The present invention relates to an opening and liquid supplying system (100) for pre-filled containers (10, 30) equipped with a supplying end, comprising a coupling element (20), connecting means (6) movable from a first position to a second position, and movable protection means (9); the coupling element (20) has an end (27) closed and suitable for being punched, and first guiding means (21) for guiding the movement of the connecting means (6) movable from the first position, close to the closed end (27), to the second position, apart from such end, and vice versa; the connecting means (6) have engaging means (7) for engaging with the protection means (9) so as to move integrally along a second degree of freedom, different than the first degree of freedom, and first matches (11) for the first guiding means (21). The invention relates also to a respective pre-filled container equipped with such system and the method for realize them.

A drug delivery system for injecting a medicament may include a housing defining a cavity, a container received within the cavity and configured to receive a medicament with the container including a closure, a valve assembly received within the cavity and including a piercing member configured to pierce the closure of the container, and a connector arrangement provided between the container and the valve assembly, the connector arrangement movable between a first, pre-use position maintaining sterility between the closure of the container and the valve assembly and a second, use position permitting fluid communication between the container and the valve assembly.

Embodiments of the invention are directed to flush syringe assemblies comprising an integrated contamination-prevention device integrated with device connector flushing positioned so that the practitioner cannot forget to apply disinfectant. The flush syringe assemblies comprise a barrel with an elongate plunger rod disposed therein and a cap comprising a passageway. The plunger rod includes a stopper of which at least a portion can be embedded in the passageway of the cap to form a plug in the cap. Methods of flushing a vascular access device (VAD) while providing a flush syringe assembly described herein are also disclosed.

An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station.

A pen needle (30, 110) is disclosed for coupling to a delivery device (10) and piercing a septum on the delivery device. The pen needle includes a collar (32, 112) having a side wall (36, 116), an open proximal end (38), and a distal end (40, 118) having a coupling member (50). The pen needle also includes a needle hub (34, 114) having a proximal end (50, 124) and a distal end (58, 126), where the proximal end of the needle hub has a coupling member coupled to the distal end of the collar. The needle hub rotates independently of the collar. A needle (52) extends from the distal end of the needle hub, and a projection (76, 126) extends from the proximal end of the needle hub for piercing a septum (106) of a delivery device. The collar (32, 112) rotates independently from the needle hub (34, 114) so that the collar screws onto the threaded end of the delivery device while the needle hub does not rotate and the projection advances to pierce the septum (106) without rotating.

A delivery adapter which may be used as an interface between a syringe and a catheter hub is described.

The present subject matter includes a cannulated delivery device made of an adapter configured to connect to a syringe; a delivery device tip configured to connect to a dosing chamber; an internal chamber of the cannulated delivery device connecting the adapter and to the delivery device tip, and the internal chamber defining a dose pathway and a system and method of use of the device to increase dosage delivery to a patient while maintaining a sterile fluid pathway.

The present relates to a filter needle coupled between a fixation member having a needle for injecting a medical fluid after filtering foreign substances contained in the medical fluid and a disposable syringe, the filter needle includes an outer housing having a front end portion to which the fixation member is coupled and a rear end portion to which the disposable syringe is coupled and a filtering unit which is disposed inside the outer housing, and in which a medical fluid supplied from the fixation member to the disposable syringe is passed through as is, while a medical fluid supplied from the disposable syringe to the fixation member is filtered.

A syringe barrel includes: a hollow body portion that is configured such that a gasket is slidably insertable therein. The syringe barrel is made of a resin that has a total light transmittance of 80% or more. A scale is disposed at an inner circumferential surface or an outer circumferential surface of the body portion, the scale being visible from an outside of the syringe barrel and being configured to indicate a liquid amount. The scale is formed by (i) a stepped structure having a step height in a range of 0.001 to 0.15 mm in a radial direction, and/or (ii) an embossment.

Improved systems and methods for medicine delivery, and in particular, improved insulin pen needles and related devices are provided. Smart injection devices record and transfer data including medicine level, delivered dose, dose confirmation, and dose time and date. Additional data captured may include glucose concentration, insulin level, carbohydrates ingested, stress level, exercise, blood pressure, and glucose high and low excursion events. Various means of data collection and analysis are provided and systems can identify and flag patients who require intervention. Smart sleeves and add sensing capability to standard insulin pens. Pen needles are provided with sensing capability to confirm and measure doses delivered by insulin pen. A two-part pen cap include a primary sleeve that connects to the insulin pen and an end cap that provides for capturing the time of dose delivery, and monitoring the hold time for a dose delivery after plunger movement.