An oral appliance for treating sleep apnea in a user includes a mouthpiece configured for being positioned in an oral cavity of the user, and at least one pulse oximeter attached to the mouthpiece. According to an aspect, the pulse oximeter is configured to monitor actual oxygen saturation levels of hemoglobin of the user when the oral appliance is positioned in the oral cavity of the user. The oral appliance may include an additional sensor attached to the mouthpiece that includes at least one of an airflow sensor, a pressure sensor, a noise detector, and an actigraphy sensor.

Systems and methods for providing a trial neurostimulation to a patient for assessing suitability of a permanently implanted neurostimulation are provided herein. In one aspect, a trial neurostimulation system includes an EPG patch adhered to a skin surface of a patient and connected to a lead extending through a percutaneous incision to a target tissue location. The EPG may be a modified version of the IPG used in the permanent system, the EPG may be smaller and/or lighter than the corresponding IPG device. The EPG and a lead extension may be sealed to allow improved patient mobility and reduced risk of infection. The EPG may be compatible with wireless systems used to control and monitor the IPG such that operation and control of the EPG is substantially the same in each system to allow seemless conversion to the permanently implanted system.

This invention relates generally to systems and methods for multifocal direct brain stimulation to enhance cognitive processing, such as but not limited to stimulation-induced modulation of memory.

The present invention relates to a closed loop computer brain interface device for an individual comprising a receiver module configured to obtain at least one sensor signal indicative of a movement or action of the individual, a processing module operably connected to the receiver module and configured to determine at least one neuronal feedback signal based at least in part on the obtained sensor signal and a transmitter module operably connected to the processing module and configured to transmit the determined neuronal feedback signal to a neurostimulation device of the individual or a neurostimulation module operably connected to the processing module, wherein the neuronal feedback signal is configured to elicit a sensory percept in the cortex of the individual via stimulating afferent sensory axons of the central nervous system targeting sensory neurons of the cortex of the individual and wherein the elicited sensory percept indicates movement support information related to the obtained sensor signal to support the execution of the movement or action of the individual.

The present invention further relates to a computer program comprising instructions for implementing a closed loop computer brain interface device when being executed by signal processing and transceiver modules of a signal and data processing device, a neuronal stimulation device or system.

Prophylactic stimulation and abortive electrical stimulation are delivered to a cranial nerve, including, e.g. an occipital or trigeminal nerve to treat symptoms of various conditions, including, e.g. occipital neuralgia or migraines.

An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to: access a patient metric of a subject; use the patient metric as an input to a machine learning algorithm, the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets, the candidate neuromodulation parameter set designed to produce a non-regular waveform that varies over a time domain and a space domain; and program a neuromodulator using the candidate neuromodulation parameter set to stimulate the subject.

Techniques are disclosed for defining a homeostatic window for controlling delivery of electrical stimulation therapy to a patient. In one example, a method includes generating and delivering electrical stimulation therapy to tissue of a patient via electrodes. Further, the method includes adjusting a level of a parameter of the electrical stimulation therapy such that a signal of the patient is not less than a lower bound and not greater than an upper bound. The lower bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce one or more symptoms of a disease while the patient was receiving medication for reduction of the one or more symptoms. Further, the upper bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce the one or more symptoms when the patient was not receiving the medication.

An embodiment in accordance with the present invention is directed to a system and device for applying electrical direct current transcranially to the brain that is combined with a behavioral activity consisting of an isometric force production task. The device is non-invasive or implantable and serves to improve motor symptoms in Parkinson's disease (PD) and other movement disorders. During the stimulation, the patient is engaged in a behavioral task using a system consisting of two force transducers and a controller. The patient holds the transducers, one in each hand, and is engaged in a task that requires the brain to assign forces to each arm so that the sum of the forces matches an instructed amount. In an electrode placement specifically for PD, bilateral primary motor cortices are simultaneously stimulated according to a specific algorithm that depends on the forces that the PD affected individual produces in the behavioral task.

Systems and methods are provided for stimulating the brain of a patient to treat a medical condition. In some aspects, a method includes positioning a stimulating device comprising electrical contacts configured to electrically stimulate locations associated with a patient's brain, and initiating a rehabilitation process to include the patient performing a task. The method also includes acquiring feedback from the patient at least while the patient is performing the task, generating, based on the acquired feedback, electrical stimulations to treat the medical condition of the patient. In some aspects, the method further includes generating a report indicative of a patient performance.

A model of an implantable lead is provided via a graphical user interface. The implantable lead is configured to deliver electrical stimulation to a patient via a plurality of electrodes located on the implantable lead. The graphical user interface also provides a plurality of predefined electrode activation patterns that include a coarse pattern and a refined pattern. The coarse pattern corresponds to a first group of electrodes located in a first region of the implantable lead. The refined pattern corresponds to a second group of electrodes located in a second region of the implantable lead. The second region is smaller than, and is a subsection of, the first region. A coarse testing process is performed by selectively activating the first group of electrodes belonging to the coarse pattern. Thereafter, a refined testing process is performed by selectively activating the second group of electrodes belonging to the refined pattern.