Conventional single fraction 20-Gy broadbeam photonbeam or protonbeam chemo-radiosurgery does not sterilize EMT-MET cancer stem cell radiodurans but single fraction 100 to 10,000 Gy microbeam radiosurgery sterilizes them. Device and methods for microbeam chemo-radiosurgery including 250 MeV wakefield electronbeam is disclosed.

Surgery, chemotherapy and broadbeam and microbeam radiosurgery releases billions of abscopal metastasis causing, tumor specific plasma soluble proteins, cell membranes, apoptotic bodies, DNA and RNAs, exosomes like telomere-telomerase, ATM-ATM kinase and others. They and adaptive resistance to chemo-radiosurgery, paraneoplastic and non-paraneoplastic diseases causing immune complexes are removed by pulse flow combined continuous flow ultracentrifugation apheresis and immune affinity chromatography. Chemotherapy and high dose radiation exposed tumor cells and their exosomes are made sensitive to telomerase inhibiting and apoptosis inducing and least toxic epigallocatechin and to heparin bound receptors. They convert triple negative breast tumors into receptor positive tumors which open new avenues for treating most aggressive breast cancers.

Described herein is a system and method of controlling real-time image-guided adaptive radiation treatment of at least a portion of a region of a patient. The computer-implemented method comprises obtaining a plurality of real-time image data corresponding to 2-dimensional (2D) magnetic resonance imaging (MRI) images including at least a portion of the region, performing 2D motion field estimation on the plurality of image data, approximating a 3-dimensional (3D) motion field estimation, including applying a conversion model to the 2D motion field estimation, determining at least one real-time change of at least a portion of the region based on the approximated 3D motion field estimation, and controlling the treatment of at least a portion of the region using the determined at least one change.

Apparatus and techniques are described herein for nuclear magnetic resonance (MR) projection imaging. Such projection imaging may be used to control radiation therapy delivery to a subject, such as including receiving reference imaging information, generating a two-dimensional (2D) projection image using imaging information obtained via nuclear magnetic resonance (MR) imaging, the 2D projection image corresponding to a specified projection direction, the specified projection direction including a path traversing at least a portion of an imaging subject, determining a change between the generated 2D projection image and the reference imaging information, and controlling delivery of the radiation therapy at least in part using the determined change between the obtained 2D projection image and the reference imaging information.

A radiotherapy equipment control device acquires reference position information for a specific location at a reference time. Furthermore, representative point reference position information is generated from reference position information for a plurality of markers at the reference time, and relative position information up to the reference position information for the specific location is generated. Moreover, representative point position information at another time is generated from the position information for a plurality of markers in a subject at the other time, which differs from the reference time. In addition, position information for the specific location at the other time is generated from the representative point position information and the relative position information. In this case, representative point reference position information and representative position information are generated on the basis of the position information and reference position information for the plurality of markers, said information having been weighted by weighting factors.

A system for treating a patient during radiation therapy is disclosed. The system includes a shell, a plurality of material inserts disposed in the shell, where each material insert of the plurality of material inserts respectively shapes a distribution of a dose delivered to the patient by a respective beam of a plurality of beams emitted from a nozzle of a radiation treatment system, and a scaffold component disposed in the shell that holds the plurality material inserts in place relative to the patient such that each material insert lies on a path of at least one of the beams.

According to one embodiment, A movable part tracking and treatment apparatus, includes: an acquisition unit adapted to acquire a three-dimensional moving image by imaging an inside of a body of a patient; a first projection image generation unit adapted to generate a first projection moving image by projecting the three-dimensional moving image on a two-dimensional surface from a fixed direction, the three-dimensional moving image including a tracing target and an affected part area that are part of internal organs in a displaced state, an affected part image extraction unit adapted to extract the displaced affected part area from the first projection moving image, a tracing target image extraction unit adapted to extract the displaced tracing target from the first projection moving image, a first parameter derivation unit is adapted to derive a first parameter indicative of position information on a beam irradiation point selected from the displaced affected part area in the first projection moving image, and a second parameter derivation unit adapted to derive a second parameter necessary to extract the corresponding tracing target from another projection moving image based on the tracing target extracted from the first projection moving image.

Methods, apparatuses and systems are disclosed for dose-based optimization related to multi-leaf collimator (“MLC”) tracking during radiation therapy. In an example, a method includes calculating a planned radiation dose using an MLC plan in an unshifted dose volume, acquiring, using a radiation machine, a target position through motion tracking, and shifting the dose volume by the target position. The method also includes integrating a three-dimensional dose into a two-dimensional beam’s eye view grid and fitting, using the radiation machine for each leaf track, an MLC aperture by minimizing a cost function. The method further includes calculating and accumulating a delivered dose based on the fitted leaf positions of the MLC and updating a gantry position and MLC leaves to update a next planned dose.

The disclosure provides a system for EGRT. The system may include a radiotherapy device for treating a subject. The radiotherapy device may include a scintillation camera that is directed at an ROI of the subject. The subject may be injected with a radioactive tracer or implanted with a radioactive marker before treatment. The ROI may undergo a physiological motion during the treatment. The system may deliver a treatment session to the subject by the radiotherapy device. During the treatment session, the system may acquire a target image of the ROI indicative of a distribution of the radioactive tracer or the radioactive maker in the ROI by the scintillation camera, and adapt a radiation beam to be delivered to the subject with respect to the physiological motion of the ROI by adjusting the radiation beam based on the target image.

An irradiation apparatus radiates a particle beam after forming the beam for plural layers. A dose monitor measures a dose in real time. A dose evaluation unit evaluates an irradiation dose for each layer on the basis of a value measured by the dose monitor and a dose calibration factor set for each layer. An irradiation control section performs radiation control for each layer on the basis of an evaluation result of the dose evaluation unit. An interpolation value generation unit uses actual-measurement dose-calibration factors obtained by radiating a particle beam to a simulated phantom provided with a calibration dosimeter, to generate an interpolation estimation value of the dose calibration factor. For each layer subject to the interpolation value, and based on an irradiation condition of that layer, the interpolation value generation unit performs weighting on each of the actual-measurement dose-calibration factors.

A radiotherapy apparatus is disclosed, with a linear accelerator for producing a beam of electrons, a target aligned with the electron beam, the target being capable of producing photons when electrons are incident thereon, and a material which is capable of producing neutrons when photons of sufficient energy are incident thereon. A neutron detector capable of providing a signal to a controller of the linear accelerator is provided, the controller being capable of varying the energy of the electrons of the electron beam.