An apparatus includes a syringe body and a plunger. The syringe body defines a volume configured to contain a medicament. A proximal end portion of the syringe body includes an engagement portion, and a distal end portion of the syringe body includes a delivery tip. A side wall of the syringe body includes a transparent window. The plunger has a distal end portion configured to move within the volume of the syringe body to convey the medicament. An engagement portion of the plunger is configured to interface with the engagement portion of the syringe body to limit rotation of the plunger about a longitudinal axis of the plunger. An outer surface of the plunger includes a series of indicia, at least one which is visible through the transparent window.

A drive member for driving a piston rod in a drug delivery device is provided. The drive member is configured to be driven in a rotational movement by an actuating member. The drive member comprises a track for transmitting a driving load from the actuating member to the drive member. The track comprises both sections running in a distal and sections running in a proximal direction of the drive member. Moreover, a drug delivery device comprising such a drive member is provided.

An assembly for a drug delivery device comprises a drive member which is adapted and arranged to be displaced in a dose setting direction for setting a dose of a drug and to be displaced in a dose delivery direction for delivering the set dose of the drug. The assembly comprises a piston rod which is adapted and arranged to be displaced in the dose delivery direction via mechanical interaction with the drive member for delivering the set dose. The assembly comprises at least one resilient pre-delivery element, wherein the assembly is configured such that the resilient pre-delivery element is biased when the drive member is displaced in the dose setting direction for setting the dose, the biased resilient pre-delivery element relaxes before the drive member is displaced in the dose delivery direction for delivering the dose. When the resilient pre-delivery element relaxes, the piston rod is displaced with respect to the resilient pre-delivery element in the dose delivery direction by a pre-delivery distance. Furthermore, a piston rod is provided.

A method of providing and/or injecting octreotide acetate to a subject in need thereof includes storing the octreotide acetate in a cartridge of a multi-use multi-dose injector provided with a variable dose setter and actuator. The injector includes a needle configured for subcutaneous administration of the octreotide acetate, the octreotide acetate having a concentration of 2,500 g/mL. The method further includes permitting setting of a dose of the octreotide acetate by rotation of the variable dose setter. The injector is configured to provide at least one audible feedback during the rotation. The method further includes operating the actuator to deliver the octreotide acetate from the cartridge through the needle to treat the subject. The injector is provided with multiple surface portions.

Medication delivery devices, sensing systems, and methods are disclosed for determining the relative axial and rotational movements of its members to determine the amount of a dose set and/or delivered by the medication delivery device. A sensing system comprises a barrel sensor system, a drive sleeve sensor system, and/or an axial sensor system. The barrel sensor system is for detecting the absolute relative angular position of the barrel relative to the housing during dose setting. The drive sleeve sensor system is for detecting the absolute relative angular position of the drive sleeve relative to the housing during dose delivery. The axial sensor system is for detecting the relative axial positions of the dose dial relative to the housing during dose setting and delivery. A controller receives outputs from the sensor systems corresponding to the absolute relative positions to determine the actual amounts of dose set and delivered.

A dose delivery mechanism includes a housing, a piston rod to act on a plunger sealing a fluid compartment and to move in an axial direction relative to the housing to deliver a set dose, and a dose setting member movable relative to the housing during dose setting. A position of the dose setting member relative to the housing defines the set dose, and in an as-delivered condition, the dose setting member is preset to a position that corresponds to a set dose higher than zero.

A precise dose syringe for medical botulinum toxin is provided, which includes a syringe and a plunger handle. Multiple arc-shaped grooves are respectively provided on both sides of the plunger handle, and a scale line is processed on the front side of the plunger handle. A reminder mechanism and a quantitative mechanism are sleeved on the outer side of the plunger handle. The indicator arrow is located in front of the plunger handle, and the I-shaped block is connected to a thumb screw. The front side of the thumb screw is fixedly connected to a contact block, and the front side of the contact block is in contact with a back side of the plunger handle. The quantitative mechanism can make the injection dose of the syringe precise and controllable, while the reminder mechanism can remind doctors of the real-time injection amount during botulinum toxin injection.

Devices for delivery of individual units of a medicament and methods for their use are provided. Such a delivery device comprises an exostructure permanently attached to a syringe comprising a barrel and a plunger with one or more ratchet surfaces, a cam mechanism to advance the plunger a plurality of set distances in a first direction to deliver a single individual unit of the medicament per each set distance, and a locking pawl to prevent the plunger from being retracted in a second direction opposite the first by interfacing with the ratchet surfaces. The locking pawl also produces tactile feedback, audible feedback, or both when the plunger is depressed to advance the plunger the set distance. Each of the individual units comprise a measured volume of the medicament, and the plunger can repeatedly be depressed and repeatedly engage with the locking pawl to deliver repeated measured volumes of the medicament.

A drug delivery device includes a mechanism unit comprising a housing element, an interface feature for releasably connecting with a drug reservoir unit, and a locking mechanism with a first movable element being movable relative to the housing element between a first position and a second position. The mechanism unit is configured to enable a dispense process for dispensing a drug dose. The locking mechanism is switchable between released and locked states. When the first movable element is in the first position, the locking mechanism is in the released state and, when the first movable element is offset from the first position, the locking mechanism is in the locked state. In the locked state, the drug reservoir unit connected to the mechanism unit cannot be separated from the mechanism unit. In the released state, the locking mechanism enables separating the drug reservoir unit from the mechanism unit.

A precise dose syringe for medical botulinum toxin is provided, which includes a syringe and a plunger handle. Multiple arc-shaped grooves are respectively provided on both sides of the plunger handle, and a scale line is processed on the front side of the plunger handle. A reminder mechanism and a quantitative mechanism are sleeved on the outer side of the plunger handle. The indicator arrow is located in front of the plunger handle, and the I-shaped block is connected to a thumb screw. The front side of the thumb screw is fixedly connected to a contact block, and the front side of the contact block is in contact with a back side of the plunger handle. The quantitative mechanism can make the injection dose of the syringe precise and controllable, while the reminder mechanism can remind doctors of the real-time injection amount during botulinum toxin injection.