A biostimulator, such as a leadless cardiac pacemaker, including an electrical feedthrough assembly mounted on a housing, is described. An electronics compartment of the housing can contain an electronics assembly to generate a pacing impulse, and the electrical feedthrough assembly can include an electrode tip to deliver the pacing impulse to a target tissue. A monolithically formed electrode body can have a pin integrated with a cup. The pin can be electrically connected to the electronics assembly, and the cup can be electrically connected to the electrode tip. Accordingly, the biostimulator can transmit the pacing impulse through the monolithic pin and cup to the target tissue. The cup can hold a filler having a therapeutic agent for delivery to the target tissue and may include retention elements for maintaining the filler at a predetermined location within the cup.

Systems, apparatus, methods and computer-readable storage media that facilitate monitoring the integrity of telemetry connectivity between an implantable device and an external device are provided. In one embodiment, an implantable device includes a monitoring component that monitors advertisement signal information identifying an amount of advertisement signals transmitted to the external device within a defined time period, and telemetry session information identifying an amount of the telemetry sessions that are established between the external device and the implantable device within the defined time period. A connectivity assessment component of the implantable device further determines whether a telemetry connectivity problem exists between the external device and the implantable device based on a degree of miscorrelation between the advertisement signal information and the telemetry session information.

Systems, apparatus, methods and computer-readable storage media that facilitate monitoring the integrity of telemetry connectivity between an implantable device and an external device are provided. In one embodiment, an implantable device includes a monitoring component that monitors advertisement signal information identifying an amount of advertisement signals transmitted to the external device within a defined time period, and telemetry session information identifying an amount of the telemetry sessions that are established between the external device and the implantable device within the defined time period. A connectivity assessment component of the implantable device further determines whether a telemetry connectivity problem exists between the external device and the implantable device based on a degree of miscorrelation between the advertisement signal information and the telemetry session information.

An implantable drug eluting medical device includes a polymer substrate having a surface, a first plurality of nanofibers, and at least one antimicrobial drug. Each of the first plurality of nanofibers includes a first portion interpenetrated with the surface of the substrate to mechanically fix the nanofiber to the substrate, and a second portion projecting from the surface. The at least one antimicrobial drug is disposed within or among the second portion of the first plurality of nanofibers.

A method of forming an implantable electrode having electrode contacts on an electrode carrier having a coating includes providing a solution of silicone and dexamethasone dissolved in a solvent, applying the solution to the electrode carrier or to a substrate, and subjecting the solution to a two-step heat treatment process that includes a first heat treatment between about 50 and 90 C. for about 1 to 3 hours and a second heat treatment at an elevated temperature between 90 C. and 140 C. for about 2 hours in order to form the coating.

A system for selecting a sensitivity level for adjusting an intensity setting for therapy provided to a patient includes one or more processors and one or more processors coupled to the memory. The one or more processors are configured to receive an indication of an input to adjust an intensity setting related to the therapy provided to the patient and determine a sensitivity level for adjustment of the intensity setting based on an efficacy of the therapy provided to the patient. The one or more processors are further configured to determine an updated intensity level for the intensity setting based on the sensitivity level and the input to adjust the intensity setting and output an instruction to cause a medical device to provide the therapy at the updated intensity level.

Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.

According to an embodiment, a medical device is disclosed. The medical device includes an external unit and an implantable unit. The external unit includes an electronic unit operationally coupled to a transmitter coil that is configured transmit power and/or data signal over a wireless transcutaneous link, a coil unit comprising a loop structure with the transmitter coil being wound around and along at least a part of length of the loop structure, and a fixation unit configured to attach the loop structure to a user's body i) proximal to an implantable receiver coil that is configured to be implanted within a body part, and ii) around a body part of a user such that a part of the body part is positioned in a hollow section of the loop structure. The implantable unit includes the implantable receiver coil configured to receive the power and/or data signal over the wireless transcutaneous link, a processing unit configured to i) process the received data signal to control functionalities of at least one of the components of the implantable unit, and/or ii) utilize the received power for operation of at least one of the components of the implantable unit. The wireless transcutaneous link includes a coupling between the transmitter coil and the receiver coil, and when the loop structure is attached using the fixation unit, at least a substantial number of magnetic field lines generated in response to excitation of the transmitter coil passes through the implantable receiver coil.

Flexible implantable subcutaneous heart device (HD) structure, including a flexible device body, at least one flexible lead and at least one respective transition unit, the transition unit for respectively coupling each flexible lead to the flexible device body, the flexible device body including a plurality of inner components and a respective plurality of hollow outer units, the hollow outer units for encasing and protecting the inner components, each one of the hollow outer units including at least one hollow rigid element and a hollow flexible element, the hollow flexible element coupled with the hollow rigid element for enabling the outer unit a degree of flexibility, wherein the hollow flexible element is covered with a covering and wherein the flexible device body is covered with a polymer.

An assembly for an implantable device can be made from polyurethane and can incorporate one or more radiopaque agents and one or more elutable drug components into a polymeric lead tip. The assembly can be machined or injection molded and can be configured, for example, as a housing for an active fixation lead or as an electrode base supporting a foil electrode.