An embodiment relates to a transdermal drug delivery system comprising a patch comprising a) a cartridge comprising a drug; b) a bio-sensor and a non bio-sensor; c) an active delivery pad comprising an electrode for delivery of the drug into a tissue via iontophoresis; d) a power source of electrical energy connected to the electrode; e) a microcontroller configured to control a release of the drug wherein the patch is attached to the tissue via an adhesive pad, and optionally top of patch is covered with a sheet; wherein the bio-sensor is configured to detect a physiological parameter; wherein the non bio-sensor is configured with a software to control working of the patch.

A wearable device can include a sweat collection unit, and optionally, a sweat stimulation unit. The sweat collection unit includes at least one microfluidics channel to collect sweat from a user, a chamber to hold the sweat, and a loading chamber with sweat collection paper that attracts the sweat through the chamber. A chloride sensing unit located within the chamber includes a gold working electrode and a counter electrode that can determine if enough sweat is in the chamber and, if enough, the chloride concentration of the sweat can be determined based on electrochemical reactions in response to electrical signals applied through the electrodes. A controller of the device can notify a user to trigger the sweat stimulation unit if not enough sweat is in the chamber.

Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

An electrode for electrical stimulation of tissue and administration of substances to the tissue includes a first conductive plate and a second conductive plate surrounding the first conductive plate. The first conductive plate and the second conductive plate are separated from each other. An activation signal is applied to the first conductive plate to generate an electric field inducing a current in the tissue and applying an electric potential to the second conductive plate to obtain an electric potential differential with respect to the first conductive plate. The electric potential of the second conductive plate forces the current induced by the first conductive material plate to penetrate the surface of the tissue in contact with the conductive plates and prevents the induced current from flowing on the surface of the tissue.

An electrical discharge irrigation device includes a power source to produce power of a first voltage, a circuit coupled to the power source to convert the power of the first voltage to power of a second voltage where the second voltage is higher than the first voltage, a trigger to activate the circuit, an igniter coupled to the circuit to produce a spike, an electrical charge storage component coupled to the igniter the electrical charge storage component becoming conductive and storing an electrical charge after receiving the spike, and an output tip. The output tip includes an electrode and insulating material as an outer layer.

There is disclosed systems and methods for non-invasive delivery of an agent to biological tissues. Delivery of the agent to the tissues can be by one or more modalities. In some embodiments the systems and methods use agent carrier body including a tissue contacting surface for non-invasively engaging tissues under treatment. The tissue contacting surface can be at least partly defined by a plurality of protrusions that are in fluid communication with one or more reservoirs forming part of the agent carrier body. The protrusions may extend outward from an inside of a void and terminate at said tissue contacting surface.

Electromechanical substance delivery devices are provided which implement low-power electromechanical release mechanisms for controlled delivery of substances such as drugs and medication. For example, an electromechanical device includes a substrate having a cavity formed in a surface of the substrate, a membrane disposed on the surface of the substrate covering an opening of the cavity, and a seal disposed between the membrane and the surface of the substrate. The seal surrounds the opening of the cavity, and the seal and membrane are configured to enclose the cavity and retain a substance within the cavity. An electrode structure is configured to locally heat a portion of the membrane in response to a control voltage applied to the electrode structure, and create a stress that causes a rupture in the locally heated portion of the membrane to release the substance from within the cavity.

A localised transdermal iontophoretic drug delivery system which controls localised transdermal drug delivery doses, transdermal drug delivery depths and transdermal drug delivery speeds is provided. The system includes a power supply, a current driving assembly, an optional switch matrix or multiplexer, and electrode assemblies or an electrode assembly array. The localised transdermal iontophoretic drug delivery system accurately controls a drug delivery current distribution between any electrode combination, so as to locally control a transdermal drug delivery dose, a transdermal drug delivery depth and a transdermal drug delivery speed, in order to implement accurate drug delivery to a user's skin.

A method and apparatus to treat hyperhidrosis is provided in which a battery provides a milliampere electrical current to the inside of a waterproof glove containing water and sealed to the user's arm so that circulation is not unduly restricted while the user can raise the water-filled gloves and hands above the user's head without leaking. A tapered portion on the proximal end of each glove is folded inside the glove to seal against the user's arm to form a pocket between the tapered portion which seals against the user's arms, and part of a wrist portion of the glove located radially outward of the tapered portion. When the user's gloves and hands rotate upward, water collects in the pocket(s) while the tapered portion provides a leakproof seal, thus allowing manual manipulation while wearing the water-filled gloves.

A transdermal delivery system (1) configured to deliver an active agent to human or animal tissue, comprising a penetrative electrode (2) of one polarity that provides an electrical contact (3) beneath the stratum corneum (20); a surface electrode (4) of the opposite polarisation to that of the penetrative electrode (2) that provides an electrical contact to the external surface of the skin (21) on the opposite side of the stratum corneum (20) to the electrical contact (3) of the penetrative electrode (2); a dispenser (5) configured to deliver of an active agent to the external surface of the skin (21) adjacent to an electrical contact of the surface electrode (4); a method of delivering the active agent to the tissue of a human or animal body using the transdermal delivery system (1) and an electrode assembly (10) for use in preparing the transdermal delivery system (1).