In some embodiments, a body cavity shape of a subject is reconstructed based on intrabody measurements of voltages by an intrabody probe (for example, a catheter probe) moving within a plurality of differently-oriented electromagnetic fields crossing the body cavity. In some embodiments, the method uses distances between electrodes as a spatially calibrated ruler. Positions of measurements made with the intrabody probe in different positions are optionally related by using spatial coherence of the measured electromagnetic fields as a constraint. Optionally, reconstruction is performed without using a detailed reference (image or simulation) describing the body cavity shape. Optionally, reconstruction uses further information to refine and/or constrain the reconstruction; for example: images, simulations, additional electromagnetic fields, and/or measurements characteristic of body cavity landmarks. Optionally, reconstruction accounts for time-dependent cavity shape changes, for example, phasic changes (e.g., heartbeat and/or respiration), and/or changes in states such as subject hydration, edema, and/or heart rate.

A system for obtaining signals related to electrical activity of the heart of a subject includes a sensing device including an elongate member having a distal end configured for placement within a body lumen of a subject, and a proximal end configured to extend from the subject, an actuation portion carried by the elongate member and configured for placement within the body lumen, the actuation portion having a low-profile state for delivery within the body lumen and an expanded state, and one or more sensors disposed on the actuation portion, each including a contact surface configured to contact an interior wall of the body lumen, wherein the actuation portion is configured to cause the contact surface of each of the one or more sensors to contact a location on the interior wall of the body lumen to provide a signal component for producing one or more electrocardiogram signals.

A system for obtaining signals related to electrical activity of the heart of a subject includes a sensing device including an elongate member having a distal end configured for placement within a body lumen of a subject, and a proximal end configured to extend from the subject, an actuation portion carried by the elongate member and configured for placement within the body lumen, the actuation portion having a low-profile state for delivery within the body lumen and an expanded state, and one or more sensors disposed on the actuation portion, each including a contact surface configured to contact an interior wall of the body lumen, wherein the actuation portion is configured to cause the contact surface of each of the one or more sensors to contact a location on the interior wall of the body lumen to provide a signal component for producing one or more electrocardiogram signals.

A system for obtaining signals related to electrical activity of the heart of a subject includes a sensing device including an elongate member having a distal end configured for placement within a body lumen of a subject, and a proximal end configured to extend from the subject, an actuation portion carried by the elongate member and configured for placement within the body lumen, the actuation portion having a low-profile state for delivery within the body lumen and an expanded state, and one or more sensors disposed on the actuation portion, each including a contact surface configured to contact an interior wall of the body lumen, wherein the actuation portion is configured to cause the contact surface of each of the one or more sensors to contact a location on the interior wall of the body lumen to provide a signal component for producing one or more electrocardiogram signals.

An instrument for internal mapping includes a flexible elongated portion (702) and an expandable portion (710) coupled distally to the elongated portion, the expandable portion having one or more expandable loops. An array of sensors (706) and electrodes (708) is distributed on the expandable portion and is configured to concurrently register the instrument to real-time images of an anatomy using the sensors and measure electrical characteristics of the anatomy with the electrodes to generate an electro-physiology (EP) map having the anatomy and intensities of the electrical characteristics mapped together in the real-time images.

There is provided a system for managing reflux during an enteral feeding, comprising: (i) a non-transitory memory having stored thereon a code for execution by at least one hardware processor of a computing device, the code comprising: code for receiving electrical signals outputted by at least one reflux event sensor disposed within a digestive system of a patient; code for determining a gastric reflux event based on an analysis of the electrical signals; code for outputting instructions to pause enteral feeding of the patient by a feeding controller that regulates enteral feeding of the patient using an enteral feeding tube positioned within the digestive system of the patient; and (ii) an evacuation controller that directs back-flow of digestive contents from the digestive system of the patient to an external evacuation reservoir through an evacuation tube.

A system and method for monitoring a patient's compliance with a medication regimen includes an electronic tag integral with or attached to a medicine delivery device such as a capsule, the tag having an antenna and a receiver/transmitter, the system also including a reader positioned externally for detecting the presence and location of the delivery device in the patient.

Devices, systems and methods useable for useable for monitoring a physiological variable in a target tissue or body fluid located within the thorax of a subject by optical spectroscopy.

A system for performing a diagnostic or therapeutic procedure within a subject includes a device having a distal portion configured for insertion within a lumen or duct of the subject, the device including an elongate body having a longitudinal axis, the elongate body comprising a polymeric material and having a proximal end and a distal end, one or more electrically-conductive tracings carried on a first surface of the elongate body and configured to carry a signal, and one or more conductors embedded within the polymeric material and configured to carry a signal.

An apparatus for monitoring EMG signals of a patient's laryngeal muscles includes an endotracheal tube having an exterior surface. Conductive electrodes are formed on the endotracheal tube. The conductive electrodes are configured to receive the EMG signals from the laryngeal muscles when the endotracheal tube is placed in a trachea of the patient. At least wireless sensor is formed on the endotracheal tube, and is configured to wirelessly transmit information to a processing apparatus.