The present disclosure relates to a system for neuromodulation and/or neurostimulation, for the treatment of a subject. The system comprises a stimulation controller, a stimulation pattern storage means including stimulation data connected to the stimulation controller, an electrical stimulation device and electrical interface between the electrical stimulation device and the subject, the electrical interface being connectable with a bio-interface of the nervous system of the subject. The stimulation data are pre-programmed patterns comprising spatial and temporal components, The stimulation controller sends configuration signals on the basis of the stimulation data to the electrical stimulation device such that via the electrical interface electrical stimulation is provided to the bio-interface, wherein the electrical stimulation provided is characterized by stimulation parameters that vary over time in a pre-programmed manner.

Systems and methods for high-bandwidth, minimally invasive brain-computer interfaces (BCIs) are disclosed. The BCIs are configured for deployment and operation in conjunction with a comprehensive interventional electrophysiology procedural suite. Three primary methods of minimally invasive electrode array delivery are disclosed: (1) cortical surface delivery, (2) ventricular delivery, and (3) endovascular delivery. Additionally, systems and methods for interacting with such high-bandwidth electrode arrays are discussed, including real-time imaging, signal processing, and neural decoding. Systems and methods for architectures for accelerating the underlying computational processes (such as graphics processing units or tensor processing units) are also discussed. Multiple applications of BCIs are discussed, with emphasis on restoration, rehabilitation, and augmentation of neurologic function.

Systems are provided for compact implantable multi-site optical stimulation and/or combined electrical and optical stimulation of spinal cord, brain, dorsal root ganglion, peripheral nerve, or other tissue. High-power LEDs or other light-emitting elements are provided at the site of stimulation, avoiding complex fiber optics or other means for coupling light from a distant laser along a stimulator to target tissue. Colocation of electrical stimulation contacts and light emitters allows the same tissue to be stimulated electrically and optically, at the same time or according to an alternating or other pattern of combined electrical and optical stimulation. These stimulators can be used as part of permanently implanted systems and/or as part of temporary, percutaneous stimulator systems. Optical and/or combined electrical and optical stimulation can be provided for pain relief, to encourage wound healing in nervous or non-nervous tissue, or to provide other clinical benefits.

A method for assisting and tracking a user with a neurological disorder includes receiving, from a user interface, a selection of a physical activity that the user wishes to perform. The method further includes sending a control signal to a neurostimulation device, the control signal including instructions for the neurostimulation device to implement a neurostimulation therapy regimen corresponding to the selected physical activity that the user wishes to perform. The method also includes receiving an activity feedback signal from at least one sensor, the activity feedback signal including information regarding performance of the selected physical activity when performed by the user. The method further includes sending a monitoring signal to a remotely located caregiver device, the monitoring signal including activity data derived from the information regarding performance of the selected physical activity.

Techniques for providing therapy to a patient via electrical stimulation are described. The techniques include, for example, determining, relative to a start time of providing the electrical stimulation, one or more efficacy times that correspond to an efficacy indicator, determining, according to the efficacy times, efficacy data items for the patient, comparing the efficacy data items with the efficacy indicator, and generating, based on the comparison, a prediction of an expected response to the therapy manifesting in the patient at a prospective time.

The present invention relates to an electrical nerve stimulator configured to deliver an electrical signal to a user to entrain Mu-band neural oscillations and/or Beta-band neural oscillations. The electrical nerve stimulator may be used in the treatment of neurological conditions associated with desynchronization of neural oscillations, such as Tourette's syndrome. The electrical nerve stimulator may be wearable on a wrist of a user, and may be configured to deliver rhythmic stimulation at a frequency falling within the same frequency range of Mu-band or Beta-band neural oscillations. The invention provides a convenient means of treating conditions such as Tourette's syndrome without the need for specialist medical equipment or facilities. Also disclosed is a method of delivering an electrical signal to a user to entrain Mu-band neural oscillations and/or Beta-band neural oscillations.

Embodiments of the disclosure are drawn to implantable stimulator with machine learning based classifier. An implantable system includes sensors which provide sensor information to an implantable unit. The implantable unit uses a classifier on the sensor information to select a stimulation procedure which is applied via a stimulation electrode. The classifier may be generated by a trained machine learning model. The classifier may be trained on an external unit which is not implanted in the subject. The classifier may be trained based on sensor information from the implanted sensors as well as symptom information.

Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.

A method of localizing brain regions for the purpose of guiding placement of electrodes and related implants is disclosed. The inventive method involves effecting a pulse in a patient's brain, temporally aligning readings taken from an electrode at various depths, measuring local field potentials at each depth during interstimulus intervals, performing a coherence analysis comparing the local field potential measurements of the different depths, and determining a corresponding brain region for the depths compared.

A device for decreasing the pain associated with biopsies for cancer determination. The device includes electrical stimulation and injection of anesthetics.