A method, comprising receiving at least one of a signal relating to a first cardiac activity and a signal relating to a first body movement from a patient; triggering at least one of a test of the patient's responsiveness, awareness, a second cardiac activity, a second body movement, a spectral analysis test of the second cardiac activity, and a spectral analysis test of the second body movement, based on at least one of the signal relating to the first cardiac activity and the signal relating to the first body movement; determining an occurrence of an epileptic event based at least in part on said one or more triggered tests; and performing a further action in response to said determination of said occurrence of said epileptic event. Further methods allow classification of epileptic events. Apparatus and systems capable of implementing the method.

An implantable medical device for stimulating a human or animal heart. In operation, the device performs the following steps: a) sensing an atrial electric signal a the first detection unit; b) sensing an electric signal at the His bundle with a second detection unit upon termination of a first time period starting upon sensing the atrial electric signal with the first detection unit and/or starting upon applying a stimulation pulse, wherein the first time period lies in a range of from 10 ms to 100 ms; c) classifying the electric signal sensed with the second detection unit as His bundle activity signal or as ventricular activity signal.

Systems and methods are described for subject rehospitalization management. In an example, multiple physiologic signals can be obtained from a subject using multiple sensors. In response to a hospitalization event, pre-hospitalization characteristics of the multiple physiologic signals can be identified. Post-hospitalization characteristics of the multiple physiologic signals can be identified, including characteristics that differ from their corresponding pre-hospitalization characteristics. Later subsequent physiologic signals can be further monitored after the hospitalization event, such as using the same multiple sensors, and subsequent physiologic signal characteristics can be identified. In an example, a heart failure diagnostic indication can be determined using information about the pre-hospitalization characteristics, the post-hospitalization characteristics, and the subsequent characteristics. Information about relative changes in signal characteristics from multiple sensors can be used to identify particular subject physiologic signals to monitor during subsequent periods.

A cardiac pacing system having a pulse generator for generating therapeutic electric pulses, a lead electrically coupled with the pulse generator having an electrode, a first sensor configured to monitor a physiological characteristic of a patient, a second sensor configured to monitor a second physiological characteristic of a patient and a controller. The controller can determine a pacing vector based on variables including a signal received from the second sensor, and cause the pulse generator to deliver the therapeutic electrical pulses according to the determined pacing vector. The controller can also modify pacing characteristics based on variables including a signal received from the second sensor.

A cardiac pacing system having a pulse generator for generating therapeutic electric pulses, a lead electrically coupled with the pulse generator having an electrode, a first sensor configured to monitor a physiological characteristic of a patient, a second sensor configured to monitor a second physiological characteristic of a patient and a controller. The controller can determine a pacing vector based on variables including a signal received from the second sensor, and cause the pulse generator to deliver the therapeutic electrical pulses according to the determined pacing vector. The controller can also modify pacing characteristics based on variables including a signal received from the second sensor.

An implantable medical device for stimulating a human or animal heart, comprising a first processor, a first memory unit, a stimulation unit configured to stimulate a first cardiac region of a human or animal heart, and a detection unit configured to detect an electric signal at the first cardiac region of the same heart, wherein the detection unit comprises i) an electrode lead having an electrode pole and ii) a first channel for measuring electric signals provided by the electrode lead. A maximum sensitivity of the first channel of the detection unit is adjustable in dependence on a stimulation site of the electrode pole, wherein the maximum sensitivity of the first channel lies in a range of from 0.1 mV to 0.4 mV if the electrode pole is intended to detect electric signals at the His bundle of the heart.

A programming device for programming an implantable medical device for stimulating a human or animal heart, wherein the following steps are performed: a) allowing to select one of at least two electrode lead configurations for stimulating a human or animal heart, wherein the at least two electrode lead configurations comprise a second electrode lead configuration in which at least one electrode lead is connected to an electrode lead port, the electrode lead port being configured to receive an electrode lead for stimulating a second cardiac region or detecting an electric signal at the second cardiac region, wherein the second cardiac region is a part of a ventricular conduction system of the heart, wherein the at least one electrode lead is intended to be implanted or is implanted in the second cardiac region; b) generating and releasing a notification signal if the second electrode lead configuration is selected.

A cardiac pacing system having a pulse generator for generating therapeutic electric pulses, a lead electrically coupled with the pulse generator having an electrode, a first sensor configured to monitor a physiological characteristic of a patient, a second sensor configured to monitor a second physiological characteristic of a patient and a controller. The controller can determine a pacing vector based on variables including a signal received from the second sensor, and cause the pulse generator to deliver the therapeutic electrical pulses according to the determined pacing vector. The controller can also modify pacing characteristics based on variables including a signal received from the second sensor.

An implantable medical device for stimulating a human or animal heart. In operation, the device performs the following steps: a) sensing an atrial electric signal a the first detection unit; b) sensing an electric signal at the His bundle with a second detection unit upon termination of a first time period starting upon sensing the atrial electric signal with the first detection unit and/or starting upon applying a stimulation pulse, wherein the first time period lies in a range of from 10 ms to 100 ms; c) classifying the electric signal sensed with the second detection unit as His bundle activity signal or as ventricular activity signal.

An implantable medical device for stimulating a human/animal heart, comprising a first electrode lead port for receiving an electrode lead. The first electrode lead port comprises a first marking element and a second marking element, wherein the first marking element indicates a first kind of electrode lead that can be received by the first electrode lead port and for an operation of which the first electrode lead port is designed to be configured, wherein the first kind of electrode lead is a His bundle electrode lead , wherein the second marking element indicates a second kind of electrode lead that can be received by the first electrode lead port and for an operation of which the first electrode lead port is designed to be configured. The second kind of electrode lead includes one of an atrial electrode lead, a right ventricular electrode lead, and a left ventricular electrode lead.