The invention relates to a process for manufacturing a monolithic part, wherein different surface topologies are created in specifically selected regions in order to create different surface properties, in particular with respect to a wetting behavior, a deposition behavior and/or a colonization with cells.

Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.

A cosmetic implant includes a silicone gel core and an outermost hydrophilic coating on all sides of the silicone gel core. An intermediate coating can be provided between the silicone gel core and the outermost coating. A method of performing cosmetic surgery on a patient is also disclosed.

The articulating joint prostheses of the invention demonstrate reduced wear and can include a cup (101) formed of UHMWPE. An insert (150) of a hard material, such as metal, ceramic or cross-linked UHMWPE is positioned within the cup at a location of the contact between the cup and head (102). The shape of either component of the kinematic pair may be modified so as to result in an annular surface contact between the two components, with the insert positioned at the annular surface contact. Fluid trapped between the two components within the inner contour of the annular contact area is pressurized under load due to elastic deformation of the components and exuded out through an inter-articular gap over the surface of contact of the insert. This aids lubrication and reduces wear.