An implant is provided for use in an ankle joint between reconditioned end surfaces established on a distal end of an upper tibia bone and an opposing lower talus bone. The implant comprises a substantially porous rigid component adapted to be anchored against the upper tibia reconditioned end surface and the lower talus reconditioned end surface. The component defining an opening therethrough. An intramedullary nail is configured to pass through the opening in the component when the nail is driven through the talus and into the tibia.

Disclosed is a granule made of biocompatible metallic material, in particular made of titanium or titanium alloys, for vertebroplasty operations. The granule has a spherical shape and includes a central core with a solid structure, also spherical, having an outer surface from which a first diametrical rib and a second diametrical rib also having a solid structure, protrude. The ribs are advantageously arranged according to two diameters orthogonal to each other. The granule also includes a portion having a trabeculated structure which extends between the outer surface of the central core and the outer surface of the granule itself.

The invention relates to a prosthesis for implantation into a living body in the form of a magnetic artificial joint, in particular an artificial shoulder joint, comprising: a) a first prosthesis member comprising a socket member, b) a second prosthesis member comprising a head member, c) one of the socket member and the head member is at least partially composed as a permanent magnet and the other one of the socket member and the head member is at least partially composed of a magnetic material, or the socket member and the head member are both at least partially composed as a permanent magnet, d) the socket member comprises a recess on a surface side to be coupled with the head member, the recess comprising a concavely contoured contact surface, e) the head member comprises a projection on a surface side to be coupled with the socket member, the projection comprising a convexly contoured contact surface, f) the convexly contoured contact surface is adapted to the concavely contoured contact surface, such that the head member can be coupled in a rotatably jointed manner to the socket member in the nature of a ball/ball-socket joint, g) wherein the convexly contoured contact surface can perform a generally slip-fee rolling motion or a combined slipping and rolling motion on the concavely contoured contact surface in reaction to a change of an angle between the first and the second prosthesis member, and the convexly contoured contact surface can be shifted across the concavely contoured contact surface within a shifting area.

A prosthetic ankle includes a tibial portion likely to be connected to the lower end of a tibia, a talus portion likely to be connected to a talus, and a pad inserted between the tibial portion and the talus portion. The tibial portion includes an articular surface likely to engage with a contact surface of the pad. The talus portion includes a curved articular surface likely to engage with a contact surface of the pad. The articular surface of the tibial portion is curved, concave and includes a flat section forming an extension to the rear of said articular surface.

A knee prosthesis for total knee replacement has femoral and tibial joint components. The femoral component has a medial condyle, a lateral condyle and an intercondylar recess between the condyles. The condyles have in sagittal profile a spiral outer surface with increasing anterior-to-posterior radii of curvature, such as radii that follow a Fibonacci sequence ratio per every quadrant. The tibial component is lateral-medial mirror symmetric in coronal profile and has shallow concave medial and lateral condyle surfaces for receiving corresponding condyles of the femoral component as bearing surfaces when the femoral and tibial components are biased together under applied tension by ligaments. The shallow concave condyle surfaces in sagittal profile have sharp radii of curvature near anterior and posterior ends of the condyle surfaces that can accommodate up to 5° anterior and up to 6° posterior misplacement error and up to 4° rotational mismatch between the femoral and tibial components.

The invention relates to an implant (1) for introducing into a patient, having an implant body that is at least partially resorbable and is porous at least in some regions and that is made of a ceramic carrier material (2), the carrier material being provided with a donor material (3) that delivers ions to influence the patient's cellular metabolism in the implanted state, the carrier material (2) being interspersed with the donor material (3). The invention also relates to a method for producing an implant (1) of said type.

A tibial component includes a baseplate component that has an articular side and a bone contact side opposite the articular side. A peg extends from the bone contact side such that an acute angle is formed between a longitudinal axis of the peg and the bone contact side of the baseplate component. The peg includes a distal tip, an anterior portion, and a posterior portion. The distal tip defines a first radius of curvature, the anterior portion has a spherical portion that defines a second radius of curvature and extends from the distal tip, and the posterior portion has a conical portion that defines a taper angle relative to a longitudinal axis of the peg and extends from the distal tip.

A bone joint implant (1) has a proximal part (120) for translational motion over the trapezium in a first carpometacarpal joint and a distal part (110) for intramedullary engagement in the first metacarpal bone. An articulating coupling (103, 121, 123) is for multi-axial motion with translational movement over a bone in one part (120) and rotation in the other part (110) about the articulating coupling (121, 103). A flange (105) extends radially and around the coupling to limit relative rotational motion of the proximal and distal parts about the coupling, and to provide resilience for contact between the proximal and distal parts. The flange has a contoured surface (101) matching an abutting surface (125) of the proximal part (122) upon articulation of the parts in use to extreme positions. The flange (105) is included in an insert (100) in a stem (111) of the distal part (110), the flange extending proximally of the stem (111) and prohibiting contact between the proximal part (120) and the stem (111) during articulation.

An intervertebral implant includes a body with a first face, a second face connected to the first face, and an axis of rotation. The body defines a hollow space for connecting to an insertion device, the hollow space being accessible through an opening formed between the first and second faces. The opening is elongate and extends around the axis of rotation to facilitate pivoting of the implant relative to the insertion device about the axis of rotation to a first angular position and a second angular position. The implant further includes a first abutment surface that engages the insertion device in a form-fit manner at the first angular position, and a second abutment surface that engages the insertion device in a form-fit manner at the second angular position. The opening can also engage the insertion device to hold the implant at at least one additional angular position.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.