A goggle system is provided. The goggle system includes a computing device, a goggle device configured to be worn by a user and including a detector configured to simultaneously acquire image data of a subject in a first image mode and a second image mode, at least one eye assembly configured to display at least one of an image in the first image mode, an image in the second image mode, and a hybrid image including pixels of image data from the first image mode and pixels of image data from the second image mode, and a communications module configured to transmit acquired image data from the goggle device to the computing device.

The invention relates to amphiphilic dye-coated inorganic nanoparticle clusters and uses thereof. Specifically, the invention relates to cyanine and/or cyclic tetrapyrrole dye-coated metallic nanoparticle clusters for use in medical imaging and treatments.

The present invention describes a receptor-targeting conjugate comprising a fluorophore; a molecule, e.g. a peptide, binding to the receptor; and —a linker group which covalently links the fluorophore to the molecule binding to the receptor, wherein the conjugate is adapted to be administered intravenously into a human or animal body, and provide an effective pharmacokinetic profile with reference to inter alia receptor binding affinity and removal from plasma.

The control unit includes, as a mechanical configuration, an image processing unit and a recording control unit. The image processing unit includes a combining unit that combines the fluorescence image acquired by the illuminating/photographing unit and the visible light image, a condition designation unit that designates an analysis condition and the like of an image analysis by an analyzing unit to be described later, and an analyzing unit that performs an analysis under the analysis condition designated by the condition designation unit. The storage unit includes an image storage unit including a reproduction moving image storage unit that stores a combined moving image obtained by combining the fluorescence image and the visible light image by the combining unit in the image processing unit as an irreversibly-compressed moving image file and an analysis moving image storage unit that stores a fluorescence moving image and a visible light moving image.

Extracellular vesicles isolated from blood plasma of oncological patients for selectively delivering therapeutic or diagnostic drugs are provided. Methods for isolating extracellular vesicles from an isolated sample of blood plasma and for preparing an isolated sample of blood plasma from oncological patients are also provided.

A biothiol-activatable composition is disclosed that is configured to dissociate in the presence of a concentration of biomolecules that are excreted normally by a liver of a living subject comprising a noble metal nanoparticle, a reporter molecule, a linker molecule that is conjugated to the noble metal nanoparticle and to the reporter molecule, but displaceable in the presence of the biomolecules, and wherein the reporter molecule is released in the presence of the biomolecules. The noble nanoparticle is preferably a gold nanoparticle; the reporter molecule preferably comprises at least one of a fluorescent dye molecule, a radioactive molecule or an MRI agent and the linker molecule is preferably a thiol molecule displaceable by biothiols in the liver. In another aspect, the reporter molecule dissociates from the composition in the presence of a concentration of glutathione similar to what is found in liver sinusoids of a normally functioning liver.

A method of visualizing tissue of a subject includes receiving a fluorescence image of the tissue of the subject, wherein the fluorescence image comprises a plurality of intensity values, a first portion of the intensity values are associated with a first fluorescence emission that is from fluorescence agent that is preferentially accumulated or activated in a target region in the tissue and a second portion of the intensity values are associated with a second fluorescence emission that is from fluorescence agent that is not located within the target region in the tissue; generating an enhanced fluorescence image by reducing one or more of the intensity values that are below a threshold intensity value to increase contrast between the target region in the tissue and areas that are associated with the fluorescence agent that is not located within the target region in the tissue; and displaying the enhanced fluorescence image.

A method for early stage pathology detection, location, imaging, evaluation, and treatment of cells and/or extracellular vesicles in the circulation.

A goggle system is provided. The goggle system includes a computing device, a goggle device configured to be worn by a user and including a detector configured to simultaneously acquire image data of a subject in a first image mode and a second image mode, at least one eye assembly configured to display at least one of an image in the first image mode, an image in the second image mode, and a hybrid image including pixels of image data from the first image mode and pixels of image data from the second image mode, and a communications module configured to transmit acquired image data from the goggle device to the computing device.

A method to visualize, display, analyze and quantify angiography, perfusion, and the change in angiography and perfusion in real time, is provided. This method captures image data sequences from indocyanine green near infra-red fluorescence imaging used in a variety of surgical procedure applications, where angiography and perfusion are critical for intraoperative decisions.