A unilaterally driven closed-loop artificial pancreas, includes: a detection module, an infusion module and a program module. The infusion module includes a reservoir, a piston, a screw, a driving unit, a driving wheel provided with wheel teeth, at least one linear actuator and at least one reset unit. The driving unit includes at least one rotating shaft and at least one driving member. The driving member includes a driving end. The driving member rotates around the rotating shaft. The linear actuator and the reset unit respectively connect to the driving member. The program module is connected to the detection module and the infusion module respectively, imported the total daily dose algorithm and the current insulin infusion algorithm. The driving power can be controlled, and it can accurately calculate the TDD value and the current insulin infusion dose.

An injector apparatus includes a housing (10.sup.1, 10.sup.2) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.

A driving mechanism for driving a plunger of an auto-injector to slide relative to a reservoir of the auto-injector is provided and includes a first transmission component, a driving component, a second transmission component, a driving resilient component, a stopping resilient component, a third transmission component, a sliding component and a supporting component. The second transmission component resiliently deforms the stopping resilient component when the first transmission component resiliently deforms the driving resilient component to push the second transmission component to rotate along a first rotating direction. The second transmission component is stopped from rotating along a second rotating direction by the stopping resilient component when the driving resilient component is released to resiliently recover. The third transmission component drives the sliding component to slide when the second transmission component rotates. The supporting component guides the sliding component to slide. Besides, a related auto-injector is provided.

The present invention provides a sensor module adapted to be arranged in a cartridge based drug delivery device between a rotatable piston rod and a cartridge piston for capturing dose data from a dose expelling event, the sensor module (50) extending along a reference axis and comprising: a first module part (51) adapted to engage the cartridge piston and comprising anti-rotation means for establishing a frictional interface to the cartridge to impede rotation of the first module part (51) relative thereto, a second module part (54) adapted to engage the rotatable piston rod, and sensor means (52, 152, 252; 53, 153, 253) adapted to detect an extent of relative rotational motion between the first module part (51) and the second module part (54), wherein the anti-rotation means comprises a plurality of radially outwardly projecting studs (51.1; 351.1; 451.1), each comprising a contact surface (51.8; 351.8; 451.8, 451.9) adapted to establish frictional contact with an interior surface of the cartridge.

The present invention provides a cartridge system (30) for a drug delivery device, comprising a drug cartridge (20) comprising a cartridge body (21) extending along a reference axis between a distal outlet end portion and a proximal rim (21.2), and a displaceable piston (22) arranged in the cartridge body (21) an axial distance from the proximal rim (21.2), an outer cavity (29) thus being formed between the displaceable piston (22) and the proximal rim (21.2), and a guide element (60, 90) comprising a main guide body (61, 91), and a rim interface member (62, 92) adapted to abut or engage the proximal rim (21.2) and thereby cover the proximal rim (21.2) at least partially. The main guide body (61, 91) extends between a first main guide body end (61.1) bordering the rim interface member (62, 92) and a second main guide body end (61.2) and defines a passage for a sensor unit.

The present invention relates to an injection device comprising a torsion spring operatively connected to a dose setting member being adapted to set a dose to be ejected from the injection device. A rotatably mounted display member adapted to display the dose to be ejected in accordance with a setting of the dose setting member is also provided. The rotatably mounted display member is adapted to be rotated over an angle corresponding to at least one revolution of the display member. The display member may be implemented as a dose indicator barrel having numerals arranged along a helical path on an outer surface thereof, or alternatively, as a counting device having two or more display wheels having numerals arranged on an outer surface thereof.

An injection device having a delivery element with an inner thread may be driven by rotation and includes a cylindrical outer wall region, which is substantially smooth. Such features provide a delivery element configured such that it is less intimidating to patients than known threaded rods, and may facilitate easy cleaning. The delivery element may be non-rotatably guided and axially spring-loaded, and may be inserted axially into the housing when the reservoir is replaced. The driving thread element for the delivery element may be mounted in the vicinity of the distal end of the housing.

The present disclosure relates to a safety mechanism for a medicament delivery device for mechanical shock absorption, which safety mechanism has a medicament delivery member sleeve, a housing having a proximal opening arranged to receive the medicament delivery member sleeve, wherein the medicament delivery member sleeve is axially displaceable inside the housing, between an extended position in which a proximal end portion of the medicament delivery member sleeve extends proximally from the housing and a retracted position in which the proximal end portion is received by the housing, wherein the proximal end portion has a resilient structure, enabling compression of the proximal end portion in the distal direction upon impact of an axial force greater than a threshold value.

A drug delivery device comprises a housing (201) and an expelling assembly with a piston rod (220), a drive tube (260) with an outer surface and a scale drum (270) arranged between the drive tube and the housing, the scale drum being coupled to the housing and the drive tube outer surface. The device further comprises a drive spring (255) arranged between the housing and the drive tube, and setting means (280) allowing a user to simultaneously set a dose amount to be expelled and strain the drive spring correspondingly by rotation of the drive tube. The scale drum is coupled to the drive tube via a spline connection, wherein the drive spring is arranged proximally of the spline connection when the spline connection is in its proximal-most position.

An injection device comprises a housing having a first longitudinal axis (L). The injection device further comprises a medicament cartridge holder and a drive assembly including a drive shaft. The drive shaft is arranged around the first longitudinal axis. The drive assembly is capable of providing an axial force for ejecting a dose of medicament from the injection device. The medicament cartridge holder and at least part of said drive assembly are arranged around a second longitudinal axis (LC) which is substantially parallel to but offset from the first longitudinal axis.