A method for automating selection of stimulation parameters for a stimulation device implanted in a patient includes setting, by a user, at least one limit on each of at least one stimulation parameter and performing, automatically using at least one processor, the following actions for each of a plurality of sets of the stimulation parameters constrained by the at least one limit: stimulating the patient, by the stimulation device, using the set of stimulation parameters, sensing one or more effects arising in response to the stimulation, and updating, by the at least one processor, a collection of the effects and sets of stimulation parameters with the one or more effects and the set of stimulation parameters. The method further includes selecting, by the processor, one of the sets of stimulation parameters based on the effects.

An implantable neurostimulator for delivering one or more stimulation pulses to a target region within a patient's body. The implantable neurostimulator including a housing and an energy storage feature. There is also a lead coupled to the hermetic housing and a plurality of electrodes located proximate to a distal end of the lead. The neurostimulator includes stimulation circuitry that includes an adjustable resistance element. A voltage of the electric signal derived from the energy storage feature and a resistance of the adjustable resistance element are both adjusted based on a measurement of a value indicative of a tissue impedance of the target region to provide a desired value of a stimulation current for the one or more stimulation pulses.

Aspects of this disclosure describe methods and systems for nerve stimulation using a balloon catheter. The balloon catheter includes a catheter, an inflatable balloon with a surface, and a set of electrodes positioned along the surface of the inflatable balloon. The balloon catheter may be positioned in a vessel of a patient, such as the esophagus. The patient may be concurrently undergoing mechanical ventilation. The balloon catheter is secured in the vessel by inflating the inflatable balloon. When the inflatable balloon is inflated, the surface of the inflatable balloon and the set of electrodes is positioned at an internal wall of the vessel. Stimulation is provided to a nerve near the vessel, via the set of electrodes, based on stimulation parameters. Values for the stimulation parameters may be adjusted based on breathing parameters of the patient. The stimulation parameters may also be adjusted to wean a patient off mechanical ventilation.

A method comprising detecting an epileptic event in a patient; applying an electrical therapy to a first target area in at least one of a brain region or a cranial nerve of said patient in response to said detecting; receiving a body signal responsive to the electrical therapy, wherein said body signal is selected from an autonomic signal, a neurologic signal, a metabolic signal, an endocrine signal, or a tissue stress marker signal; determining whether said body signal indicates that said electrical therapy has an efficacious effect; and terminating the application of said electrical therapy if the response indicates that the electrical therapy has an efficacious effect. An apparatus capable of performing the method. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform the method.

An implant unit configured for implantation into a body of a subject is provided. The implant unit may include a flexible carrier unit including a central portion and two elongated arms extending from the central portion, an antenna, located on the central portion, configured to receive a signal, at least one pair of electrodes arranged on a first elongated arm of the two elongated arms. The at least one pair of electrodes may be adapted to modulate a first nerve. The elongated arms of the flexible carrier may be configured to form an open ended curvature around a muscle with the nerve to be stimulated within an arc of the curvature.

Graphical User Interface (GUI) control of a stimulator device is disclosed. The GUI receives modeling information indicating optimal stimulation parameters for a patient based on patient testing, and may also receive an indication of a particular stimulation mode to be used for the patient which comprises a subset of those parameters. The GUI provides simple options to allow a user to navigate the optimal parameters or subsets to constrain selection to only those stimulation parameters set within the optimal parameters or subsets.

Articles and methods for non-invasively treating peripheral neuropathy via transcutaneous electrical stimulation of target nerve tissue are described. An exemplary article includes a support on which an electrode pair is positioned; a controller attached to the electrode pair via one or more leads; and a power supply connected to the controller. The article delivers electrical stimulation to the target nerve tissue via the electrode pair at a level sufficient to initiate vasodilation of vasculature within or adjacent the tissue. Meanwhile, the method includes positioning at least one electrode pair adjacent an area of skin overlying or in close proximity to the target nerve tissue and delivering electrical stimulation to the tissue via the electrode pair. The electrical stimulation is delivered at a level sufficient to initiate vasodilation of vasculature within or adjacent the tissue. An implantable system and method for treating peripheral neuropathy via percutaneous electrical stimulation are also described.

An example of a system may include a processor; and a memory device comprising instructions, which when executed by the processor, cause the processor to access at least one of: patient input, clinician input, or automatic input; use the patient input, clinician input, or automatic input in a search method, the search method designed to evaluate a plurality of candidate neuromodulation parameter sets to identify an optimal neuromodulation parameter set; and program a neuromodulator using the optimal neuromodulation parameter set to stimulate a patient.

A cochlear implant is disclosed. The cochlear implant provides electrical stimulation to auditory nerve fibers of a cochlea of a recipient of the cochlear implant. The cochlear implant includes an interface to provide audio stimulation information based on an external signal, an electrode lead including a plurality of electrodes to provide electrical stimulation the auditory nerve fibers based on the audio stimulation information, a differential power supplier to provide an anodic current and a cathodic current based on the audio stimulation information, and a mode unit connected to one or more electrodes of the plurality of electrodes. The mode unit sets the one or more electrodes into a mode of a plurality of modes based on the audio stimulation information. The plurality of modes includes an active mode, and in the active mode the one or more electrodes receives the anodic current or the cathodic current.

The present disclosure provides systems and methods for providing neurostimulation therapy using multi-dimensional patient features. The multi-dimensional patient features may include features in respective frequency bands for selected cortical sites from EEG localization data. Additionally or alternatively, the multi-dimensional patient features may include features from patient physiological data or other patient activity data. The multi-dimensional feature data may be compared against AI/ML models of patient and/or healthy population members. Closed-loop therapy adjustments may be applied to a respective patient’s neurostimulation therapy using the multi-dimensional patient feature analysis.