Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

A blood component collection system, which is one form of a biological component collection system, is equipped with a centrifugal separation device and a biological component collection device. The biological component collection device comprises a pressed soft portion pressed by a load detecting unit. The centrifugal separation device includes a collection and returning pump, and a control unit having an internal pressure computation unit which calculates a circuit internal pressure of the biological component collection device on the basis of a detection value of the load detecting unit. The internal pressure computation unit performs a zero reset process of setting a pressure value corresponding to the detection value of the load detecting unit, so as to become zero at each instance of a predetermined timing at which the collection and returning pump is stopped.

Blood in a separation chamber is separated into a red blood cell layer, a plasma constituent, and a mononuclear cell-containing layer. A portion of the plasma constituent exits the chamber via a plasma outlet, while a first portion of the red blood cell layer exits via a red blood cell outlet. A second portion of the red blood cell layer exits the chamber via the red blood cell outlet and is collected. At least a portion of the collected red blood cell layer may then be conveyed to the chamber via the red blood cell outlet to convey at least a portion of the mononuclear cell-containing layer out of the chamber via the plasma outlet for collection. A second portion of the plasma constituent may be conveyed out of the chamber via the plasma outlet to more fully collect the mononuclear cell-containing layer without the use of collected plasma.

A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.

A controller for a blood processing device has a body that may dock and undock with a first blood processing device to connect the controller to the first blood processing device and disconnect the controller from the first blood processing device. A processor within the controller controls the first blood processing device when the controller is docked with the first blood processing device and remotely controls the first blood processing device when undocked. The controller also has a user interface that displays information regarding the first blood processing device and an ongoing apheresis procedure when the controller is docked to the first blood processing device and when the controller is undocked from the first blood processing device.

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.

An external functional means comprises at least one housing body, at least one chamber integrated into the housing body for receiving medical fluids, at least one passage integrated into the housing body for receiving and/or conducting a medical fluid, and at least one valve means completely or partly integrated into the housing body for controlling or regulating a fluid flowing through the external functional means. The invention further specifies a blood treatment apparatus and methods which may be carried out by means of the external functional means of the invention and by means of the blood treatment apparatus, respectively.

The present invention relates to a method for removing a first fluid from a blood filter for the blood treatment of a patient and/or for removing blood from the blood filter after completing the blood treatment session. It further relates to a medical treatment apparatus having a control device with which a method for removing a first fluid from a blood filter is executable, a digital storage medium, and a computer program product.

A blood component collection system, which is one form of a biological component collection system, is equipped with a centrifugal separation device and a biological component collection device. The biological component collection device comprises a pressed soft portion pressed by a load detecting unit. The centrifugal separation device includes a collection and returning pump, and a control unit having an internal pressure computation unit which calculates a circuit internal pressure of the biological component collection device on the basis of a detection value of the load detecting unit. The internal pressure computation unit performs a zero reset process of setting a pressure value corresponding to the detection value of the load detecting unit, so as to become zero at each instance of a predetermined timing at which the collection and returning pump is stopped.