The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament and to a housing for such a device. The housing comprises an outer housing with a distal end and a cartridge holder with a proximal end, which, when the cartridge holder is attached to the outer housing, is inserted into the distal end of the outer housing. The outer housing is provided with a first fixture for axially constraining a further component part to the outer housing. When the cartridge holder is attached to the outer housing, the proximal end of the cartridge holder axially extends to the first fixture.

The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing, a dose selector operable to set a dose by rotation relative to the housing, a number sleeve arranged within the housing, a drive sleeve which is rotationally constrained to the housing during dose setting and dose correcting and which is rotatable relative to the housing during dose dispensing, a piston rod coupled to the housing and to the drive sleeve a drive spring arranged between the housing and the number sleeve, and a ratchet operatively arranged between the drive sleeve and the number sleeve. According to the disclosure the ratchet comprises at least one clicker arm of one of the number sleeve and the drive sleeve and ratchet teeth of the other of the number sleeve and the drive sleeve.

A method for assembling a drive spring, especially into a drug delivery device includes rotating a component part to which the drive spring is attached in a first direction, followed by a rotation of the component part in the opposite direction and followed by attachment of a rotational stop. Further, the disclosure includes a drug delivery device for selecting and dispensing a number of user variable doses of a medicament, which device comprises a pre-charged drive spring.

A dose setting mechanism for a drug delivery device is provided comprising a dose setting member and a further element. Maximum dose stop features are provided on a housing and on the further element.

An assembly for a drug delivery device is provided comprising a screw member comprising a thread, the thread including at least two consecutive portions, the portions having different leads. The device further includes a nut member. The assembly is configured such that, in a first portion of the thread, the nut member includes a first position with respect to an axis transversal to the rotational axis and in a second portion of the thread, the nut member includes a second position with respect to the axis transversal to the rotational axis. The nut member is configured to perform a tilting movement from the first position into the second position when the nut member passes from the first portion to the second portion. Furthermore, a drug delivery device comprising the assembly is described.

Medical device (1) for injecting a set dose of an injectable product into a patient, the device having a cartridge containing the injectable product, a movable dosing driver (11) and a movable dose setting driver (15), and an end-of-contents indicator system (13) having counting means (17) with a counting part (19), and indication means (21) with a signal part (23), wherein the counting part (19) and the signal part (23) are formed with cooperating end-of-contents contact faces (25′, 25″), wherein the signal part (23) is movable between a first indication position and a second indication position, wherein the signal part (23) comprises a biasing means (33) for biasing the signal part (23) towards the first indication position, wherein the counting part (19) comprises a coupling (26), said coupling (26) is configured for operably connecting the counting part (19) to the dose setting driver (15), such that moving of the dose setting driver(15) towards increasing the set dose moves the contact face (25′) of the counting part (19) in relation to the contact face (25″) of the signal part (23) towards engagement of the contact surfaces (25′, 25″), and such that moving of the dose setting driver (15) towards decreasing the set dose moves the contact face (25′) of the counting part (19) away from the contact face (25″) of the signal part (23), wherein the counting part (19) is configured for providing engagement of the contact faces (25′, 25″) when the set dose reach the end-of-contents in the cartridge, and wherein the counting part (19) is configured for moving the signal part (23) towards the second indication position when the set dose is exceeding the end-of-contents in the cartridge. This way, if the user tries to dial a dose of drug beyond the amount remaining in the cartridge, an additional indication is given to the user via a distinctive area (41/43) of the signal part (23) becoming visible through a window (7) of the injector.

An injection device for dispensing a dose of a product by manually advancing a piston rod includes a dosing and dispensing mechanism having a housing with a longitudinal axis, a dosing sleeve mounted in the housing for adjusting and correcting the dose, a housing insert fixed to the housing and arranged inside the dosing sleeve, and a coupling sleeve mounted in the housing for driving the piston rod. For setting and correcting a dose, the dosing sleeve is rotatable relative to the coupling sleeve, and for dispensing the dose, the dosing sleeve can be coupled to the coupling sleeve in a rotationally fixed manner. In this case, the coupling sleeve has a locking element which can interact with the housing insert so that the coupling sleeve can be rotated in a first direction of rotation and cannot be rotated in a second direction of rotation relative to the housing insert.

A mechanism for preventing setting of a dose, which exceeds the amount of a medicament in a reservoir in an injection device. The device can contain a threaded piston rod, a limiter and a driver. The three elements can be arranged such that during dose setting, the limiter is moved towards an end-of-content position, wherein dose setting is limited. The invention contains an accumulative and a non-accumulative embodiment. The invention further relates to a mechanism for preventing ejection of a dose exceeding the set dose.

Drive and metering devices for injection devices include a dose display element with a helical dosage scale; an indicating means; a metering member, which can be rotated relative to the indicating means for dose setting; a discharge spring and an advancement member. The dose display element can be screwed relative to the indicating means about a longitudinal axis (L) and a value on the dose scale can be read via the indicating means corresponding to the set dose. The discharge spring causes the advancement member to discharge the product as it moves an overall discharge stroke length (Hg), where the overall discharge stroke length (Hg) comprises a first partial discharge stroke length (H1), during which the dose display element is rotationally secured in relation to the indicating means and where the dose display element can be rotated relative to the indicating means following the first partial discharge stroke length (H1).

The present disclosure is generally directed to a resettable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The drug delivery device comprises a housing, a cartridge holder, releasably attached to the distal end of the housing, a piston rod, engaging a housing insert and a drive member, a dose setting member, guided within the housing to allow rotation of the dose setting member during dose setting and dose dispensing, and a clutch for rotationally coupling the drive member and the dose setting member. The housing insert is rotationally constrained to the housing and is axially movable together with the drive member relative to the housing between a dose setting and dispensing position, and a resetting position. In the dose resetting position. the drive member is rotationally de-coupled from the housing.