes an implantable medical device configured to be positioned within an atrium of a heart. The implantable medical device includes a housing carrying a return electrode, a first leadlet, a second leadlet, and a fixation device. The medical system may be configured to deliver a variety of therapies, including one or more of ventricle-from-atrium cardiac therapy (“VfA therapy”), left bundle branch pacing therapy (“LBB therapy”), or cardiac resynchronization therapy (“CRT”).

Methods and apparatuses for stimulation of the vagus nerve to treat inflammation including adjusting the stimulation based on one or more metric sensitive to patient response. The one or more metrics may include heart rate variability, level of T regulatory cells, particularly memory T regulatory cells, temperature, etc. Stimulation may be provided through an implantable microstimulator.

A kit comprises a device (1) for electrotherapy and/or electrophysiology and a delivery system and method for the device. The device (1) includes a lead (2) and a paddle (5) comprising at least one electrode (8), the paddle (5) being reconfigurable between an operative configuration and a transport configuration of smaller transverse extent. The delivery system comprises a flexible, hollow outer sheath (28) and a hollow delivery sheath (100) for receiving at least the paddle (5) of the device (1) in the transport configuration. The delivery sheath (100) may be inserted into a proximal end of the outer sheath (28) and transported through the outer sheath (28) to deliver the paddle (5) of the device (1) to a distal end of the outer sheath (28), which is located at or directed towards an implantation site in the body (11) of a patient. The delivery sheath (100) protects the paddle (5) during transport and permits enhanced control of the position and orientation of the paddle (5) when it is deployed.

Systems and methods involving implants positioned within implant pockets through minimally invasive entrance incisions, along with related implants. In some implementations, implants may be folded, rolled, or otherwise compressed to fit within subcutaneous implant pockets, after which they may be decompressed to fit within an implant pocket having one or more dimensions substantially larger than the entrance incision. Such implants may be used for a variety of purposes, including generating electrical energy for various other implants located throughout the body.

Systems and methods involving implants positioned within implant pockets through minimally invasive entrance incisions, along with related neurostimulatory implants. In some implementations, implants may be folded, rolled, or otherwise compressed to fit within subcutaneous implant pockets, after which they may be decompressed to fit within an implant pocket having one or more dimensions substantially larger than the entrance incision. Such implants may be used for a variety of purposes, including generating electrical energy for various other implants, including neurostimulatory implants located throughout the body.

An electrical feedthrough assembly, which is configured to be mounted on a housing of a leadless biostimulator, comprises an electrode body including a cup having an electrode wall extending distally from an electrode base around an electrode cavity, an electrode tip mounted on a distal end of the electrode body, and a filler in the electrode cavity between the electrode base and the electrode tip, wherein the filler includes a therapeutic agent. The electrode tip is configured to be placed in contact with target tissue to which a pacing impulse is to be transmitted by the leadless biostimulator. A pin extends proximally from the electrode base, wherein the pin is configured to be into contact with an electrical connector of an electronics assembly within the housing of the leadless biostimulator.

The implant comprises a tubular body housing an energy harvesting module adapted to convert external stresses applied to the implant into electrical energy, and a rechargeable battery adapted to be charged by the energy harvesting module. During the storage, an external source physically separated from the implant is coupled to the implant rechargeable battery to maintain a minimum battery charge level. An interface circuit of the implant couples surface electrodes to the battery, with switching between: i) a transport and storage configuration where the electrodes are connected to the external source to receive from the latter a battery charging energy and/or to exchange communication signals with the outside through the wire link of the coupling; and ii) a functional configuration in which the surface electrodes are decoupled from the external source after the implant has been implanted. The implant further comprises a data transmitter circuit adapted, in the transport and storage configuration, to send communication signals, via the surface electrodes, on the link coupling to the external source, and/or a data receiver circuit adapted, in the transport and storage configuration, to receive, via the surface electrodes, communication signals transmitted on the link coupling to the external source.

An example method includes establishing a communications link between an electrophysiology (EP) monitoring system and an implantable medical device (IMD). IMD electrical data is received at the monitoring system via the communications link. The IMD electrical data may be synchronized with EP measurement data to provide synchronized electrical data based on timing of a synchronization signal sensed by an IMD electrode and/or EP electrodes. The method also includes computing reconstructed electrical signals for locations on a surface of interest within the patient's body based on the synchronized electrical data and geometry data. The geometry data represents locations of the EP electrodes, a location of the IMD electrode within the patient's body and the surface of interest.

Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include an intermediate tubular member and an inner tubular member slidably disposed within a lumen of the intermediate tubular member. A distal holding section may extend distally of a distal end of the intermediate tubular member and define a cavity therein for receiving an implantable leadless pacing device. The device may be configured to enable fluid flushing of the delivery device prior to use, to remove any air from within the device as well as providing the option of fluid flow during use of the delivery device.