The disclosure provides a biological brain-computer interface comprising genetically modified cells engrafted onto an adult mammal (e.g., mouse) above cortical layer 1, forming an artificial cortical layer termed layer zero (L0). Following engraftment, L0 goes through a developmental process characterized by synchronous waves of activity that gradually recede to resemble spontaneous cortical activity. Axons and dendrites from L0 nondestructively infiltrated the host cortex and formed synaptic connections necessary for bidirectional communication with the brain.

Cortical network structure that mediates response to brain stimulation, and associated systems and methods are disclosed herein. In one embodiment, a method for brain stimulation includes: delivering an input stimulus to an area of the brain, via a cortical implant; in response to delivering the input stimulus, generating neural signals in the brain; and generating a predicted outcome of the input stimulus. The predicted outcome is based on a set of data derived from a model that combines: protocol features that are brain agnostic, and network features that are based on interactions between neural nodes of the brain.

Disclosed are devices, electrodes, systems, methods, and other implementations, including a subdural sound that includes an elongated body configured to be placed within a subdural space of a brain area of a patient, with the elongated body defining a receiving channel to receive a displaceable electrode to be tangentially placed at a target site in the subdural space. The subdural sound further includes a curved tip at a distal end of the elongated body, the curved tip configured for angled insertion into the subdural space of the patient to advance the elongated body to the target site in the subdural space.

An implantable medical device (IMD) is described capable of determining whether a patient is susceptible to freezing of gait events during ambulatory movement without the patient demonstrating an episode of freezing of gait. In one example, the IMD senses, via one or more electrodes, a bioelectrical signal of a brain of the patient while the patient performs movement associated with freezing of gait. The IMD determines, based on the bioelectrical signal, whether the patient is susceptible to freezing of gait while the patient is not experiencing an episode of freezing of gait. Further, upon detecting the movement associated with freezing of gait, the IMD delivers electrical stimulation therapy to the patient configured to suppress freezing of gait.

Stimulation of nervous system components by electrodes can be used in many applications, including in the operation of brain-machine interfaces, bidirectional neural interfaces, and neuroprosthetics. The optimal operation of such systems requires a means of accurately measuring neural responses to such stimulations. However, currently the measurement of neural responses is difficult due to heavy stimulation artifacts arising from stimulatory pulses. The invention encompasses novel methods of estimating stimulation artifacts in measurements attained by recording electrodes and the effective removal of these artifacts. This provides improved neural recording systems and enables the deployment of closed-loop neural stimulation systems.

A system provides a burr hole cap assembly configured to secure a position of a lead implanted through a burr hole in a cranium of a patient. One or more electrodes are coupled to one or more components of the burr hole cap assembly. The one or more electrode is disposed within the burr hole cap assembly for sensing signals within a brain of the patient or stimulating a portion of the brain of the patient.

The present disclosure provides advantageous post and partition assembly that is configured and adapted to promote modularity and withstand the harsh environment of central sterile processing processes. Modular post assembly may be removed and relocated on tray without additional fasteners or components. Tray and bracket assembly may further provide identification features to correctly associate cataloged reusable medical devices to identified trays.

Methods, systems, and compositions are provided for implanting an implantable device into a biological tissue (e.g., muscle, brain). A subject implantable device includes: (i) a biocompatible substrate, (ii) a conduit (e.g., an electrode, a waveguide) that is disposed on the biocompatible substrate, and (iii) an engagement feature (e.g., a loop) for reversible engagement with an insertion needle. The biocompatible substrate can be flexible (e.g., can include polyimide). The implantable device is implanted using an insertion needle that includes an engagement feature corresponding to the engagement feature of the implantable device. To implant, an implantable device is reversibly engaged with an insertion needle, the device-loaded insertion needle is inserted into a biological tissue (e.g., to a desired depth), and the insertion needle is retracted, thereby disengaging the implantable device from the insertion needle and allowing the implantable device to remain implanted in the biological tissue.

Presented herein are techniques for providing tinnitus relief to recipients via an implantable arrangement. In accordance with embodiments presented herein, an implantable medical device, such as implantable tinnitus therapy device, auditory/hearing prosthesis, etc., comprises one or more implantable sensors configured to be implanted in a recipient. The one or more implantable sensors are configured to detect body noises of the recipient. The implantable medical device is configured to classify/categorize the one or more body noises and set, select, or otherwise determine a tinnitus therapy for the recipient based on the classification of the one or more body noises.

A system including a power source, one or more stimulating devices for stimulating the visual cortex of a user to present a perceived virtual image responsive to the stimulating, one or more sensing devices for sensing electrical signals in the motor and/or pre-motor cortex of the user and a processor/controller connected to the stimulating and sensing devices and programmed to sense signals from the motor and/or pre-motor cortex of the user. The sensed signals result from the user performing a movement and/or intending to perform a movement and/or imagining the performing of a movement and are used to interact with the presented virtual image. The processor/controller processes the sensed signals to obtain computed data indicative of a user's interaction with the virtual image, and performs a general computing task responsive to the computed data.