A61K31/546

METHODS FOR TREATING PULMONARY NON-TUBERCULOUS MYCOBACTERIAL INFECTIONS
20230037417 · 2023-02-09 ·

Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and/or NTM culture conversion to negative during or after the administration period.

COMPOSITIONS AND METHODS OF POTENTIATING ANTIMICROBIALS

Disclosed herein are pharmaceutical compositions comprising at least one anti-bacterial and at least one cannabinoid and methods of use in treating or preventing bacterial infection or biofilm in a subject in need thereof.

COMPOSITIONS AND METHODS OF POTENTIATING ANTIMICROBIALS

Disclosed herein are pharmaceutical compositions comprising at least one anti-bacterial and at least one cannabinoid and methods of use in treating or preventing bacterial infection or biofilm in a subject in need thereof.

COMPOSITIONS AND METHODS OF POTENTIATING ANTIMICROBIALS

Disclosed herein are pharmaceutical compositions comprising at least one anti-bacterial and at least one cannabinoid and methods of use in treating or preventing bacterial infection or biofilm in a subject in need thereof.

Compositions and methods of potentiating antimicrobials

Disclosed herein are pharmaceutical compositions comprising at least one anti-bacterial and at least one cannabinoid and methods of use in treating or preventing bacterial infection or biofilm in a subject in need thereof.

Compositions and methods of potentiating antimicrobials

Disclosed herein are pharmaceutical compositions comprising at least one anti-bacterial and at least one cannabinoid and methods of use in treating or preventing bacterial infection or biofilm in a subject in need thereof.

Compositions and methods of potentiating antimicrobials

Disclosed herein are pharmaceutical compositions comprising at least one anti-bacterial and at least one cannabinoid and methods of use in treating or preventing bacterial infection or biofilm in a subject in need thereof.

METHODS TO CONTROL INFECTION USING NEW GENERATION SMALL MOLECULE GROWTH INHIBITORS

Disclosed herein are methods of treating a subject with a bacterial infection preventing a bacterial infection, comprising administering to the subject an effective amount of at least one compound, of a derivative thereof, having the formula of SM1, SM3, SM4 or SM5. Also described are methods of inhibiting bacterial growth in a plant comprising contacting the plant with an effective amount of at least one compound, or a derivative thereof, testing the formula of SM1, SM3, SM4, or SM5. The methods are effective against the area of bacterial pathogens in various animals and plants.

METHODS TO CONTROL INFECTION USING NEW GENERATION SMALL MOLECULE GROWTH INHIBITORS

Disclosed herein are methods of treating a subject with a bacterial infection preventing a bacterial infection, comprising administering to the subject an effective amount of at least one compound, of a derivative thereof, having the formula of SM1, SM3, SM4 or SM5. Also described are methods of inhibiting bacterial growth in a plant comprising contacting the plant with an effective amount of at least one compound, or a derivative thereof, testing the formula of SM1, SM3, SM4, or SM5. The methods are effective against the area of bacterial pathogens in various animals and plants.

METHODS TO CONTROL INFECTION USING NEW GENERATION SMALL MOLECULE GROWTH INHIBITORS

Disclosed herein are methods of treating a subject with a bacterial infection preventing a bacterial infection, comprising administering to the subject an effective amount of at least one compound, of a derivative thereof, having the formula of SM1, SM3, SM4 or SM5. Also described are methods of inhibiting bacterial growth in a plant comprising contacting the plant with an effective amount of at least one compound, or a derivative thereof, testing the formula of SM1, SM3, SM4, or SM5. The methods are effective against the area of bacterial pathogens in various animals and plants.