A method includes receiving, with one or more processors, a first ambulatory velocity information of a patient while electrical stimulation with a first set of stimulation parameters is being delivered to the patient; adjusting, based on the first ambulatory velocity information and by a predetermined amount, one or more of the first set of stimulation parameters to generate an adjusted set of stimulation parameters by a predetermined amount; receiving, with the one or more processors, a subsequent ambulatory velocity information of the patient while the electrical stimulation with an adjusted set of stimulation parameters is being delivered to the patient; and generating, with the one or more processors and based on the subsequent ambulatory velocity, one or more recommended electrical stimulation parameters the patient.

A stimulation system includes a device programmed with user-specified routines for operation of a pulse generator, where the user-specified routines are activatable in response to information received from a source external to the pulse generator, The device includes a memory, a communication unit, and at least one processor coupled to the memory and the communication unit and configured to perform actions, including receiving, using the communication unit, information provided from the source external to the pulse generator and external to the patient, when the information meets an activation criterion for a one of the user-specified routines, activating the user-specified routine to deliver or halt delivery of stimulation to the patient according to the user-specified routine, and upon completion of the user-specified routine or meeting a termination condition, halting the user-specified routine.

A computer implemented method is provided that includes, under control of one or more processors of an implantable medical device (IMD), obtaining motion data indicative of a first posture, and determining a first sense setting of the IMD based on the first posture. The method also includes obtaining cardiac activity (CA) signals for a series of beats while applying the first sense setting, obtaining a characteristic of interest (COI) from the CA signals for the series of beats, and calculating a statistical indicator from the COI over the series of beats based on the COI from the CA signals. The method also includes deriving a second sense setting based on the first sense setting and the statistical indicator of the COI.

Embodiments of the present disclosure include a method for acquiring, with a device, a plurality of electrical signals from a brain of a subject, and determining whether a biomarker is present in the plurality of electrical signals. The biomarker comprises at least one phase metric associated with the electrical signal, and further includes adjusting at least one therapy parameter based on biomarker assessment.

Modulation of neural signaling of a pancreas-related sympathetic nerve is capable of improving glycaemic control by inhibiting T cell activation or migration to the pancreas, and hence providing a way of treating or preventing type 1 diabetes.

An example of a system for delivering neurostimulation may include a programming control circuit and a stimulation control circuit. The programming control circuit may be configured to generate stimulation parameters controlling delivery of the neurostimulation according to a stimulation configuration. The stimulation control circuit may be configured to specify the stimulation configuration, and may include volume definition circuitry and stimulation configuration circuitry. The volume definition circuitry may be configured to determine one or more test volumes, determine a clinical effect resulting from the one or more test volumes each being activated by the neurostimulation, and determine a target volume using the determined clinical effect. The stimulation configuration circuitry may be configured to generate the specified stimulation configuration for activating the target volume.

The invention provides systems and methods for monitoring electrical biosignals of one or more biological cells, tissues, and/or organs of a patient and assessing a condition of the patient based on the electrical biosignals.

Systems and method may be used for interfacing with a patient. Systems may include a plurality of electrodes in electrical communication with a processor. The processor may be configured to receive sense signals from electrodes and to determine the reliability of the received signal. A test tone signal comprising a test tone frequency may be applied, and the magnitude of the test tone frequency may be analyzed in the received signal. If it is determined that the magnitude of the test tone frequency is below a threshold, the system may take action, such as lowering the gain on an amplifier. Stimulation signals may be applied to the patient at a stimulation frequency simultaneously with one or both of receiving sense signals and providing the test tone signal.

The present invention relates to systems and methods for planning and/or providing neuromodulation. An example system includes a first data input module for stimulation related basic data, a second data input module for stimulation related response data, a transfer module configured and arranged such that the stimulation related basic data received by the data input module are linked and/or translated into and/or with the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, and a mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, which describes an interrelation between the stimulation related basic data and the stimulation related response data and the transfer data.

An example of a neurostimulation system may include a stimulation output circuit to deliver the neurostimulation, a sensing circuit to sense a signal indicative of a response to the neurostimulation, and a stimulation control circuit to control the delivery of the neurostimulation using stimulation parameters. The stimulation control circuit may include a response detector and a steering module. The response detector may be configured to detect signal feature(s) from the sensed signal and to determine a response parameter indicative of an intensity of the response to the neurostimulation using the detected signal feature(s). The steering module may be configured to receive user commands for moving a stimulation field and to adjust the stimulation parameters to move the stimulation field according to the user commands while maintaining a value of the response parameter between thresholds.