The invention relates to an automatic injector device comprising a single-use, disposable, drug delivery assembly comprising a housing and a syringe assembly located at least partially within the housing, said syringe assembly including a plunger, a pre-filled unit-dose drug containing chamber, and needle, said plunger, drug containing chamber and needle being configured and dimensioned to function as an injection syringe; a reusable motorized transmission assembly comprising a housing, a motor and transmission assembly located within the housing, said transmission assembly being configured and dimensioned to engage the plunger of said syringe in the drug delivery assembly and expel said unit dose drug from the drug containing chamber, into the needle and out of the drug delivery assembly; said single-use disposable drug delivery assembly and said reusable motorized transmission assembly are in substantial axial alignment along a longitudinal axis defined by the syringe, plunger, pre-filled unit-dose drug containing chamber, and needle.

The invention relates to a pre-filled syringe, an auto-injector device comprising such pre-filled syringe, a method of administering a pharmaceutical composition with such auto-injector device, and a manufacturing method for such auto-injector device. The pre-filled syringe comprises a container and a needle. The container is filled with a pharmaceutical composition comprising epinephrine, a buffer, and water. The buffer is configured to buffer in a pH range between 3 and 4. The needle is adhered to the container by means of a urethane acrylate or urethane methacrylate acrylic light cure adhesive, which is configured to provide a pull out resistance of the needle relative to the container which is between 30 N to 100 N, preferably between 50 N to 70 N, more preferably greater than 60 N after 90 days exposure to the pharmaceutical composition at 40° C. and 75% relative humidity (RH). In an example, the pharmaceutical composition is for the treatment of an anaphylactic event.

A fluid dispenser device having a reservoir (10) containing fluid; a dispenser head (20) provided with a dispenser orifice (21); and a piston (45; 70) for dispensing at least a portion of the fluid through the dispenser orifice (21). The reservoir (10) is closed in leaktight manner by a closure element (25) before actuation. The device includes a passage (40) for connecting the reservoir (10) to the dispenser orifice (21) during actuation, the passage (40) including a hollow sleeve (41) that is stationary relative to the dispenser head (20), for sliding around the closure element (25) during actuation, so as to open the passage (40).

An injection device is provided herein comprising a container body for holding medication content having a distal end and a proximal end, the container body providing an outward flange at the distal end and a ledge at the proximal end; a piston placed at the proximal end of the container body for sealing and displacing medication content; a push rod placed inside the container body for moving the piston distally; and a connector providing an orifice for medication content delivery, placed at said distal end of said container body. The orifice in the connector provides medication content injection fluid pathway. With modification of the fundamental structure, a number of innovative device designs are created.

A device for administering a fluid can include a cylinder, a piston connected to a piston rod, and a tensioning device connected to the piston rod. In a dispensing procedure, a ramp track is rotated until a roller runs over a transfer region and is accelerated toward the first plateau and, as a result, the piston is moved toward an open dispensing end. The ramp track runs on the face side of a wall extending along a circular path. A cover engages over the ramp track, the driver and the roller and has at least one scraper extending counter to the first direction and extending within the wall as far as the inner side of the wall, and thus scrapes off lubricant located on the inner side from the inner side.

A device for delivery of medicament is presented that has an elongated housing, a container mounted within the housing and adapted to contain liquid medicament, a stopper slidably arranged within said container, and a delivery mechanism comprising a resilient member, a plunger assembly having one end connected to the stopper and a second end being operably connected to the resilient member, a rotatable latch for releasably retaining the plunger assembly in a first position where the resilient member has an accumulated energy, where rotation of the latch releases the plunger assembly such that the accumulated energy is transferred to the plunger assembly for driving the stopper within the container whereby the medicament within said container is delivered to an injection site. After delivery of the medicament a rotator having a hard stop feature aligns with a rib on the protective shield to prevent retraction of the protective shield.

The invention provides an adaptor for a medicament delivery device is configured to enable a set dosage of a medicament to be drawn into and/or expelled from the device, the adaptor including: a body configured to be coupled to the device; an attachment portion movable with respect to the body and configured for attachment with a first part of the device; an engaging portion movable with the attachment portion; and a receiver configured to receive a movement constraint guide (MCG) and facilitate engagement between the engaging portion and the MCG; wherein the MCG includes one or more physical features defining at least an aspect of the set dosage; and wherein activation of said first part of the device to draw and/or expel the medicament is stopped when the set dosage is reached by engagement between the engaging portion and at least one of the one or more physical features of the MCG. The invention thus allows ready control of one or more aspects of dosage administration, which can be the amount of a dose and/or or the repeats of a dose.

A drive unit for an injector includes an elastomeric drive member configured to possess a first elastic potential energy in an elastically stretched state that is releasable to convert the elastic energy to a first biasing force. A selectively releasable plunger rod has a locked position maintaining the elastomeric drive member in the elastically stretched state. A trigger member is biased by a second biasing force into an interlocking position. In the interlocking position, an arm of the trigger member interlocks with a notch of the plunger rod, thereby maintaining the plunger rod in the locked position thereof. The trigger member is selectively movable against the second biasing force to an unlocking position spaced from the notch, thereby releasing the first elastic potential energy into the first biasing force to axially advance the plunger rod and thus advance the piston through the reservoir.

A dmg delivery device includes a housing, a syringe assembly comprising a barrel, a stopper, and a cannula, with at least a portion of the syringe assembly positioned within the housing, a drive assembly configured to move the stopper within the barrel upon actuation of the drive assembly, with at least a portion of the drive assembly positioned within the housing, a lever actuation member moveable between a locked position where actuation of the drive assembly is prevented and a released position where actuation of the drive assembly is allowed, and a needle cover having a pre-use position where the cannula is positioned within the needle cover, an actuation position where the needle cover is configured to actuate the drive assembly, and a post- use position where the cannula is positioned within the needle cover. The needle cover is configured to engage the lever actuation member and move the lever actuation member to the released position when the needle cover is in the actuation position.

A mix and triggering assembly for a medicament delivery device, comprising: a housing structure having a proximal end and a distal end, a delivery member cover, a rotator sleeve, and a triggering member configured to be rotatably locked with the rotator sleeve and the delivery member cover, the triggering member being configured to move axially relative to the rotator sleeve, wherein the delivery member cover, the rotator sleeve and the triggering member are configured to be received by the housing structure, the delivery member cover being configured to extend from the proximal end of the housing structure, wherein the delivery member cover, the rotator sleeve and the triggering member are rotatably arranged relative to the housing structure, wherein the housing structure has a thread structure and the rotator sleeve and the triggering member are configured to be in a threaded connection with the thread structure in a ready to mix position of the triggering member, preventing irrotational axial movement of the triggering member relative to the housing structure towards the distal end of the housing structure, wherein rotation of the delivery member cover relative to the housing structure causes the rotator sleeve and the triggering member to be screwed from the ready to mix position towards the distal end of the housing structure until the triggering member reaches a dose setting position, in which the triggering member is configured to be released from engagement with the thread structure, enabling irrotational axial movement of the triggering member further towards the distal end of the housing structure.