Disclosed herein are photoactivable fluorophores comprising one or more thiocarbonyl groups as well as conjugates and compositions thereof. The present disclosure also provides methods of preparing photoactivatable fluorophores as well as methods of imaging using the photoactivatable fluorophores, conjugates, and compositions of the present disclosure.

The present invention relates to a complex comprising at least one dendrimer and at least one lanthanide, wherein the dendrimer comprises a unit of formula (I) below:

##STR00001##

in which: C.sub.1 is a valence group 4 of formula >NCH.sub.2CH.sub.2N<; A.sub.1, A.sub.2 and A.sub.3 are groups of formula (CH.sub.2).sub.2C(O)NH(CH.sub.2).sub.2; the unit of formula (I) being connected covalently to at least one antenna which absorbs at a wavelength ranging from 500 nm to 900 nm.

The present invention is in the field of surfactants to extract a platinum group metal or gold, in particular palladium, from organic compositions. In particular, the invention concerns the use of surfactants to back-extract a platinum group metal or gold, in particular palladium, from organic compositions further comprising an extractant of said platinum group metal or gold, in particular palladium from an aqueous solution.

The invention is directed to a staining composition and to the use of the staining composition in staining ocular tissue. In a first aspect, the invention provides a staining composition comprising a vital dye and a density increasing compound chosen from the group consisting of water soluble polymers and small inert molecules.

Disclosed herein are high Tm RNA nanostructures that can be composed of one or more modules or motifs to build RNA nanostructures with or without layers. The RNA nanostructures can have a core domain and three or more double-stranded arms and formulations thereof to conjugate high copy numbers of therapeutics, pH responsive or enzyme cleavable drug cargo. Also described herein is a design strategy for generation of synthetic RNA oligonucleotides that can self assemble into highly thermostable RNA structures. Also described herein are uses of the RNA nanostructures described herein.

The present invention provides methods and compositions based on optical sensor conjugates that are useful for detecting reactive oxygen, reactive nitrogen, or both species that are a direct result of inflammation caused by tissue damage.

The present invention relates to novel amphiphilic dendrimers, hereafter denoted Dendri-TAC. The present invention also relates to perfluorocarbon nanoemulsions stabilized by these amphiphilic dendrimers and their uses for in vivo diagnostic and/or for therapy, notably as theranostic tools, for detection and/or treatment of cancer.

The present invention relates to an antibody-fluorescent dye conjugate capable of cancer cell-specific fluorescence imaging diagnosis, wherein the fluorescent dye comprises a covalently labeled antibody and is structured to be quenched by interaction with an amino acid residues in the antibody, selected from the group consisting of tryptophan, tyrosine, histidine, and methionine, and to be dequenched upon binding of the antibody to an antigen present on a cell surface to emit fluorescence, whereby cells having a target antigen thereon can be imaged for diagnosis. When using the antibody-fluorescent dye conjugate according to the present invention, in vitro cell assays, high-throughput screening of cells, and cytodiagnosis based on microfluidics exhibit the effect of detecting the presence of cancer cells having a specific antigen expressed thereon at high specificity and sensitivity without a washing process, and can detect the position of primary and metastatic cancer cells at high contrast within a short time, thereby enhancing the accuracy of fluorescent image-guided surgeries and a therapeutic effect.

The present invention relates to a nanocomposite for detecting hydrogen sulfide; a method for preparing the same; a novel reactive fluorogenic compound to be used in the method; a kit for detecting hydrogen sulfide comprising the nanocomposite; and a method for providing information for the diagnosis of a disease, which causes abnormal secretion of hydrogen sulfide, by using the nanocomposite.

The present invention provides an epidermal penetration type ink composition comprising: a fluorescent colorant containing at least one selected from the group consisting of indocyanine green (ICG), cyanine, phthalocyanine, oxazine, rhodamine, and a mixture thereof; a binder resin containing at least one of polyvinylpyrrolidone (PVP) and polyvinylbutyral (PVB); and a solvent containing at least one of ethanol and isopropanol.