A device, system, and method for facilitating a sleep cycle in a subject during a pandemic or peri COVID vaccination period, comprising determining a current awake or sleep stage of a person; automatically defining a desired sleep cycle pattern, dependent on the current awake or sleep stage of the person; generating an audio or optical stimulation pattern by an automated processor; and entraining brainwaves of the brain of the person with the stimulation pattern corresponding to the desired sleep cycle pattern, to thereby induce a sleep cycle in the person according to the sleep cycle pattern. When sleep patterns are normalized, a SARS-Cov-2 vaccination may be administered to the person.

Methods and/or devices to identify disease burden indication are disclosed. One type of disease comprises sleep disordered breathing and/or related parameters, which may be sensed via implantable sensors such as an acceleration sensor.

The present disclose generally relates to systems and methods for active titration of one or more cranial or peripheral nerve stimulators to treat obstructive sleep apnea. The active titration can be accomplished in an automated fashion by a closed-loop process. The closed-loop process can be executed by a computing device that includes a non-transitory memory storing instructions and a processor to execute the instructions to perform operations. The operations can include defining initial parameters for the one or more cranial or peripheral nerve stimulators for a patient; receiving sensor data from sensors associated with the patient based on a stimulation with the one or more cranial or peripheral stimulators programmed according to the initial parameters; and adjusting the initial parameters based on the sensor data.

Systems and techniques are disclosed to generate programming parameters and modifications during closed-loop adjustment of an implantable neurostimulation device treatment programming, through the identification and application of weights determined from user input indications and rankings of therapy objectives. In an example, a system to generate programming values of a neurostimulation device performs operations that: obtains human input which indicates multiple therapy objectives for neurostimulation treatment of a human patient; operates a model (such as an artificial intelligence model) to determine parameter outputs for programming of the neurostimulation device; identifies weights, based on the therapy objectives, usable in the model; produces a composite output from the model, by applying the identified weights to a combination of the parameter outputs of the programming model; and the resulting composite output provides neurostimulation device programming values for neurostimulation treatment designed to address the therapy objectives.

A wireless implantable neuromuscular stimulator includes an antenna for producing an induced current in response to being disposed in an electromagnetic field. The antenna includes a substrate having an upper surface and a lower surface. An upper coil including a plurality of coil turns is disposed on the upper surface of the substrate. A lower coil including a plurality of coil turns is disposed on the lower surface of the substrate. The upper and lower coils are electrically connected to each other in parallel. The parallel connection can be facilitated by a plurality of connectors that extend through the substrate and electrically connect the upper coil to the lower coil. In one example configuration, connectors connect each coil turn of the upper coil to a corresponding turn of the lower coil.

A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

Processing circuitry of a system configured to determine a patient state based on sensed signals including posture and activity information and control delivery of electrical stimulation therapy to the patient via electrodes implanted proximal to target tissue of the patient. The sensed signals also include impedance measurement, and other bioelectrical signals, where sensing is interleaved with the electrical stimulation therapy. Responsive to determining the patient state, select an action, wherein the selected action comprises one or more of: store collected information, upload the collected information to an external computing device, and output an electronic signal comprising an alert.

Processing circuitry for a medical system configured to determine posture and activity information of a patient and sense bioelectrical signals as well as receive information about the environment of the patient. The processing circuitry is configured to determine respiration activity of the patient based on the sensed signals and determine a degree of distress of the patient based on the sensed signals and the determined respiration activity. Responsive to determining the degree of distress, the processing circuitry is configured to output a command signal, which may adjust the output of stimulation circuitry configured to deliver electrical stimulation to a patient via a set of electrodes implanted proximal target tissue of the patient, upload the received information, cause the communication circuitry to send an electronic message comprising a notification of the degree of distress of the patient or take other actions.

Processing circuitry for a medical system configured to sense bioelectrical signals and determine posture and activity information as well as information about the environment of the patient. The processing circuitry is also configured to control stimulation generation circuitry to deliver the electrical stimulation therapy, and interleaved with the electrical stimulation therapy, control the stimulation generation circuitry to output an impedance measurement signal. The processing circuitry is further configured to determine respiration of the patient based on the impedance. Responsive to determining the respiration of the patient, the processing circuitry may then determine a patient state based on the determined respiration, and the posture and activity information of the patient. Based on the patient state, the processing circuitry may select an action including one or more of: store collected information, upload the collected information to an external computing device, and output an electronic signal comprising an alert.

Neuromodulation of cranial nerves can be used to treat sleep or breathing disorders, among other diseases and disorders. A neuromodulation system can include a housing configured for implantation in an anterior cervical region of a patient, such as at or under a mandible of the patient, such as at least partially in one or more of a submental triangle, a submandibular triangle, and a carotid triangle. The system can include an electrode lead coupled to the housing, and the electrode lead can include an electrode configured to be disposed at or near a cranial nerve target in the patient. The system can be configured to generate electrical neuromodulation signals for delivery to the cranial nerve target using the electrode.