The apparatus for calculating blood pressure using a digital ECG voltage coordinate value comprising an X coordinate of a time axis and a Y coordinate of a heart voltage signal intensity axis, the apparatus comprising an acquiring unit for acquiring a target digital ECG voltage coordinate value of the measurement subject, and an arithmetic unit for calculating a systolic blood pressure and a diastolic blood pressure by comparing previously stored reference digital ECG voltage coordinate values and acquired digital ECG voltage coordinate values, respectively. the acquired target digital ECG voltage coordinate value includes: a specific coordinate value (Q.sub.PT value) representing an inflection point of a Q waveform; a specific coordinate value (R.sub.PT value) representing an inflection point of an R waveform; a specific coordinate value (T.sub.PT value) representing an inflection point of a T waveform; and a specific coordinate value (S.sub.PT value) representing an inflection point of an S waveform.

Methods and devices are disclosed for puncturing tissue, comprising a puncture device for puncturing tissue and a supporting member for supporting the puncture device. The puncture device is capable of being insertable within the supporting member and being selectively usable in co-operation therewith during a portion of a procedure for puncturing tissue and wherein the puncture device is usable independently therefrom during another portion of the procedure. The puncture device comprises visual or tactile markers for determining the relative positioning between puncture device and supporting member.

Systems and methods are described herein for evaluation and configuration cardiac therapy. The systems and methods may monitor electrical activity using a plurality of external electrodes and may utilize multiple-electrode cardiac metrics such as electrical heterogeneity information, single-electrode cardiac metrics, and vectorcardiographic metrics to determine and select one or more paced settings from a plurality of different paced settings.

Systems and methods are described herein for evaluation and configuration cardiac therapy. The systems and methods may monitor electrical activity using a plurality of external electrodes and may utilize multiple-electrode cardiac metrics such as electrical heterogeneity information, single-electrode cardiac metrics, and vectorcardiographic metrics to determine and select one or more paced settings from a plurality of different paced settings.

Methods and devices are disclosed for puncturing tissue, comprising an assembly for puncturing a target tissue. The puncture device of the assembly has a distal tip configured to puncture the target tissue and at least one proximal marker, formed on the proximal portion of the puncture device. The supporting member of the assembly includes a proximal end, a distal end, and a lumen for receiving the puncture device. The puncture device is configured to enable advancement and withdrawal of the supporting member overtop of the puncture device. Alignment of the proximal end of the supporting member and the at least one proximal marker of the puncture device occurs when the distal tip of the puncture device protrudes from the distal end of the supporting member.

Systems and methods for electrocardiographic waveform analysis, data presentation and actionable alert generation are described. Electrocardiographic waveform data can be received from a wearable device associated with a patient. A mathematical analysis of at least a portion of the electrocardiographic waveform data can be performed to provide cardiac analytics. In instances where (1) a pathologically prolonged QT interval and (2) an R on T premature ventricular contraction and/or a ventricular tachycardia are detected from the cardiac analytics of the at least a portion of the electrocardiographic waveform data, an actionable alert can be generated and displayed with a visualization of the cardiac analytics.

Systems and methods for electrocardiographic waveform analysis, data presentation and actionable alert generation are described. Electrocardiographic waveform data can be received from a wearable device associated with a patient. A mathematical analysis of at least a portion of the electrocardiographic waveform data can be performed to provide cardiac analytics. In instances where (1) a pathologically prolonged QT interval and (2) an R on T premature ventricular contraction and/or a ventricular tachycardia are detected from the cardiac analytics of the at least a portion of the electrocardiographic waveform data, an actionable alert can be generated and displayed with a visualization of the cardiac analytics.

A system is provided for displaying heart graphic information relating to sources and source locations of a heart disorder to assist in evaluation of the heart disorder. A heart graphic display system provides an intra-cardiogram similarity (“ICS”) graphic and a source location (“SL”) graphic. The ICS graphic includes a grid with the x-axis and y-axis representing patient cycles of a patient cardiogram with the intersections of the patient cycle identifiers indicating similarity between the patient cycles. The SL graphic provides a representation of a heart with source locations indicated. The source locations are identified based on similarity of a patient cycle to library cycles of a library cardiogram of a library of cardiograms.

An ambulatory medical device including a plurality of sensing electrodes and one or more processors operably coupled to the plurality of sensing electrodes is provided. Each sensing electrodes is configured to be coupled eternally to a patient and to detect one or more ECG signals. The one or more processors are configured to receive at least one electrode-specific digital signal for each of the plurality of sensing electrodes, determine a noise component for each of the electrode-specific digital signals, analyze each of the noise components for each of the plurality of sensing electrodes, generate electrode matching information for each sensing electrode of the plurality of sensing electrodes based upon analysis of each of the noise components, determine one or more sensing electrode pairs based upon the electrode matching information, and monitor each of the one or more sensing electrode pairs for ECG activity of the patient.

An ambulatory medical device including a plurality of sensing electrodes and one or more processors operably coupled to the plurality of sensing electrodes is provided. Each sensing electrodes is configured to be coupled eternally to a patient and to detect one or more ECG signals. The one or more processors are configured to receive at least one electrode-specific digital signal for each of the plurality of sensing electrodes, determine a noise component for each of the electrode-specific digital signals, analyze each of the noise components for each of the plurality of sensing electrodes, generate electrode matching information for each sensing electrode of the plurality of sensing electrodes based upon analysis of each of the noise components, determine one or more sensing electrode pairs based upon the electrode matching information, and monitor each of the one or more sensing electrode pairs for ECG activity of the patient.