A medication delivery device is disclosed including a rack-and-pinion plunger drive system. The drive system includes an output drive having a pawled end movably coupled with the ratchet teeth of the plunger, and a pinion drive coupled between the housing, the output drive and an actuator. Actuator is longitudinally movable between dose set and delivery positions. Movement of the actuator causes rotation of the pinion drive along the rack to translate the output drive member with the pawled end that is engaged with the plunger ratchet teeth to distally advance the plunger. The device may include one or more of an end of dose mechanism to limit travel of the actuator, a load brake system to stop travel of the plunger under high input forces, a dose detection system, and a dose selector to vary the amount of dose set.

An injection device comprises a housing with a receptacle for the product, a dosing mechanism for setting a product dosage, a dispensing mechanism for dispensing the product, at least one sleeve, which is rotatable relative to the housing in order to eject the set product dosage, and a stop wheel coupled to the at least one sleeve such that the stop wheel is rotatable relative to the housing and the at least one sleeve for setting a product dosage and together with the at least one sleeve relative to the housing in order to eject the set product dosage. The device further comprises a first detector for detecting movement of the stop wheel relative to the housing and/or the at least one sleeve and a data processing unit connected to the first detector reading, storing, processing, transmitting, and/or displaying signals received from the first detector.

A medication injection device comprising a medication container to contain medication; a connector provided with a blocking feature; a push rod having a plurality of teeth disposed along the length, and a spring biasing against the push rod to move proximally. The spring can be compression spring, extension spring, torsion spring, or constant force spring. By enabling or disabling engagement between the blocking feature on the connector and the tooth on the push rod, the push rod is either prevented from moving distally or allowed to move distally. The medication is drawn into the medication container when the push rod moves proximally and the medication is dispensed out of the medication container when the push rod moves distally.

Disclosed is an applicator comprising or including, a dosing body including, at least one barrel; a piston moveable within the at least one barrel to stroke between a variable first position and a second position. In use, movement of the piston towards the first position can draw a first fluid into the barrel, and movement of the piston towards the second position can force the first fluid out of the barrel. There is at least one fluid inlet valve to allow the fluid to flow into the at least one barrel at least under action of the piston, and at least one fluid outlet valve to allow the first fluid to flow out of the at least one barrel at least under action of the piston. A piston actuating assembly, selectively engageable with the dosing body, is present, the piston actuator assembly having a user operable handle to drive a second actuation member which in turn can drive the piston between the first position and the second position, the connection between the second actuation member, or part thereof being a releasable one.

A kit is disclosed for accurately loading a small volume dose of a medication within a syringe and for delivering the small volume dose of the medication at a treatment site. The kit generally includes a loading and delivery system in accordance herewith, a syringe, and a medication. The loading and delivery system includes a syringe delivery ring and a syringe loading guide, which may be used for example, to administer a small volume dose of a medication at the end of an ocular surgery.

The disclosure provides driver components, systems and drive methods that facilitate improved dose setting, correcting, and/or dispensing in a multiple use pen-type injection device. In particular, various novel braking systems are disclosed that can be implemented within pen-type injection devices to achieve such improvements.

A medication injection pen comprises a dose set knob rotatable with respect to a housing to set a desired injection dose. The dose set knob comprises at least one internal thread. A leadscrew includes a thread element for advancing in a first direction via a corresponding thread engagement. A driver is rotationally fixed to the leadscrew and is rotatable in a first direction to rotate and advance the leadscrew in the first direction. The setback member is rotationally fixed to the driver. The dose stop member is rotationally coupled to the setback member and is axially movable relative to the dose set knob when the dose set knob is rotated relative to the setback member. Axial movement of the dose stop member limits the user from setting a dose that is greater than an injectable volume of medication remaining in a cartridge.

A medication injection pen comprises a dose set knob rotatable with respect to a housing to set a desired injection dose. The dose set knob comprises at least one internal thread. A leadscrew includes a thread element for advancing in a first direction via a corresponding thread engagement. A driver is rotationally fixed to the leadscrew and is rotatable in a first direction to rotate and advance the leadscrew in the first direction. The setback member is rotationally fixed to the driver. The dose stop member is rotationally coupled to the setback member and is axially movable relative to the dose set knob when the dose set knob is rotated relative to the setback member. Axial movement of the dose stop member limits the user from setting a dose that is greater than an injectable volume of medication remaining in a cartridge.

An injection device is for automatically squeezing injection liquid from a container and includes: a housing; an injection spring configured to cause squeezing of the injection liquid from the container; the injection device defining a longitudinal central axis and a proximal direction; a metering piston mounted so as to be movable in the direction of the longitudinal central axis of the injection device; the metering piston being configured to, when squeezing injection liquid, move in the proximal direction; a setting device for setting the quantity of injection liquid to be squeezed; an end stop which establishes a terminal position of the metering piston; and, the setting device having an adjustment unit configured to adjust the position of the end stop.

Devices and methods for intraocular fluid injection are disclosed. A device can include a surgical instrument for an ophthalmic procedure. The surgical instrument can include a handle. A fluid compartment can be coupled to the handle and configured to hold a substance. A tool can be coupled to the distal end of the handle and have a lumen configured to convey the substance into an intraocular site of a patient. A piston can be in the handle and configured to reciprocate along the longitudinal axis of the handle to draw the substance from the fluid compartment and eject the substance through the lumen of the tool. A push button can be on the lateral side of the housing and configured to engage the piston via a sloped surface to actuate a forward stroke of the piston towards the distal end of the handle.