An injection apparatus for injecting a medicament into a patient, the injection apparatus has a stationary head and a movable head that is movable with respect to the stationary head. A needle is attached to a needle holder that is held by the movable head and by the stationary head. When the movable head is urged rearwardly, a front edge of the needle moves forwardly with respect to a front face of the movable head.

An injection device has a housing in which a syringe can be received that has an injection needle, a receiving chamber, a piston and a piston ram, and a control arrangement for controlled actuation of the syringe during an application procedure that includes at least one puncture stroke, one injection stroke and one return stroke. The control arrangement has an actuation element for applying a drive force to a syringe holder which is movable relative to the housing and on which the receiving chamber can be secured, a ram holder which is movable relative to the housing and on which the piston ram can be secured, and a transmission mechanism by means of which the ram holder can be coupled to the actuation element. Provision is made that the transmission mechanism has a toothed gearing by means of which the ram holder can be driven, according to a relative movement of the actuation element with respect to the housing, and which for this purpose has teeth on the housing.

A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.

Components of drug delivery devices can experience large impact forces by a spring-loaded drive mechanism causing a drug reservoir of the delivery device to fracture. For an autoinjector having a reservoir, a plunger rod, a drive mechanism, and a carrier that experiences two impact events when the autoinjector is activated, the mass of the carrier and the mass of the rod is increased by a mass multiplier to reduce the impact pressure at both first and second impacts. The internal pressure of the device decreases in relation to a mass of the impact system 110 to force ratio, where the force is the drive force of the drive mechanism. To reduce the impact pressure from the first event, the mass of the plunger rod may be increased within a range such that the ratio of plunger rod mass to drive force is within a range of approximately a value greater than 0 kg/kgf to approximately 0.05 kg/kgf. To reduce the pressure of the second impact event, the mass of the carrier may be increased so that the ratio of the combined mass of the reservoir, plunger, plunger rod, and carrier to drive force is within a range of approximately a value greater than 0 kg/kgf to approximately 0.15 kg/kgf.

A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.

Devices and methods are provided for delivering an agent into a patient's body using an injection device that includes a drive module and an injector module coupled to the drive module. The drive module includes a canister and puncture mechanism in a first chamber, a plunger in a second chamber communicating with the first chamber, and an actuator that moves the puncture mechanism to cause a puncture pin thereon to penetrate a septum of the canister and cause the gas within the canister to flow through the first chamber around the canister, and into the second chamber. The injector module includes a piston slidably disposed within an agent chamber and coupled to the distal end of the plunger such that, when the plunger moves from a retracted position to an extended position, the piston is advanced within the agent chamber to deliver an agent therein into a patient's body.

In some embodiments a system and method are described for safeguarding a hazard, the hazard, for example a needle point, may be moved between a protected retracted position, an active extended position and/or an intermediate position. Optionally in the retracted position, the hazard may be protected inside a housing. Optionally in the extended position, the hazard may be exposed. Optionally, in the intermediate position the hazard may be partially protected and/or concealed, for example by a shield and/or in an indentation. In some embodiments, compromising a shield causes the hazard to be retracted to the retracted position.

An injector for delivering a medicament includes an outer sleeve, an inner sleeve, and a syringe. The inner sleeve is disposed partially within the outer sleeve. A plunger rod of the syringe is engaged with the outer sleeve in a fixed spatial relationship such that the plunger rod and the outer sleeve translate as a unit. The outer sleeve is configured for axial translation relative to the inner sleeve from a first configuration wherein the inner sleeve extends from the outer sleeve a first distance to a second configuration in which the inner sleeve extends from the outer sleeve a second distance that is less than the first distance. Further, in a third configuration the inner sleeve extends from the outer sleeve a third distance that is greater than the second distance and the inner sleeve is restricted from axially translating with respect to the outer sleeve.

An assembly for an injection device is described. The assembly includes a container containing the medicament and having a cap. The container is sealed by a septum. A sealing element is in contact with an external surface of the cap and a needle is provided for piercing the septum. A needle hub is attached to the needle, where the sealing element is disposed between the external surface of the cap of the container and an internal surface of the needle hub. The assembly transitions from a first state, in which the needle is held away from the septum and a free end of the needle sits in a cavity sealed by the sealing element, to a second state, in which the needle passes through the septum. The seal is maintained throughout transition and when the assembly is in the second state.

The disclosure relates to an automatic medical injection device including a flexible reservoir prefilled with a medical solution. The reservoir includes a needle for injecting the medical solution into a patient's body, and a body removably enclosing the reservoir. The body includes a lower surface adapted to be applied against the patient's skin during an injection of the medical solution, said lower surface including a throughhole adapted for the passage of the needle, and an upper surface opposite to the lower surface, a compression device configured for compressing the reservoir to expel the medical solution through the needle, and an activation button configured to trigger the compression device upon activation by a user.