A set of shielded coils for wireless power transmission into a medical implant is described in which the external, power transmission coil is blocked at least on one side by a shield with a broken ring and radial fingers while the power receiver coil inside the medical implant is surrounded by a shield having a broken ring connecting radial fingers and ribs around its circumference. The finger and rib configurations minimizes eddy currents in the shields. A ground plane of the implant's internal circuitry, which is within the shield along with the receiver coil, can cap off the cupped receiver shield to form a Faraday cage with it. The metal or other conductive shielding prevents large electric fields from the coils from penetrating into the tissue of the subject while simultaneously allowing magnetic fields inductively couple the coils for charging. An implant with sensitive electrodes that measure minute voltages from a brain or other tissues is protected from capacitively driven voltage swings or other transients during charging.

A device selected from microelectrode, temperature sensor, optical sensor, optical fibre, temperature control element, and microdialysis probe for insertion into soft tissue comprises a body with a distal terminal section and a layer of an agent such as gelatin capable of forming a gel with aqueous body fluid on the terminal section. The terminal section and the gel-forming layer have a temperature of more than 30° C. below body temperature during a period of time prior and up to insertion. Also disclosed is method of insertion, an insertion assembly and a use of the device.

Systems and techniques for wireless implantable devices, for example implantable biomedical devices employed for biomodulation. Some embodiments include a biomodulation system including a non-implantable assembly including a source for wireless power transfer and a data communications system, an implantable assembly including a power management module configured to continuously generate one or more operating voltage for the implantable assembly using wireless power transfer from the non-implantable assembly, a control module operably connected to at least one communication channel and at least one stimulation output, the control module including a processor unit to process information sensed via the at least one communication channel and, upon determining a condition exists, to generate an output to trigger the generation of a stimulus.

The present invention relates to a syringe-injection-type brain signal measurement and stimulation structure, and a syringe injection method therefor, and provides a structure including a high-performance flexible element capable of minimizing a skull opening when inserted into the brain. Particularly, the present invention comprises: a flexible element, which includes a contact part making contact with a surface of a cortex so as to measure a signal generated in the brain or transmit an external stimulus to the brain, a transmitting/receiving part positioned between a skull and a skin, and a connection part for making a connection between the contact part and the transmitting/receiving part; and an integrated circuit connected to the transmitting/receiving part so as to transmit/receive a signal,

A method of providing neuromodulation treatment to a patient includes both an assessment procedure prior to the application of magnetic stimulation signal to the patient during a treatment period of time. The assessment procedure is completed prior to the treatment period of time and senses an electroencephalogram (EEG) signal of the person and then an evaluates the EEG signal to obtain a measure of a patient's endogenous brain activity within a selected EEG band of the EEG signal of the patient. A control subsystem adjusts a stimulation protocol parameter used in the generation of the magnetic stimulation signal based upon the measure of a characteristic of the patient's endogenous brain activity obtained during the assessment procedure. The adjusted magnetic signal is then applied to the head of the patient for providing treatment to the patient patient's brain.

Systems, apparatus, and methods for treating medication refractory epilepsy are disclosed. In one embodiment, a method of treating epilepsy is disclosed comprising detecting, using a first electrode array coupled to a first endovascular carrier, an electrophysiological signal of a subject. The method further comprises analyzing the electrophysiological signal using a neuromodulation unit electrically coupled to the first electrode array and stimulating an intracorporeal target of the subject using a second electrode array coupled to a second endovascular carrier implanted within a part of a bodily vessel superior to a base of the skull of the subject.

A device to make multiple, simultaneous measurements of electrical activity on neural, muscular and other animal cells. The invention discloses multiple electrodes at fixed position on a supporting structure and multiple wires to connect the electrodes to one or more measuring devices. The electrodes are preferentially closed spaced, to allow for small spatial discrimination between measurement points. The electrodes and the wires are selected by binary addresses. The device is also capable of injecting electrical stimulation using electrodes not in use for measurements. An injected electrical stimulation at a first location may be created to measure the effect of a well-known event at another location or locations, near or far away.

Disclosed are wireless stimulation electrode for excitable tissue. In one example, a wireless stimulation electrode includes a body made of biocompatible photovoltaic and/or photothermal material; and at least one coating surrounding at least a portion of the body, wherein at least one critical dimension of the body is substantially smaller than a target cell. Also disclosed are systems and methods for stimulating excitable tissue.

An implantable device has a hermetically sealed enclosure, an electronic device within the hermetically sealed enclosure, and a plurality of feedthrough conductors in mechanical contact with the hermetically sealed enclosure and exposed outside of the hermetically sealed enclosure. The implantable device also has a flexible substrate with a plurality of therapy contacts, and a plurality of continuously conductive elements extending along the flexible substrate from the array of therapy contacts and terminating at a plurality of connection pads. Each of the continuously conductive element is integral with at least one therapy contact and at least one connection pad to electrically communicate the noted therapy contact(s) and the noted connection pad(s). The thickness of each continuously conductive element may be between about 5 and 190 microns. The implantable device also has a plurality of mechanical welded couplings that each couple at least one of the connection pads.

The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain. The disclosure further comprises a system for using these arrays to generate time-varying electric fields to stimulate the visual pathways of the brain, including the optic radiations and the occipital cortex, in ways that lead to visual perception.