Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system is configured to receive information representing a plurality of signals sensed from a tissue of a patient via a plurality of electrode combinations, wherein the plurality of electrode combinations comprises different electrode combinations comprising electrodes disposed at different positions of the lead implanted in the patient, determine one or more features from the information representing the plurality of signals, and compare the one or more features to a plurality of templates, each template of the plurality of templates representing respective locations of a signal source within the tissue. The system may then determine, based on the comparison of the one or more features to the plurality of templates, an estimated location of the signal source with respect to the lead.

This document discusses a medical system for coupling to one or more implantable electrodes. The medical system includes a sensing circuit, memory, and processing circuitry. The sensing circuit is configured to sense one or more neural signal representative of neural activity of a subject when connected to an implantable electrode of the one or more implantable electrodes, and the memory is to store a reference signal that is representative of a neural response associated with a state of arousal at or near an anatomical location of the implantable electrode. The processing circuitry is configured to compare the one or more sensed neural signals to the reference signal, and to determine a depth of anesthesia of the subject according to the comparison of the one or more sensed neural signals and the reference signal.

Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic transducer configured to emit an ultrasonic backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic transducer; (b) an integrated circuit comprising (i) a variable frequency power supply electrically connected to a first electrode and a second electrode; (ii) a signal detector configured to detect an impedance, voltage, or current in a circuit comprising the variable frequency power supply, the first electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic transducer based on the detected impedance, voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject.

A fully implanted integrated, wireless, flexible CMOS chip for long-term recording and stimulation of the brain in vivo and methods of manufacturing thereof are provided. The chip is an entire biocompatible system and can include the dense surface electrode array, the underlying CMOS integrated circuit architecture, integrated wireless powering and telemetry. Furthermore, miniaturization through manufacturing, permits implantation of the chip under the skull and other regions of interest with no wires or connections. Furthermore, these devices and systems can operate under a dual modality such as to be able to record and stimulate the surface of the brain and/or tissue in which they have been implanted.

Synchronized stimulation of cardiac tissue can be implemented by implanting two or more rectifier-based AM receivers into different positions within a subject's heart. Each receiver is tuned to a different frequency, and generates an output signal that is capable of stimulating cardiac tissue when a signal at the corresponding tuned frequency arrives at the receiver. An AM transmitter can activate any given one of the receivers by transmitting a signal into the subject's body at the proper frequency. A controller controls the transmitter by commanding the transmitter to transmit pulses of AC at different frequencies at different times, so that when those pulses are received by the correspondingly-tuned receivers, each of the receivers will generate respective output signals that stimulate respective parts of the heart at respective times to promote improved cardiac performance.

A method and system are described for, based upon a plurality of previously-acquired directional LFP signals measured in a plurality of different directions at a directional sensor lead located in a predetermined region of a patient's brain, determining optimised patient-specific programming parameters for programming a directional stimulation lead with parameters for stimulating the said region. The method comprises a first step of determining, over at least one predetermined frequency range, a power-frequency variation curve of each of the directional LFP signals, a second step of identifying frequency peaks in the power-frequency variation curves, a third step of detecting one of the identified frequency peaks at which a maximum difference in signal power between the directional LFP signals occurs, and a fourth step of calculating a plurality of directional stimulation weighting factors on the basis of the relative signal powers of the directional LFP signals at the detected frequency peak.

The present disclosure provides systems and methods for assembling a subassembly for use in manufacturing an implantable device header. A method includes placing a first split web into a top platen, placing a second split web into a bottom platen, placing a conductor assembly and an antenna assembly in the bottom platen on top of the second split web, compressing the top and bottom platens together, heating the top and bottom platens until a predetermined temperature and a predetermined pressure are reached, such that first split web is fused to the second split web to form the subassembly, separating the top and bottom platens, and removing the formed subassembly.

A computer implemented system and method facilitates a cycle of generation, sharing, and refinement of volumes related to stimulation of anatomical tissue, such as brain or spinal cord stimulation. Such volumes can include target stimulation volumes, side effect volumes, and volumes of estimated activation. A computer system and method also facilitates analysis of groups of volumes, including analysis of differences and/or commonalities between different groups of volumes.

Implantable medical devices have modular lead bores that are constructed from individual lead bore modules. A given modular lead bore utilizes the number of individual lead bore modules necessary for the particular implantable medical device. Each lead bore module has a lead bore passageway and a feedthrough passageway. An electrical contact is present within the lead bore passageway of each lead bore module and the electrical contact is aligned to the lead bore passageway of a lead bore module. Hermetic feedthrough assemblies are also present within the lead bore passageway of each lead bore module. A feedthrough pin passes through a hermetic feedthrough assembly within a feedthrough passageway of each lead bore module. Each feedthrough pin is electrically coupled to a corresponding electrical contact and the medical device circuitry.

A charging system for an Implantable Medical Device (IMD) is disclosed having a charging coil and one or more sense coils preferably housed in a charging coil assembly coupled to an electronics module by a cable. The charging coil is preferably a wire winding, while the sense coils are preferably formed in one or more traces of a circuit board. One or more voltages induced on the one or more sense coils can be used to determine one or more parameters (magnitude, phase angle, resonant frequency) indicative of the position between the charging coil and the IMD, which position may include the radial offset and possibly also the depth of the charging coil relative to the IMD. Knowing the position, the power of the magnetic field produced by the charging coil can be adjusted to compensate for the position.