The present invention provides materials and methods for using electrical stimulation to treat a mammal having a proteinopathy (e.g., neurodegenerative diseases) or at risk of developing a proteinopathy are provided. For example, the present invention provides materials and methods for modulating glymphatic clearance (e.g., enhancing glymphatic clearance) of pathogenic proteins.

An endovascular device includes a thin film polymer strip having an electrode array. The thin film polymer strip includes a thin film polymer shaped into a strip having a distal end and a proximal end and a plurality of exposed metal electrodes positioned at the distal end of the thin film polymer. Each metal electrode is composed of a metal film. The thin film polymer strip also includes a plurality of bond pads positioned at the proximal end of the thin film polymer. A plurality of insulated traces connect each electrode to a single bond pad. The thin film polymer strip also includes insulated micro-wires connected to bond pads and recording or stimulation equipment. Characteristically, the thin film polymer strip has a helical or cylindrical shape configured to fit around a commercial vascular guide wire.

The present disclosure relates to a medical device, methods of making a medical device, and methods of delivering medical device. Particularly, aspects of the present disclosure are directed to a medical device having a self-expanding stent and a thin-film neural interface. The stent comprises a plurality of struts having a substantially elliptical or circular geometry arranged in series from a proximal end to a distal end of the stent, and a thin-film neural interface attached to the stent. Each strut of the self-expanding stent comprises a top portion and a base portion integrally connected with the top portion at a first connection point and a second connection point such that the top portion moves relative to the base portion. The self-expanding stent provides a retracted configuration to protect the thin-film neural interface during delivery, and an expanded configuration to deploy the thin-film neural interface.

An implant sized and shaped to be endovascularly delivered to the middle meningeal artery includes a carrier that carries a payload between first and second ends thereof. An anchor mechanism associated with the implant transitions into a swollen state in response to exposure to bodily fluids. In the swollen state, said anchor mechanism anchors the implant to the middle meningeal artery. Before or during the transition, the anchor mechanism permits endovascular delivery of the implant to the middle meningeal artery.

A fixation device configured to anchor an implantable medical device within a patient includes a temporary biodegradable fixation mechanism configured to secure the device after implantation until the temporary fixation mechanism biodegrades and a chronic fixation mechanism configured to promote tissue growth that secures the device to tissue of the patient before the temporary fixation mechanism biodegrades.

A device implantable on a target of interest of a subject for pacemaker, neuromodulator, and/or defibrillator therapy comprises a wireless power harvesting unit configured to deliver power via resonant inductive coupling to the target tissue for stimulation in a manner that eliminates need for batteries and allows for externalized control without transcutaneous leads. The device relies exclusively on materials that resorb when exposed to biofluids in a time-controlled manner via metabolic action and hydrolysis. The materials and design choices create a thin, flexible, and lightweight form that maintain excellent biocompatibility and stable function throughout a desired period of use. Over a subsequent timeframe following the completion of therapy, the devices disappear completely through natural biological processes. These characteristics and a miniaturized geometry facilitate full implantation into the body to eliminate the need for percutaneous hardware, which thereby minimizes the risk of device-associated infections and dislodgement.

A cardiac pacing system and a pacemaker fixation device are disclosed. The pacemaker fixation device includes a ring-shaped stent and at least one contractible member. The ring-shaped stent is configured to load a leadless pacemaker and easily fix it at a target site in a patient's body reliably without dislodgement. A connecting element in the contractible member can be reliably connected to an external mechanism, thus facilitating retrieval and removal of the cardiac pacing system with an increased success rate. During implantation, the contractible member can be adapted by operating the external mechanism to adjust the pacing location for the leadless pacemaker, thus allowing the operator to easily determine the best pacing location that can result in enhanced pacing performance of the leadless pacemaker. Further, the leadless pacemaker may be fixed in the atrium in order to pace the atrium, thus reducing non-physiological pacing with atrioventricular desynchronization.

The present invention provides materials and methods for using electrical stimulation to treat a mammal having a proteinopathy (e.g., neurodegenerative diseases) or at risk of developing a proteinopathy are provided. For example, the present invention provides materials and methods for modulating glymphatic clearance (e.g., enhancing glymphatic clearance) of pathogenic proteins.

An implantable medical electrical lead includes a lead body having a longitudinal axis, the lead body including proximal and distal portions, the proximal portion being generally straight, and the distal portion being formed with a helix having a central axis; and a plurality of electrodes arranged along the helix, each of the electrodes having a length parallel to a lead body portion on which each of the electrodes is disposed, where the longitudinal axis and the central axis are approximately coaxial. The helix is formed with a predetermined bias, and may include at least two coils with electrodes, and optionally a third coil to provide a stabilization function. A method for implanting the lead includes inserting the lead in a lumen, and positioning the lead to dispose the plurality of electrodes against an internal wall of the lumen, in order to stimulate an adjacent structure, such as the phrenic nerve.

An implantable leadless pacing device and delivery system may comprise an implantable leadless pacing device and a catheter configured to deliver the implantable leadless packing device to a target location. The implantable device may comprise a power source, circuitry operatively coupled to the power source, a housing at least partially enclosing the circuitry, a first electrode secured relative to and offset from a longitudinal axis of the housing and exposed exterior to the housing, and a fixation mechanism secured relative to the housing. The fixation mechanism may comprise at least one tine configured to move between an elongated delivery configuration and a curved deployed configuration and radially offset from the first electrode. The catheter may comprise a distal holding section defining a cavity configured to receive the implantable leadless pacing device.