The present invention provides an active substance application insert (10, 110) for an implant (30), in particular a joint implant. The active substance application insert has a main body (11), an active substance chamber (12) formed in the main body, an application side (13, 113) which forms a front face of the active substance chamber, wherein the application side has a plurality of application openings (14, 114), and a securing means (15) with which the main body can be detachably secured in the implant. In a state in which the main body is inserted into the implant, the application side faces outwards relative to the implant, such that the application openings connect the active substance chamber to the environment of the implant. Furthermore, within the scope of the present invention an implant (30) with a recess (31) for receiving an active substance application insert (10, 110) is provided.

A method of creating a drug eluting system for hernia repair in a patient is provided. The includes providing an implantable mesh for hernia repair comprised of at least one of polytetrafluoroethylene fibers or polytetrafluoroethylene filaments, wherein the at least one of the polytetrafluoroethylene fibers or polytetrafluoroethylene filaments is at least one of directionally or non-directionally oriented, positioning a pharmaceutical agent on the implantable mesh, and coating at least a portion of the at least one of the polytetrafluoroethylene fibers or polytetrafluoroethylene filaments and the pharmaceutical agent with a polymer, wherein the implantable mesh is configured to be positioned in the body of the patient during the repair of the hernia and the pharmaceutical agent elutes from the implantable mesh into the body of the patient at the site of the hernia repair.

An interbody fusion device having an accordion-like structure, wherein the device in inserted into the disc space in its collapsed configuration and then expanded into its expanded configuration by compressing the accordion-like portion of the device. In some embodiments, a pre-formed tube with an accordion-like structure over a portion of its length is inserted in a relaxed (collapsed) configuration, giving the tube a minimum possible diameter. This tube has a cable running through it that is fixed to a distal end portion of the tube and extends past the proximal end portion of the tube to the outside of the patient. Once the tube is positioned on the rim of the endplate, the proximal end of the cable is pulled, thereby tensioning the cable and causing the accordion portion of the tube to become shorter in length but larger in diameter.

The present invention provides a method for stabilizing a fractured bone. The method includes positioning an elongate rod in the medullary canal of the fractured bone and forming a passageway through the cortex of the bone. The passageway extends from the exterior surface of the bone to the medullary canal of the bone. The method also includes creating a bonding region on the elongate rod. The bonding region is generally aligned with the passageway of the cortex. Furthermore, the method includes positioning a fastener in the passageway of the cortex and on the bonding region of the elongate rod and thermally bonding the fastener to the bonding region of the elongate rod while the fastener is positioned in the passageway of the cortex.

A reduced pressure delivery system for applying reduced pressure tissue treatment to a tissue site is provided. The system includes a manifold delivery tube and a balloon having an inner space. The balloon is capable of assuming collapsed and expanded positions. The system further includes a manifold having a plurality of flow channels. The manifold is disposed within the inner space of the balloon. A sharp tip is configured to be delivered within the manifold delivery tube to puncture the balloon.

Various embodiments provide systems and methods for repairing or replacing intervertebral discs as a treatment for derangements. Systems and methods may comprise an intervertebral disc implant for deployment into an intervertebral disc space wherein the nucleus has been at least partially evacuated from the deranged intervertebral disc. The intervertebral disc implant may be intraoperatively and postoperatively filled and/or re-filled with a growth matrix. The intervertebral disc implant may be differentially permeable to the growth matrix to provide directional growth and/or diffusion of the growth matrix to restore height to the intervertebral disc space. Systems and methods may further comprise an implant delivery device for deploying the intervertebral disc implant into the intervertebral disc space.

An orthopedic system for delivery of a therapeutic agent to a bone includes an elongate stem adapted to be inserted into an intramedullary canal, an inlet configured to receive the therapeutic agent, and one or more outlets configured to deliver the therapeutic agent to the bone. The elongate stem may comprise one or more protrusions to engage the bone, and one or more channels extending longitudinally therein, fluidly coupled to the inlet. The therapeutic agent flows from the inlet through the one or more channels and exits into the intramedullary canal through the one or more outlets. The system may be configured to allow one or more dimensions of the system to be adjusted to accommodate the anatomy of a patient.

Disclosed herein is a temporary knee spacer system for the temporary replacement of a knee joint, which is designed for the interim phase of two-stage septic revisions of knee joint total endoprostheses. The knee spacer system can be used in particular with two-phase septic revisions with which two or more microbial germs are the cause of an infection of the knee joint total endoprosthesis and the surrounding tissue.

Bone graft scaffold arrangements are described that can be used in minimally invasive posterolateral spinal fusion. The bone graft scaffold apparatus comprise a housing which comprises a cavity for receiving bone growth promoting materials and a plurality of apertures. In use these allow bone and blood vessels to grow through the plurality of apertures to form the bone bridge between vertebrae. Further the bone graft scaffold apparatus comprise at least one opening in the housing for receiving a shaft of an orthopaedic device, such as rod linking pedicle screws, or the shaft of a pedicle screw, or another suitable shaft in another surgical procedure. The apparatus can be attached to structural components such as rods and screws and used to form a continuous scaffold between vertebras to assist in forming a bone bridge.

A reduced pressure delivery system for applying reduced pressure tissue treatment to a tissue site is provided. The system includes a manifold delivery tube and a balloon having an inner space. The balloon is capable of assuming collapsed and expanded positions. The system further includes a manifold having a plurality of flow channels. The manifold is disposed within the inner space of the balloon. A sharp tip is configured to be delivered within the manifold delivery tube to puncture the balloon.