The present disclosure relates to an injection device for setting and dispensing of a dose of a medicament, the device including an elongated housing to accommodate a cartridge filled with the medicament and sealed with a piston, a piston rod extending along a first axis and being threadedly or slidingly engaged with the housing to apply a distally directed thrust to the piston of the cartridge, a drive member rotationally or threadedly engaged with the piston rod and having a wheel section or geared section, and a drive sleeve extending along a second axis at a radial distance from the first axis and having a geared section to mesh with the wheel section or geared section of the drive member, wherein a first radial distance between first and second axes at a distal end of the drive sleeve differs from a second radial distance between first and second axes at a proximal end of the drive sleeve.

The invention relates to a medicament delivery device comprising a locking mechanism (5) for locking a plunger rod (4). The locking mechanism (5) comprises a locking wheel (6) and locking means (7), said locking means (7) being moveable between an active position where the locking means (7) prevent the locking wheel (6) from rotation and an inactive position where the locking means (7) allow the locking wheel (6) to rotate, wherein said plunger rod (4) extends through an opening in the locking wheel (6); and a resilient member (8) arranged at the moveable locking means (7) and being arranged to act on the moveable locking means (7) to displace said movable looking means (7) towards the inactive position where the locking means (7) allow the locking wheel (6) to rotate.

Disclosed is a syringe for a micro-dosing syringe pump. The syringe includes a reservoir having an outlet port; a plunger having a track, with the plunger received inside a portion of the reservoir; a plunger driver comprising a gear connected to one end of a shaft and a pin located adjacent an opposite end of the shaft, with the plunger driver received inside the plunger and with the pin located inside and engaging the track. In use, rotation of the gear in a first direction advances the plunger into the reservoir a first distance as the pin travels in the track and rotation of the gear in a second direction opposite the first direction advances the plunger a further distance into the reservoir as the pin travels in the track. The design prevents excess dosing in a runaway motor failure.

A drug delivery device comprises a medicament reservoir attached to a housing, a drive mechanism comprising a plunger movable relative to the housing, a dose selecting element releasably coupled to the drive mechanism and rotatable relative to the housing, a trigger axially movable relative to the housing, and a limiter selectively permitting and preventing axial movement of the trigger depending on the amount of a selected dose. The limiter is constrained to the dose selecting element and to the trigger. One of the limiter or a component part is axially coupled to the housing comprises a track which is in engagement with a blocking feature of the other of the limiter or the component part axially coupled to the housing. The track comprises a narrow section limiting relative movement between the track and the blocking feature and a wide section permitting relative movement between the track and the blocking feature.

A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.

An assembly for a drug delivery device comprises a housing, a dose member which is displaceable in a proximal direction with respect to the housing for setting of a dose of a drug, a clutch member which is displaced in the proximal direction with respect to the housing when setting the dose, and a stop member configured to define a clutch stop position. The clutch member and the dose member are configured to mechanically cooperate with one another when the clutch member is in the clutch stop position, thereby preventing further displacement of the dose member in the proximal direction with respect to the housing during setting of the dose.

A controlled multidosing delivery device for use with a syringe includes a housing, a plunger rod and a drive shell. The housing having an axially extending chamber including openings at either end, the distal end being adapted for attachment to the syringe barrel. The plunger rod includes a contact button at the proximal end of an elongated shaft and a pusher feature at the distal end. The drive shell is disposed for axial translation within the axially extending chamber. The drive shell includes a head disposed for translation along the axis to provide dose delivery, a plurality of engagement surfaces for engagement by the pushing feature, and a retention feature that inhibits proximal movement of the drive shell when engaged. Depression of the contact button axially translates the elongated shaft and pusher feature in engagement with the at least one of the engagement surfaces to translate the drive shell in the distal direction, whereby the retention feature engages to maintain axial position of the drive shell in the housing following dose delivery, and a biasing structure translates the plunger rod in the proximal direction following translation of the drive shell.

Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

An injection device comprises a dose selector, rotatable by a user to set a dose to be ejected from the injection device and a drive assembly including a drive shaft (140) and a plunger element (145), the drive assembly being capable of providing an axial force for ejecting a dose of medicament from a medicament container. A dose limit nut (141) is provided which is rotationally coupled to but not axially coupled to said drive shaft. The plunger element is threaded so that the dose limit nut is engaged with said plunger element via said thread, in order to guide relative axial movement between the dose limit nut and the plunger element. The dose limit nut is provided with dose limiting endstops which are capable of limiting axial travel of said dose limit nut with respect to said plunger element, so as to limit maximum and minimum doses of medicament which can be set by the user. In addition, the dose limit nut comprises a last dose rotary endstop feature which prevents further rotation of said dose limit nut with respect to said drive shaft so as to prevent the user setting a dose that is greater than an injectable volume of medicament remaining in said medicament container.

Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.