A stimulation system includes an energy source, an electronics unit with a controller, and an actuator that is coupled with the electronics unit and/or the energy source. The actuator emits electromagnetic waves for stimulation of genetically manipulated tissue. The electronics unit is disposed in a housing. The stimulation system is configured for at least temporary implantation in a human or animal body. The controller controls the stimulation of tissue in the body by way of the electromagnetic waves emitted by the actuator. A selector of the stimulation system selects the area of the said tissue for stimulation. The selector includes a masking device for masking certain areas of the tissue, so that an intensity of the stimulation for the masked areas is reduced or equal to zero.

Embodiments of the instant invention relate to applying motor learning to promote remyelination following demyelination in a subject having a condition or disease. In certain embodiments, applying motor learning alone or in combination with vagus nerve stimulation (VNS) induces the production of new and preserves surviving oligodendrocytes. In accordance with certain embodiments of the disclosure, motor learning, when properly timed, enhances oligodendrogenesis after injury and recruits mature oligodendrocytes to participate in remyelination through the generation of new myelin sheaths. In other aspects of the disclosure, VNS paired with motor learning enhances remyelination following demyelination.

A neurostimulation system is shown and described. The neurostimulation system may include a stimulation device implantable into a patient, a lead operatively coupled with the stimulation device, a first power cell providing power to the stimulation device where the first power cell is charged by an externally applied AC (High HF) magnetic field.

An example of a system for delivering neurostimulation energy to a patient using a plurality of electrodes may include a stimulation circuit and a sensing circuit. The stimulation circuit may be configured to deliver the neurostimulation energy using stimulation electrodes selected from the plurality of electrodes and to control the delivery of the neurostimulation energy. The sensing circuit may be configured to receive one or more neural signals from sensing electrodes selected from the plurality of electrodes and may include a signal processing circuit. The signal processing circuit may include a detection circuit and an analysis circuit. The detection circuit may be configured to detect one or more attributes of neural responses from the received one or more neural signals. The analysis circuit may be configured to analyze the detected one or more attributes of the neural responses for one or more indications of a neurodegenerative disease.

A system and method of coupling acoustic and electrical stimulation of noninvasive neuromodulation is a therapeutic system and method preferably designed for the diagnosis and/or treatment of neurodegenerative diseases and neurological disorders including, but not limited to, tinnitus, hyperacusis, sleep disorder, depression, anxiety, dizziness, migraine, or ear suffocation. The system includes acoustic signal devices for deep brain electrical stimulation and electrical pulse devices for shallow brain electrical stimulation. Further, the system includes a signal-coupling module that includes an algorithm for coupling acoustic signals to electrical pulses. Parameters of each the acoustic signals and the electrical pulses are adjusted in order for the acoustic signals to be coupled to the electrical pulses. These parameters can also be adjusted based on patient feedback. Furthermore, the system can synchronously output the coupled acoustic signals and the coupled electrical pulses, asynchronously output the acoustic signals, or the electrical pulses based on patient feedback.

A method of stimulation treatment for medical disorders using stimulation parameters that provide stimulation of a target site directly or create partial stimulation signals that combine into vector signals that stimulate a target site. Stimulation signals have characteristics such as frequency, timing, temporal content that is adjusted for the person being treated. Signals are designed with advantageous characteristics to influence target tissue in an intended manner and avoid producing unwanted side-effects. Stimulation signals are designed to match or avoid internal/endogenous activity (e.g., brain patterns and rhythms) of a patient. Methods for choosing, creating and partial signals are provided. Tissue modulation may be accomplished with electrical and/or magnetic stimulation, such as repetitive transcranial magnetic stimulation.

A system may include a stimulator, sensing circuitry and a controller. The stimulator may be operably connected to at least one stimulation electrode, and configured to deliver an electrical waveform for an electrical therapy using the at least one stimulation electrode. The sensing circuitry may be operably connected to at least one sensing electrode, and configured to sense electrical potentials that are evoked by the electrical waveform to provide sensed evoked signals. The controller may be operably connected to the stimulator and the sensing circuitry. The controller may be configured to automatically define a sampling window, sample the sensed evoked potentials during the sampling window to provide sampled values, detect at least one feature from the sampled values, and automatically provide feedback for closed-loop control of the electrical therapy based on the at least one feature.

The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other seizure disorders and movement and other related disorders, as well as for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve.

Systems and methods for treating a cognitive disease or disorder are provided. A treatment method comprises: selecting a target volume of brain tissue to be stimulated; identifying at least one avoidance volume of brain tissue; selecting a first stimulation lead comprising at least one stimulation element; identifying at least one proposed trajectory for placement of the first stimulation lead based on the target volume and the at least one avoidance volume; placing the first stimulation lead along a placement trajectory selected from the at least one proposed trajectory; attaching the first stimulation lead to a stimulator; and stimulating the target volume with the first stimulation lead at least one stimulation element to treat at least one of a cognitive disease or a cognitive disorder. Systems include a stimulator with one or more stimulation leads and an image analyzer for identifying a proposed trajectory for placing the stimulation leads.

The types of electrode leads that are connected to an implantable medical device are determined based on electrical parameters that are measured at the electrodes that are positioned on the leads. The different types of known electrode leads have different physical electrode arrangements that impact the measured electrical parameters. Properties in the measured electrical parameters that are indicative of the physical arrangements of electrodes of known types of electrode leads are utilized to determine the types of leads that are connected to the implantable medical device.