A neuromimetic stimulating apparatus includes a feedback detector configured to detect a feedback signal from a target to be stimulated, a controller configured to analyze a waveform of the detected feedback signal and determine a parameter based on the analyzed waveform of the detected feedback signal, and a signal generator configured to generate a stimulus signal corresponding to the detected feedback signal based on the determined parameter.

A system, device, and method for transcutaneous nerve stimulation such as facial nerve stimulation, and in particular, to using transcutaneous nerve stimulation for artificially eliciting eye blink, such as with humans with acute facial paralysis (Bell's palsy or Dry Eye syndrome), is disclosed. A battery-operated wearable device may employ a pulse generator for periodically and automatically generating bursts train of asymmetrical Bi-Phasic square pulses. The output pulses are fed to two electrodes that are attached to the skin of the treated person to stimulate the facial nerve for eliciting blinking at a rate that mimics normal blinking operation. The device may include a sensor and a wireless connection, and the parameters of, or the activation of, the generated bursts may be controlled by the sensor output, by human user control, or by data received from the wireless network. Further, the device may transmit status to the wireless network.

A system for moving or assisting in movement of a body part of a subject, as well as a rehabilitation system including such a movement assistance system, includes a body part interface configured to be secured to the body part, and a motor-actuated assembly connected to the body part interface to move the body part interface to cause flexion or extension movement of the body part. A force sensing module is configured to measure forces applied between the body part interface and the motor-actuated assembly to ascertain at least one of volitional flexion and volitional extension movement of the body part by the subject, among other functions that may be implemented in movement assistance and rehabilitation systems using the disclosed force sensing module designs.

Methods of treating cancer are provided. In some instances, the method comprises applying alternating electric fields to the abdomen of the subject at a frequency of 100 to 500 kHz, administering a checkpoint inhibitor to the subject, and administering systemic cancer therapy to the subject. In some instances, the cancer is pancreatic ductal adenocarcinoma.

A patient monitoring system within an Electroconvulsive Therapy (ECT) device includes a patient monitoring channel including a first electrode and a second electrode, with each electrode coupled to a respective lead. The monitoring system also includes an Alternating Current source structured to inject a test current to the first electrode lead or the second electrode lead and a differential amplifier structured to measure differences between signals received from the first electrode lead and the second electrode lead. Related methods include evaluating a quality of an electrode contact with a skin surface by injecting a lead of the electrode and one input of a differential amplifier with a known electrical current, comparing a difference between an electrical signal received from the lead of the injected electrode as well as from a lead of a passive signal electrode, and evaluating the compared difference.

The invention described herein provides for a portable autonomic nerve system stimulation device that may operate as an “open-loop” or “closed-loop” stimulation system and includes in some embodiments a paired therapy for a disease or condition. Embodiments of the inventive device include at least one stimulation circuit for the generation and delivery of a stimulation, at least one biological signal monitoring apparatus for monitoring a biological state of a user wearing the device, at least one controller in electrical communication with the stimulation circuit and at least one power supply for providing power to the controller and stimulation circuit. Aspects of the invention provides for a portable autonomic nerve system stimulation device which may be worn in the ear, or about the head, of a subject, patient or user.

An electric device for skin treatment, includes: a needle body including needles for drug injection and electrical stimulation treatment and a needle printed circuit board (PCB) connected to the needles; a needle cap provided at a first end of the needle body and having a needle hole through which the needles passes; and a handpiece body having a first end detachably connected to a second end of the needle body. The handpiece body includes: a connection PCB to which a connection member configured to be electrically connected to the needle PCB is coupled; and a connection PCB cable configured to be electrically connected to the connection PCB.

A neurostimulation system is disclosed for providing treatment to a patient during a therapy session. The neurostimulation system includes a neurostimulator for transmitting magnetic or electrical signals based upon a treatment program. A programmer is connected to the neurostimulator to set a treatment session parameter value to calculate a therapy compliance value. A compliance module is connected to the neurostimulator and the programmer to calculate and store a therapy compliance value. A control module is connected to the compliance module, the programmer and the neurostimulator and determines whether the therapy compliance value is within a range of the treatment program. The neurostimulator transmits electrical or magnetic signals to the patient in a treatment session only if the therapy compliance value meets a compliance criteria.

Rehabilitating an impaired body part of a subject such as a stroke patient includes systems, devices, and methods using an orthosis system configured to attach to the impaired body part and to move or assist in movement of the impaired body part. A control system is configured to operate the orthosis system in a mode in which the orthosis system first allows the subject to move volitionally or attempt to move volitionally the impaired body part in a predefined motion and then operates to move or assist in the predefined motion of the impaired body part. Additional modes of operation include a brain computer interface mode of operation and a mode in which the orthosis system operates in a continuous passive mode of operation comprising a plurality of repetitions of an exercise to move the impaired body part.

A system includes a collar that is worn around a neck of the user. A stimulator is coupled to the collar such that the stimulator is positioned adjacent to an airway of the user. The sensor is coupled to the collar and configured to generate data associated with the airway of the user. The memory is coupled to the collar and storing machine-readable instructions. The control system is coupled to the collar and includes one or more processors configured to execute the machine-readable instructions to determine, based at least on an analysis of the generated data, that the user is currently experiencing an apnea event. In response to the determination, the control system causes the stimulator to provide electrical stimulation, at a first intensity level, to one or more muscles of the user that are adjacent to the airway to aid in stopping the apnea event.