Blood sampling device comprising a lancet body supporting a lancet tip, said lancet being moveably mounted within a housing, an urging member configured to urge said lancet forwardly in said housing in use from a primed position in which said lancet tip is located within a passage to a lancing position in which said lancet tip projects through an aperture in the forward end of the housing and a removable safety cap. The housing and said safety cap comprise cooperating abutment surfaces and cooperating stop surfaces, with the safety cap being rotatable in a first direction from a first blocked position in which said cooperating abutment surfaces are in abutment alignment to prevent removal of said safety cap from said housing to a second position in which said cooperating abutment surfaces are not in abutment alignment such that said safety cap can be removed from said housing; and wherein said stop surfaces cooperate to limit further rotation of said safety cap in said first direction when said safety cap is in said second position.

Embodiments of the present invention provide magnetic lancet devices and methods for driving a lancet. For example, a magnetic lancet device may include a driving mechanism having a plurality of magnets and a lancet coupled to the driving mechanism. A magnetic interaction between the plurality of magnets is configured to drive the lancet from an engaged position to a penetrating position.

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

Devices and methods for withdrawing bodily fluid from a subject are disclosed herein. In some embodiments, a handheld device can include a housing having an opening, a skin-piercing assembly, and an actuator coupled to the skin-piercing assembly. The skin-piercing assembly can include a casing, a drive member pivotably mounted within the casing and carrying a blade, and a biasing member coupling the drive member to the casing. The actuator can be movable relative to the housing from a first position to a second position. In the first position, the drive member can engage the casing to maintain the biasing member in a biased configuration. Movement of the actuator from the first position to the second position can disengage the drive member from the casing to permit the biasing member to drive the blade at least partially through and/or across the opening in the base.

A device for collecting a physiological sample from a subject includes a lancet with a needle that is configured to puncture the subject’s skin and a cartridge configured to engage with the lancet. The lancet is configured to transition the needle from an undeployed position to a deployed position in response to engagement with the cartridge, thereby allowing the needle to puncture the subject’s skin.

A dermal patch system for collecting a physiological sample includes a cartridge configured to attach to the skin of a subject. The cartridge includes a bottom material layer, a middle material layer, a top material layer, and a sample collection pad. The top layer and the middle layer define a vacuum pin receptacle and the vacuum pin is disposed within the vacuum pin receptacle. The vacuum pin creates a vacuum within the cartridge when moved to a deployed position. The system further includes a lancet with a needle(s). The lancet is configured to move the needle(s) from an undeployed position to a deployed position when engaged with into the cartridge. The needle(s) is configured to draw a physiological sample from the subject when the needle(s) is in the deployed position. The vacuum created by the vacuum pin draws the physiological sample to the sample collection pad.

A lancing device including a latch that pivots between a non-blocking position allowing a lancet carrier and a lancet to advance and retract through a first forward and reverse lancing stroke and a blocking position preventing further/excess/secondary oscillation of the lancet carrier and lancet. The pivotal latch can pivot about an axis perpendicular (e.g., for an L-shaped latch) or parallel/coaxial (e.g., for a sleeve latch) to the advancement and retraction motion of the lancet carrier and lancet.

The present disclosure relates to a blood collection device, including: a shell; a blade seat, arranged in the shell; an elastic component for providing an elastic force for pivoting the blade seat; a triggering portion, including an operating end and an abutting end, wherein the triggering portion has a first position and a second position for pivoting, the operating end extends to the outside of the shell, the abutting end is located in the shell, based on the operation of the operating end, the triggering portion is suitable for pivoting from the first position that prevents the blade seat from pivoting to the second position that allows the blade seat to pivot based on the elastic force of the elastic component, wherein: a cooperation column is arranged in the shell and is located at the upper side of the triggering portion spaced from the triggering portion; and an elastic arm is connected to the upper side of the triggering portion, the end part of the elastic arm includes a blocking portion, the end part of the elastic arm is suitable for being located on one side of the cooperation column when the triggering portion is at the first position, and is located on the other side of the cooperation column when the triggering portion pivots from the first position to the second position, and the blocking portion provides resistance for the end part of the elastic arm while moving from one side of the cooperation column to the other side.

A device for collecting a physiological sample from a subject includes a lancet and a cartridge configured to couple to the lancet. The needle is configured to puncture the subject's skin. The lancet is configured to automatically deploy the needle when coupled to the lancet which allows the needle to puncture the subject's skin and draw a physiological sample. The device further includes a vial disposed within the cartridge. The vial is configured to receive the drawn physiological sample.

A handheld lancing device having anesthetic feature includes a housing removably retaining a disposable lancet. A carriage suspended within the housing by an isolation assembly may receive the lancet. A motor in mechanical communication with the lancet produces vibrations transmitted to contact surface, which vibrate a target lancing site prior to and during piercing. The target site is vibrated for a predetermined period of time before deploying the lancet. The isolation assembly permits movement of the carriage and/or lancet within the housing in one direction while limiting movement in other directions, and further dampens the vibrations of the motor from the housing held by the user. A force sensor detects force applied by the pressing of the contact surface against the skin of the patient. An indicator(s) perceivable to the user identifies when predefined positions of the lancet are reached for initiating vibration then triggering the lancet.