A method of manufacturing one of a range of autoinjectors having cartridges (600, 600′, 600″) with different preset fill volumes, the method comprising the steps of: a) providing a front body assembly (100b, 100c, 100c′, 100c″), b) providing a cartridge (600, 600′, 600″) of given fill volume, c) providing a rear body assembly (100a) comprising a spring-driven drive ram assembly (310, 320) configured to drive the piston of a held cartridge (600, 600′, 600″), d) providing a ram spacer member (400, 400′, 400″), the ram spacer member defining a spacing geometry of length dimension (X1′, X1″, X1′″, XS′, XS″, XS′″, XR′, XR″, XR′″) selected according to the fill volume of the cartridge (600, 600′, 600″), and e) assembling a front body assembly (100b, 100c, 100c′, 100c″), the cartridge (600, 600′, 600″), the ram spacer member (400, 400′, 400″) and the rear body assembly (100a) so that the ram spacer member (400, 400′, 400″) is arranged axially between the drive ram assembly (310, 320) of the rear body assembly (100a) and the piston of a held cartridge (600, 600′, 600″).

A dose setting mechanism comprising a first element and a second element; the first element being moveable with respect to the second element; the first element and the second element being coupled by a ratchet mechanism allowing motion of the first element with respect to the second element from a first position to a second position only in a first direction while preventing motion in a second direction that is opposite to the first direction; once passing the second position, the first element being moveable with respect to the second element in the first direction and in the second direction.

The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.

A piston rod is arranged in a body and provided with a helical element and an axial element. A guide element, which is arranged in the body and fixed relatively to the body, is coupled to the helical element to guide a helical movement of the piston rod and coupled to the axial element to guide an axial movement of the piston rod. The axial movement allows a priming of the device preceding the helical movement of the piston rod.

A drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing, a dose setting element rotatable relative to the housing during dose setting and dose dispensing, a drive member coupled to the dose setting member via a clutch, and a piston rod coupled to the housing and to the drive member. Further, the device further comprises a cartridge holder removably attached to the housing and a reset element, which is axially constrained to the dose setting element, and at least one spring acting on the reset element, such that, if the cartridge holder is detached from the housing, the reset element is axially moved relative to the housing onto a position in which the dose setting element is rotationally constrained to the housing and the drive member is allowed to rotate relative to the housing.

An assembly for a drug delivery device is provided comprising a housing, a cartridge holder releasably connectable to the housing, a resilient member, and an interaction member which is configured to mechanically cooperate with the resilient member and with the cartridge holder. The resilient member is configured to rotationally bias the interaction member. The assembly has a locked state where the cartridge holder is connected to the housing, the cartridge holder being obstructed from movement with respect to the housing, and an unlocked state where the connection between the cartridge holder and the housing is released, the cartridge holder being freely moveable with respect to the housing.

A drive assembly for a medication delivery device is provided, comprising a piston rod which is movable from a start position to an end position for medication delivery and resettable from the end position to the start position. The drive assembly further comprises an impeding element for impeding a movement of the piston rod from the end position to the start position during a reset of the piston rod, wherein the impeding element comprises at least one resilient element. Furthermore, a medication delivery device comprising the drive assembly is disclosed.

A method for assembling a drive spring, especially into a drug delivery device includes rotating a component part to which the drive spring is attached in a first direction, followed by a rotation of the component part in the opposite direction and followed by attachment of a rotational stop. Further, the disclosure includes a drug delivery device for selecting and dispensing a number of user variable doses of a medicament, which device comprises a pre-charged drive spring.

A dose setting mechanism for a drug delivery device is provided comprising a dose setting member and a further element. Maximum dose stop features are provided on a housing and on the further element.

An assembly for a drug delivery device is provided comprising a screw member comprising a thread, the thread including at least two consecutive portions, the portions having different leads. The device further includes a nut member. The assembly is configured such that, in a first portion of the thread, the nut member includes a first position with respect to an axis transversal to the rotational axis and in a second portion of the thread, the nut member includes a second position with respect to the axis transversal to the rotational axis. The nut member is configured to perform a tilting movement from the first position into the second position when the nut member passes from the first portion to the second portion. Furthermore, a drug delivery device comprising the assembly is described.