Provided herein are devices and methods for treating inflammation and pain of articular joints (e.g., the knee). An implantable device includes an elongate body extending from a proximal end to a distal end, a flange disposed at the proximal end, a bore extending from an opening at the proximal end into the elongate body, one or more fixation members disposed on an outer surface of the elongate body, and a payload (e.g., a drug-polymer core) having a therapeutic agent disposed within the bore. The payload has a substantially constant surface area on an exposed portion throughout elution of the therapeutic agent after the implantable device is implanted in a body. The therapeutic agent is configured to elute using zero-order kinetics, constantly and continuously at an amount that is above a predetermined lower threshold and does not exceed a predetermined upper threshold unlike a pulse-dose injection.

A spinal fixation device includes an outer housing and an end plate assembly coupled with the outer housing. The outer housing defines an aperture and a longitudinal axis. At least a portion of the end plate assembly is slidably received within the outer housing. The end plate assembly includes a first end plate configured to engage a vertebral body, wherein the end plate assembly is selectively movable between a first position in which the first end plate is spaced apart from the outer housing and a second position in which the first end plate is adjacent the outer housing. Further, the first end plate is selectively adjustable to an angular orientation of a plurality of angular orientations with respect to the longitudinal axis of the outer housing.

An orthopedic implant includes an internal fixation device. The internal fixation device includes: an exterior surface; a threaded section including a reservoir and at least one threaded section channel fluidly communicating the reservoir with the exterior surface, each threaded section channel having an interior diameter and a length which is greater than the interior diameter; a head including a head channel fluidly communicating the reservoir with an exterior surface of the head, a channel diameter of the head channel being respectively larger than a largest interior diameter of each threaded section channel, the channel diameter of the head channel being the same as a large interior diameter of the reservoir; and a continuously tapering inner surface between the head channel and the reservoir.

An orthopedic implant includes an internal fixation device. The internal fixation device includes: an exterior surface; a threaded section including a reservoir and at least one threaded section channel fluidly communicating the reservoir with the exterior surface, each threaded section channel having an interior diameter and a length which is greater than the interior diameter; a head including a head channel fluidly communicating the reservoir with an exterior surface of the head, a channel diameter of the head channel being respectively larger than a largest interior diameter of each threaded section channel, the channel diameter of the head channel being the same as a large interior diameter of the reservoir; and a continuously tapering inner surface between the head channel and the reservoir.

Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.

A method includes forming a mixture including a therapeutic agent and a solid delivery medium, injecting the mixture into a reservoir within an orthopedic implant body, and storing the injected mixture in the reservoir.

An orthopedic implant device includes an implant body with a reservoir configured store a therapeutic agent. A wall of the implant body has opposite side surfaces, including a side surface facing into the reservoir. Elution channels reach from the reservoir through the body wall. The elution channels include an elongated channel traversing a thickness of the body wall between the opposite side surfaces. The elongated channel may have a length greater than twice the thickness.

An implantable modular spacer device to treat an infected articular seat includes a stem element, a head or ball element, and coupling elements between the stem element and the head that include a plurality of elongated teeth, placed at pre-established distances from each other, and a plurality of housing seats for the teeth. An implantable spacer device to treat a bone seat or joint seat or for the two-step treatment of infections of joint prostheses includes a joint component adapted to be inserted in an articular zone of the patient and having an external surface, a stem component adapted to be implanted in a bone or in a residual bone bed of a preceding joint prosthesis, and adjustable connection elements, wherein at least part of the external surface of the first portion of the stem component and at least part of the external surface of the joint component define a contact surface with the bone tissue or adapted for coupling with the bone tissue. The connection elements are placed between the joint component and the stem component to adjust the distance thereof, and the contact surface in the joint component and/or in the stem component has a plurality of recesses or housing a filling material that includes a pharmaceutical or medical substance, wherein the plurality of recesses affects or is substantially placed along the entire contact surface or in proximity thereto.

Prosthetic device suitable for being implanted in a bone or joint site of the human body, including a prosthetic body, wherein the prosthetic device includes or can be added with antibiotic or a medical substance.

The present invention provides a method for stabilizing a fractured bone. The method includes positioning an elongate rod in the medullary canal of the fractured bone and forming a passageway through the cortex of the bone. The passageway extends from the exterior surface of the bone to the medullary canal of the bone. The method also includes creating a bonding region on the elongate rod. The bonding region is generally aligned with the passageway of the cortex. Furthermore, the method includes positioning a fastener in the passageway of the cortex and on the bonding region of the elongate rod and thermally bonding the fastener to the bonding region of the elongate rod while the fastener is positioned in the passageway of the cortex.