The present disclosure relates generally to using detected bladder events for the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction. A system includes a sensing device comprising a pressure sensor to directly detect a pressure within a bladder. The sensing device is adapted to be located within the bladder. The system also includes a signal processing device to: receive a signal indicating the detected pressure within the bladder; detect a bladder event based the detected pressure within the signal; and characterize the bladder event as a bladder contraction event or a non-contraction event. The characterization of the bladder event can be used in the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction.

A method for selective activation of central thalamus fibers in a subject is disclosed. The method involves providing one or more electrodes each with one or more contacts. The one or more electrodes are positioned in the subject’s central thalamus fibers. An electrical stimulus is applied to the positioned one or more electrodes to selectively activate the central thalamus fibers of the subject. The positioning and applying are carried out to maximize central lateral nucleus and medial dorsal tegmental tract fiber pathway activation in the subject and to minimize central median parafascicularis fiber pathway activation in the subject. Methods, devices, and computer readable media for surgical planning involving selective activation of central thalamus fibers in a subject are also disclosed.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and/or avoid unwanted side effects.

In Spinal Cord Stimulation (SCS) systems having sensing capability, conventional wisdom seeks to minimize or avoid sensing of stimulation artifacts caused by the stimulation. Despite this, the present disclosure recognizes that stimulation artifacts in and of itself can include useful information relevant to operation of the SCS implant and/or the status of the patient. In particular, stimulation artifact features as sensed canbe used to determine a posture or activity of the patient, or more generally to adjust the stimulation program that the SCS implant is providing. Furthermore, sensing of stimulation artifact features can be as useful as, and possibly even more useful than, information gleaned from sensing neural responses to stimulation, such as Evoked Compound Action Potentials (ECAPs).

This document discusses a computer-implemented method of machine recognition of a physiological condition of a subject. The computer-implemented method comprises obtaining a video stream of the subject using a video data source; identifying, using processing circuitry, one or more areas within image frames of the video stream that contain a physiological feature of the subject; analyzing video data of the identified one or more areas in the image frames using the processing circuitry to detect change of the physiological feature between a first frame of video data and a later frame of video data; determining one or more change parameters of the physiological feature from the video data; and generating an indication of a symptom of Parkinson's Disease according to a detection criterion applied to the one or more change parameters.

The present disclosure provides systems and methods for providing neurostimulation therapy using multi-dimensional patient features. The multi-dimensional patient features may include features in respective frequency bands for selected cortical sites from EEG localization data. Additionally or alternatively, the multi-dimensional patient features may include features from patient physiological data or other patient activity data. The multi-dimensional feature data may be compared against AI/ML models of patient and/or healthy population members. Closed-loop therapy adjustments may be applied to a respective patient’s neurostimulation therapy using the multi-dimensional patient feature analysis.

A method for inducing a hibernation-like state and a device for the same is described. The method is a chemical and physical method for reducing, in a subject, a theoretical set-point temperature of a body temperature and/or a feedback gain of heat production, or for inducing a hibernation-like state in the subject, the method including applying an excitatory stimulus to pyroglutamylated RFamide peptide (QRFP)-producing neurons. A device used to implement the method is also described.

An assistance method for assisting a person in grasping or otherwise manipulating an object includes receiving video of a hand of the person and of an object. An intent to grasp the object is identified based on proximity of the hand to the object in the video or as measured by a proximity sensor, or using gaze tracking, or based on measured neural activity of the person. The object and the hand in the video are analyzed to determine an object grasping action for grasping or otherwise manipulating the object. An actuator is controlled to cause the hand to perform the determined hand action for grasping or otherwise manipulating the object.

Described herein are methods, devices and systems for efficiently storing data for sensed biological signals. A sensed biological signal, or an amplitude and/or filtered version thereof, is provided to an N-bit ADC of an IMD to produce an N-bit data value indicative of an amplitude of the biological signal at a point in time. One of a plurality of chords of a compression curve is selected, based on a magnitude of the N-bit data value, and used to produce an M-bit data value, which is a compressed version of the N-bit data value, wherein M<N. The M-bit data value is stored as an M-bit data slice within memory of the IMD, and can be expanded to a reproduced N-bit data value after being uploaded to a non-implanted device or system.

A patient external controller is provided for controlling sub-perception stimulation provided by a patients implantable stimulator device having an electrode array. Control circuitry in the controller renders a graphical user interface (GUI), including a location at which the sub-perception stimulation is provided within the electrode array, and a pre-defined region in which the location can be moved. The pre-defined region may be constrained to less than the entire electrode array. The control circuitry receives one or more first inputs to move the location of the sub-perception stimulation within the region and to program the stimulator to move the sub-perception stimulation to the moved location in the electrode array. The control circuitry can enable adjustment of an amplitude of the sub-perception stimulation to a value that is less than or equal to a perception threshold. Once moved, the sub-perception stimulation an be stored as a second stimulation program.