A novel shape memory polymer (SMP)-based device for surgical treatment of an intracorporeal defect (e.g., a void or anomaly) such as an intracranial aneurysm or fistula. In at least one non-limiting embodiment, the SMP device is a 3D-printed SMP material sized to specifically fit and thus occlude an intracranial aneurysm (ICA). The SMP device may be delivered to the intracorporeal defect via a catheter having a heating mechanism wherein the SMP device is raised above its glass transition temperature as it is deployed, causing the SMP device to return to its permanent shape after it is deployed into the intracorporeal defect. SMP device delivery systems that include the SMP devices, as well as methods of making and using the devices and systems, are also disclosed.

Embodiments include, for example, mechanical release systems for implantable medical devices.

A system for deploying a shape memory catheterization device within a patient, includes a catheter for endovascular insertion of the shape memory catheterization device. A heat source heats the shape memory catheterization device above the transition temperature. A transformation data generator includes a circuit driver for driving a circuit that includes at least one resistive element of the shape memory catheterization device and a detection circuit for generating transformation data based on a resistance of the at least one resistive element, wherein the transformation data indicates a shape transformation of the shape memory catheterization device from a catheterization shape to a transformed shape.

A catheter with one or more heated or detachable sections is described. The catheter may be useful for liquid embolic delivery, where the heated or detachable sections may help free the catheter when stuck to liquid embolic during delivery. An instrumented catheter is also described.

A catheter with one or more heated or detachable sections is described. The catheter may be useful for liquid embolic delivery, where the heated or detachable sections may help free the catheter when stuck to liquid embolic during delivery. An instrumented catheter is also described.

A system for occluding a physical anomaly. One embodiment comprises a shape memory material body wherein the shape memory material body fits within the physical anomaly occluding the physical anomaly. The shape memory material body has a primary shape for occluding the physical anomaly and a secondary shape for being positioned in the physical anomaly.

A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.

Disclosed herein are medical devices comprising a single-lobed, thin-walled, expandable body (“ballstent” or “blockstent”) and a flexible, elongated delivery device (“delivery catheter”) and systems and methods of use for treating saccular vascular aneurysms and methods of use for occluding segments of blood vessels and other biological conduits.

Expandable bodies comprising gold, platinum, or silver that can be compressed, positioned in the lumen of an aneurysm or blood vessel, and expanded to conform to the shape of the aneurysm or segment of blood vessel or biological conduit are disclosed. The external surface of the expandable bodies can be configured to promote local thrombosis and to promote the growth of tissue into and around the wall in order to reduce migration of the expandable body and to occlude and seal the aneurysm or biological conduit. The wall of the expandable bodies can also be configured to release drugs or pharmacologically active molecules, such as those that promote thrombosis, cell proliferation, extracellular matrix deposition, or tissue ingrowth.

Treatment of an aneurysm or other vascular defect can be facilitated or enhanced by an implant delivered with a thermally activated detachment system. A delivery system can include an implant with a proximal portion that defines a port. A pusher device can include arms extending distally from a junction of the pusher device and through the port, with distal sections of the arms disposed within the implant. The arms can, at a certain temperature, transition from engagement with the implant to a shape that facilitates release of the implant. Additionally or alternatively, a coil can engage an outer surface of the implant at the proximal portion and transition to a shape that facilitates release of the implant.

A medical device comprising a compressed, inflatable, detachable single-lobed metal balloon attached to a catheter and methods of use for occluding blood vessels or treating vascular aneurysms are disclosed. The balloon can be made with ductile metals such as gold, platinum, or silver so that the balloon will conform to the shape of the void space during inflation and so that the balloon can be subsequently shaped by the application of an external force. The balloon can be configured such that it can be detached from the catheter by physical means or by electrolysis. The surface of the balloon can be configured to promote the growth of tissue into the wall of the balloon and to release drugs or pharmacologically active molecules, so that vessel occlusion or the sealing of an aneurysm will be maintained over time.