Systems including intra-calvarial implants and/or subdermal implants are capable of stimulating cortical regions and sensing and electrical signals is implanted within or on a calvarial bone of a skull. The implants have current steering capability to change the current density profiles applied to selected cortical regions underlying the implant. The systems may track changes in the position and/or spatial parameters of a neural network by recording cortical electrical signals and processing them to compute the values of one or more network activity biomarkers. The systems may spatially track changes detected in network anatomical position and deliver the stimulation of the cortex to the network detected position by using current steering methods.

Provided are methods of making a liquid and liquid vapor-proof material, and relates long-term implantable electronic devices. The method comprisies providing a first substrate having a first-side encapsulating layer supported by at least a portion of the first substrate; providing a material onto the first-side encapsulating layer; providing a second substrate having a second-side encapsulating layer supported by at least a portion of the second substrate; covering an exposed surface of the material provided onto the first-side encapsulation layer with the second-side encapsulating layer; wherein said encapsulating layers are substantially defect free so that liquid or liquid vapor is prevented from passing through each of the encapsulating layers; thereby making the liquid or liquid vapor-proof material.

An implantable device and method of manufacture include a substantially hermetic polychlorotrifluoroethylene (PCTFE) enclosure with closely-spaced wires extending out of the enclosure. The implantable device includes a PCTFE first portion of an enclosure and a PCTFE second portion of the enclosure. The first and second portions are configured to mate with each other to form the enclosure. A plurality of insulated wires extend between the first and second portions of the enclosure. Each of the insulated wires are parallel to each other and separated by less than 150 micrometers (μm) from a neighboring wire. A thermal weld seam of PCTFE is disposed between the first portion of the enclosure and the second portion of the enclosure and conformally adheres around insulation of each wire such that the enclosure is sealed.

An implantable neurostimulator system is disclosed, the neurostimulator system comprising a hollow cylindrical electronics enclosure having a top, a bottom, and a side; a coil extending from a first part of the electronics enclosure; and at least one electrode operatively connected to the electronics enclosure.

A device for implant in a hole in cranium relative to a bone table includes a can having an electrical-contact pad. The can has a perimeter edge defining a boundary, and a recessed portion with an upper surface positioned to lie beneath the bone table when the can is placed in the hole. The device also include a cover assembly that couples to and decouples from the can at the electrical-contact pad. A strain relief system includes a lower strain relief and an upper strain relief. The lower strain relief defines channels that receive a portion of a lead and includes a curved portion that extends upward from the upper surface of the recessed portion to the bone table, and a linear portion that extends from the curved portion to an end beyond the perimeter edge. The upper strain relief couples to and decouples from the can and/or the lower strain relief.

A method for subcutaneously treating pain in a patient includes first providing a neurostimulator with an IPG body and at least a primary, a secondary, and a tertiary integral lead with electrodes disposed thereon. A primary incision is opened to expose the subcutaneous region below the dermis in a selected portion of the body. A pocket is then opened for the IPG through the primary incision and the integral leads are inserted through the primary incision and routed subcutaneously to desired nerve regions along desired paths. The IPG is disposed in the pocket through the primary incision. The primary incision is then closed and the IPG and the electrodes activated to provide localized stimulation to the desired nerve regions and at least three of the nerves associated therewith to achieve a desired pain reduction response from the patient.

Lead fixation devices for mounting at a cranial burr hole and securing a medical lead implanted into a brain through the burr hole. One embodiment comprises a clamp having centrally disposed clamping walls activated by a plunger having actuating tabs. The clamping walls may be an integral part of a device base, or a separate part seated in a central opening of the base. The clamp is activated by pressing the actuating tabs of the plunger into apertures adjoining the clamping walls, which displaces the clamping walls to clamp the lead. Another embodiment comprises a base having a plurality of radial and peripheral lead retention grooves configured to securely retain a substantial segment of the lead at the exit from the burr hole. Still another embodiment comprises both a clamp and peripheral retention grooves to provide a dual fixation and strain relief of the lead within the lead fixation device.

A set of shielded coils for wireless power transmission into a medical implant is described in which the external, power transmission coil is blocked at least on one side by a shield with a broken ring and radial fingers while the power receiver coil inside the medical implant is surrounded by a shield having a broken ring connecting radial fingers and ribs around its circumference. The finger and rib configurations minimizes eddy currents in the shields. A ground plane of the implant's internal circuitry, which is within the shield along with the receiver coil, can cap off the cupped receiver shield to form a Faraday cage with it. The metal or other conductive shielding prevents large electric fields from the coils from penetrating into the tissue of the subject while simultaneously allowing magnetic fields inductively couple the coils for charging. An implant with sensitive electrodes that measure minute voltages from a brain or other tissues is protected from capacitively driven voltage swings or other transients during charging.

Systems, apparatus, and methods for treating medication refractory epilepsy are disclosed. In one embodiment, a method of treating epilepsy is disclosed comprising detecting, using a first electrode array coupled to a first endovascular carrier, an electrophysiological signal of a subject. The method further comprises analyzing the electrophysiological signal using a neuromodulation unit electrically coupled to the first electrode array and stimulating an intracorporeal target of the subject using a second electrode array coupled to a second endovascular carrier implanted within a part of a bodily vessel superior to a base of the skull of the subject.

Neural stimulator systems with an external magnetic coil to produce changing magnetic fields is applied outside the body, in conjunction with one or more tiny injectable objects that concentrates the induced electric or magnetic field to a highly-targeted location. These systems include a driver circuit for the magnetic coil that allows for high voltage and fast pulses in the coil, while requiring low-voltage power supply that may be powered by a wearable or portable external device, along with the coil and driver circuit.