The present invention relates to a medicament delivery device (10) comprising a housing (12, 14); a medicament container holder (90), arranged movable in relation to said housing (12, 14) and capable of accommodating a medicament container (92); an biased activator (160) comprising a plunger rod (164), which plunger rod (164) is arranged to act on the medicament container (92) for delivering a dose of medicament through a medicament delivery member (102 when said biased activator (160) is operated; a manually operable dose setting member (72) operably connected to both said housing and said medicament container holder such that manual operation of said dose setting member (72) will cause the medicament container holder (90) with the medicament container (92) to move towards said plunger rod (164) for setting a dose of medicament to be delivered; a dose drum (56) releasably connected to the dose setting member (72) through a releasable connection mechanism (68, 84I) such that when the dose setting member is operated, said dose drum (56) is displaced from an initial position to a set dose position; a release mechanism (116) operably connected to said biased activator (160), wherein, when said plunger rod (164) is moved to an end position of the dose delivery operation, said release mechanism (116) is arranged to act on said connection mechanism (68, 84I) for releasing said dose drum (56) from said dose setting member (72). The invention is characterised in that said release mechanism is arranged with a locking mechanism (130, 84II) arranged to lock said dose setting member (72) from displacement as the connection mechanism (68, 84I) is operated for releasing said dose drum (56) from said dose setting member (72).

The invention provides an adaptor for a medicament delivery device is configured to enable a set dosage of a medicament to be drawn into and/or expelled from the device, the adaptor including: a body configured to be coupled to the device; an attachment portion movable with respect to the body and configured for attachment with a first part of the device; an engaging portion movable with the attachment portion; and a receiver configured to receive a movement constraint guide (MCG) and facilitate engagement between the engaging portion and the MCG; wherein the MCG includes one or more physical features defining at least an aspect of the set dosage; and wherein activation of said first part of the device to draw and/or expel the medicament is stopped when the set dosage is reached by engagement between the engaging portion and at least one of the one or more physical features of the MCG. The invention thus allows ready control of one or more aspects of dosage administration, which can be the amount of a dose and/or or the repeats of a dose.

The invention relates to an injection unit, preferably a pen-shaped injection unit, for administering or delivering a fluid product. The injection unit comprises a housing, an axially movable piston rod mounted in the housing in a non-rotatable manner, a delivery apparatus having a threaded nut that is able to move the piston rod in order to deliver product, a dosing device having a dosing sleeve, a rotary knob, a discharge button arranged coaxially on the dosing sleeve, and a receptacle for the product. The dosing device is connected to the delivery apparatus via a coupling mechanism, wherein the coupling mechanism includes of at least two coupling surfaces that each carry a toothing comprising teeth, wherein the coupling surfaces are used to generate an acoustic and/or tactile signal corresponding to the set or corrected dose of the product to be administered during the dosing operation or during correction of the dose.

An assembly for a drug delivery device comprises: a housing having a proximal end and a distal end, a dose setting and drive mechanism comprising a dose setting member moveable relative to the housing in a dose setting operation from an initial position to a dose set position, the dose setting and drive mechanism further comprising a piston rod displaceable in the distal direction relative to the housing in a dose delivery operation, wherein, during the dose delivery operation, the piston rod is displaced relative to the housing by a displacement distance which is determined by the set dose, a guide track, a tracking member configured to cooperate with the guide track, and a coupling mechanism configured to operatively couple the tracking member to the dose setting and drive mechanism, wherein the coupling mechanism has a coupled state and a non-coupled state.

A system for medication delivery comprises a package containing a medication and a dosing device for delivering a dose of the medication, formulated as a multiparticulate, microspheres, a powder or a liquid. The package comprises a bottle, a bottle insert that covers a bottle opening and includes a dispense nozzle. The dispense nozzle is sealed using a valve that opens when the dosing device is engaged with the bottle. A closure covers the bottle insert and closes the bottle. The dosing device, similar to an oral syringe, comprises a barrel with a valve at a distal end of the barrel, a plunger and a dose control clip for attachment to the plunger. After the dosing device is connected to, the valve of the dispense nozzle, withdrawal of the plunger causes the dosing device to receive the dose of the medication, a user pushes the plunger which pushes the medication through the valve of the barrel and into a patient's mouth.

Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

An assembly for a drug delivery device comprises a housing, a dose member which is displaceable in a proximal direction with respect to the housing for setting of a dose of a drug, a clutch member which is displaced in the proximal direction with respect to the housing when setting the dose, and a stop member configured to define a clutch stop position. The clutch member and the dose member are configured to mechanically cooperate with one another when the clutch member is in the clutch stop position, thereby preventing further displacement of the dose member in the proximal direction with respect to the housing during setting of the dose.

The present disclosure is generally directed to a clicker arrangement for use in a drug delivery device, i.e. a handheld injection device for selecting and dispensing a number of user variable doses of a medicament. The clicker arrangement comprises a first element rotatable at least in a first direction and a second, non-rotatable element. The first element is axially displaceable relative to the second element between a first position and a second position. One of the elements comprises a clicker arm and the other comprises a protrusion wherein upon rotation of the first element in the first direction relative to the second element the clicker arm is elastically deflectable in a radial direction by the protrusion and relaxable in the opposite radial direction upon disengagement with the protrusion thereby generating an audible and/or tactile feedback signal.

A dose setting mechanism is provided that includes a dose knob, a dose selector, a radial projecting rib and a snap element. The radial projecting rib is positioned circumferentially on an inside surface of the dose selector. The snap element includes a protrusion. The protruding rib has a reduced section that allows the protruding rib to move axially relative to the protrusion to initiate dose delivery.

An injection device includes an elongated housing extending along a longitudinal axis and having a distal end and a proximal end, a dose tracker being at least one of translationally or rotationally displaceable relative to the housing and being displaceable between a zero dose positional state and a maximum dose positional state relative to the housing, the positional states indicating a dose, wherein one of the elongated housing and the dose tracker includes at least one tracking stop feature, and a preselector displaceable relative to the housing between at least two preselection positional states thereby defining the maximum dose positional state of the dose tracker, wherein the preselector includes at least one preselector stop feature configured to mechanically engage with the at least one tracking stop feature to block a displacement of the dose tracker beyond the maximum dose positional state.