Pressure measurement system (e.g., for an extracorporeal treatment system), method and pressure pod apparatus including a position sensor for use in repositioning a diaphragm that separates a liquid side cavity from a transducer side cavity (e.g., operatively connected to a pressure transducer); the liquid side cavity being in fluid communication with an inlet and an outlet.

A disposable cartridge for use in a hemodialysis machine has a blood flow path for carrying a volume of blood to be treated in a dialyser and a dialysate flow path, isolated from the blood flow path, for delivering a flow of dialysate solution through the dialyser. The cartridge is received in an engine section of the machine. The engine section has first and second platens which close when the cartridge is inserted to retain the cartridge. Actuators and sensors arranged on the second platen control operation of the cartridge.

The present invention relates to a blood treatment machine having a control, having a pump actuator for pumping blood through an extracorporeal blood circuit which comprises an arterial line and a venous line, and having a pressure sensor for detecting the pressure in the venous line, wherein the control has a detection function for detecting a venous needle disconnect which compares a value determined on the basis of the pressure in the venous line with a limit value to recognize a venous needle disconnect, wherein the limit value with which the detection function compares the value determined on the basis of the pressure in the venous line can be set variably and/or is set variably by the control.

Blood in a separation chamber is separated into a red blood cell layer, a plasma constituent, and a mononuclear cell-containing layer. A portion of the plasma constituent exits the chamber via a plasma outlet, while a first portion of the red blood cell layer exits via a red blood cell outlet. A second portion of the red blood cell layer exits the chamber via the red blood cell outlet and is collected. At least a portion of the collected red blood cell layer may then be conveyed to the chamber via the red blood cell outlet to convey at least a portion of the mononuclear cell-containing layer out of the chamber via the plasma outlet for collection. A second portion of the plasma constituent may be conveyed out of the chamber via the plasma outlet to more fully collect the mononuclear cell-containing layer without the use of collected plasma.

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that to can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

A blood component sampling cassette which can be more efficiently manufactured at lower cost as compared to a typical cassette, a blood sampling circuit set, and a blood component sampling system. A blood component sampling cassette (22) includes a cassette main body (23) made of a soft material to which heat sterilization is applicable. The cassette main body (23) is provided with a retransfusion line (44). The retransfusion line (44) is provided with a reservoir (47) configured to temporarily store a blood component to be returned to a blood donor. The reservoir (47) is pressed by a retransfusion pump (49) to discharge the blood component from the reservoir (47).

A flow path is formed in a cassette body of a blood component collection cassette. The cassette body includes a bulging structure in which at least a portion of the flow path is formed. A first gripped member, which is configured to be gripped by a first gripping member provided on a centrifugal separation device, is disposed on one surface of the bulging structure in a thickness direction thereof. A second gripped member, which is configured to be gripped by a second gripping member to which a load detection unit that is provided on the centrifugal separation device is fixed, is disposed on another surface of the bulging structure in the thickness direction thereof.

Blood in a separation chamber is separated into a red blood cell layer, a plasma constituent, and a mononuclear cell-containing layer. A portion of the plasma constituent exits the chamber via a plasma outlet, while a first portion of the red blood cell layer exits via a red blood cell outlet. A second portion of the red blood cell layer exits the chamber via the red blood cell outlet and is collected. At least a portion of the collected red blood cell layer may then be conveyed to the chamber via the red blood cell outlet to convey at least a portion of the mononuclear cell-containing layer out of the chamber via the plasma outlet for collection. A second portion of the plasma constituent may be conveyed out of the chamber via the plasma outlet to more fully collect the mononuclear cell-containing layer without the use of collected plasma.

An apparatus for treating a hemorrhaging wound and returning blood to the body includes at least one vacuum hose; tubing to return blood to the body; a reservoir to temporarily contain the blood, an ejectable filter between the vacuum hose and the reservoir, a temperature regulator to regulate the temperature in the reservoir; at least one pressure regulator connected to the at least one vacuum hose; a vacuum pump connected to the at least one pressure regulator, and an infusion pump connected to the tubing to return blood to the body. Blood is returned to the body via multi access catheter and/or consistent with present and future rapid infusion procedural methods that could change according to severity of injuries and the need for alternate vascular access points and/or infusion delivery protocols.