A first blood processing member 5U and a second blood processing member 5D are arranged in a first housing 2/U and a second housing 2/D, respectively. The first blood processing member 5U and the second blood processing member 5D are arranged in such a manner that inside filtration sections 5FI/U and 5FI/D face each other. A first blood chamber 2.1 is formed between the inside filtration sections 5FI/U and 5FI/D, and a second blood chamber 2.2 is formed between the inner periphery of the first housing 2/U and an outside filtration section 5FO/U and between the inner periphery of the second housing 2/D and an outside filtration section 5FO/D. A blood inlet port 7I communicates with the first blood chamber 2.1 (a blood inflow chamber 2IR), and a blood discharge port 7O communicates with the second blood chamber 2.2 (a blood outflow chambers 20R/U and 20R/D).

Medical fluid management assembly includes: a pneumatic manifold including multiple plates forming pneumatic passageways, a pneumatic valve chamber and a pneumatic pump chamber, the valve chamber in pneumatic communication with at least one passageway, the pump chamber in pneumatic communication with at least one passageway; and a fluid manifold including multiple fluid pathways, a fluid valve chamber in selective fluid communication with a fluid pump chamber and at least one fluid pathway, wherein (a) the pneumatic valve chamber and the fluid valve chamber are mated together to compress a membrane and (b) the pneumatic pump chamber and the fluid pump chamber are mated together to compress a membrane, wherein at least one of the pneumatic valve chamber or the pneumatic pump chamber extends from the at least one plate, or the fluid valve chamber or the fluid pump chamber extends from the fluid manifold to aid in compressing the membranes.

A blood processing filter for removing undesirable components from liquid containing a blood component or blood, comprises: a sheet-shaped filter element; and a container that includes an inlet-side container element and an outlet-side container element that are disposed to clamp the filter element, and has an internal space separated by the filter element into an inlet space and an outlet space, wherein the filter element includes a filtering surface on a side of the inlet space, a filtering surface on a side of the outlet space, and an end surface along peripheries of the pair of filtering surfaces, and the inlet-side container element and the outlet-side container element are provided with a gripper, and the gripper clamps and compresses an outer edge portion of the pair of filtering surfaces, and is caused to adhere to the end surface with melt resin.

A blood processing filter comprises an inlet-side flexible container and an outlet-side flexible container that sandwich a filter element, an inlet port, and an outlet port, the filter further comprising: a flow path securing sheet; a first seal portion; and a second seal portion, wherein the flow path securing sheet includes a pair of ribs disposed opposite to each other with the outlet port interposed therebetween, and a slit formed inside of the pair of ribs, and diffusing openings that are disposed outside of the pair of ribs and continuously open from the ribs to the lateral portions of the first seal portion.

Filter assemblies are processing biological fluid, such as blood or a blood component containing leukocytes. The filter assemblies include a flexible housing with first and second walls. A filtration medium and a support member are at least partially positioned between the walls of the housing, with a seal joining the walls of the housing, the filtration medium, and the support member. The filter assemblies may further include a pre-filter and/or a post-filter positioned between the walls of the housing. If provided, the pre- and post-filter may be positioned on opposite walls of the filtration medium, with the post-filter being a mesh positioned between the filtration medium and one of the walls of the housing or within an opening defined by the support member. A seal of the filter assembly may pass through the filtration medium, with the filtration medium being substantially omitted in a section of the seal.

Flexible housing filters for filtration of fluids and methods of making such filters are disclosed. The filters may include one or more peripheral seals in the flexible housing.

The invention relates to a filtration unit for enabling the selective leucocytapheresis of a fluid containing blood platelets. The filtration unit includes an external pouch provided with an inlet orifice and an outlet orifice, the pouch enclosing a porous element interposed between the orifices. The porous element encloses a leucocytapheresis medium impregnated with a polymer, the polymer having the general formula -(A)m-(B)n- (I), wherein A is a unit originating from an alkoxyalkyl acrylate or alkoxyalkyl methacrylate monomer, B is a unit originating from a hydrophobic polymerisable monomer, and m and n are integers, the sum of which, m+n, is equal to 100, m being an integer greater than 80.

A blood processing filter for removing undesirable components from liquid containing a blood component or blood, comprises: a sheet-shaped filter element; and a hard container that includes an inlet-side container element and an outlet-side container element that are disposed to clamp the filter element, and has an internal space separated by the filter element into an inlet space and an outlet space, wherein the filter element includes a filtering surface on a side of the inlet space, a filtering surface on a side of the outlet space, and an end surface along peripheries of the pair of filtering surfaces, the inlet-side container element and the outlet-side container element are provided with a gripper that clamps and compresses an outer edge portion of the pair of filtering surfaces, and a thickness of the filter element is compressed at the gripper to be 0.05 to 0.5 times the thickness.

A method of recovering white blood cells from a leukoreduction filter, the method comprising providing a solution comprising a sugar, flowing a volume of the solution through a leukoreduction filter containing captured white blood cells, and collecting elute from the leukoreduction filter, wherein the elute comprises the solution and recovered white blood cells.

Flexible housing filters for filtration of fluids and methods of making such filters are disclosed. The filters include a molded frame with no peripheral seal that houses a filter medium.