According to some embodiments, a syringe may include a barrel; a delivery conduit; a plunger seal disposed within the barrel; and a plunger rod assembly affixed to an end of the barrel, the plunger rod assembly including a first plunger rod component comprising a first linear gear, a second plunger rod component disposed at least partially in the barrel and engaged with the plunger seal, wherein the second plunger rod component comprises a second linear gear, a first rotational gear having a plurality of gear teeth for engaging the first linear gear, and a second rotational gear having a second plurality of gear teeth for engaging the second linear gear, wherein the first rotational gear is coupled to the second rotational gear such that translation of the first plunger rod component causes translation of the second plunger rod component.

A drive mechanism for an applicator for delivering a dose of a medicament, comprising: a dose setting assembly (N), a knob (1), a rotatable and axially non-translatable clutch element (2) coupled in rotation with the knob (1) and cooperating with the dose setting assembly (N), a rotatable piston rod (3) having an external thread (3.2), the piston rod (3) being located inside the clutch element (2), a drive element (4) and a drive spring (5), wherein when a dose is being set (1) by means of the knob (1), the clutch element (2) is rotated so that the drive spring (5) is loaded, while the drive element (4) and the piston rod (3) are immobilized, and when the dose is being delivered, the drive spring (5) is being released causing the drive element (4) to rotate together with the piston rod (3), the piston rod (3) being moved axially in a distal direction, wherein the piston rod (3) is hollow and has an internal thread (3.3) and a shaft (21) having an external thread (21.2) is located within the piston rod (3), the shaft (21) being engaged in rotation with the clutch element (2) so that during the setting of each subsequent dose the shaft (21) is rotated in relation to the piston rod (3) and moved axially in a proximal direction, while during the delivery of the dose the shaft (21) is immobilized in relation to the piston rod (3), and wherein the total translation of the shaft (21) in relation to the piston rod (3) caused by the setting of a defined number of doses is limited by means of blocking elements (B) located respectively on the piston rod and the shaft. An applicator for delivering a dose of a medicament, the applicator comprising the disclosed drive mechanism.

A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove and a helical spline. The inner housing helical spline guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.

The present disclosure relates to a dosing mechanism for a drug delivery device for selecting and dispensing a number of user-variable doses of a medicament. The dosing mechanism comprises a housing, a piston rod, and a driving mechanism for rotating the piston rod and/or a movement application component, which is directly engaged with the piston rod, in a dispense rotational direction with respect to the housing for dose dispense. The dosing mechanism further comprises a rotational end stop mechanism for terminating dose dispense with a first engagement means, which is rotationally fixed with respect to the piston rod and/or the movement application component, and a second engagement means, which is prevented from rotation with respect to the housing in the dispense rotational direction at an end of dose dispense. In order to improve the dose delivery accuracy, the second engagement means directly engages the first engagement means. disclosure

A medicine injection pen includes a rotatable drive member and a rotary encoder associated with the drive member. The rotary encoder is configured to determine an amount of liquid medicine dispensed based on a rotational orientation of the drive member.

A medication injection method where a dose set knob of a medication injection pen is rotated with respect to the housing of the medication injection pen during dose setting and dose correcting, a driver is selectively engages with the dose set knob, the driver being rotatably fixed with respect to the housing during dose setting and dose correcting, the driver is moved axially with the dose set knob during the dose setting and the dose correcting, and the driver is rotated with the dose set knob during an injection.

A dispensing mechanism for delivering a dosage of medicament including a housing, a push button, a crank arm that is slideably engageable with the push button, a ram, and a ratchet gear releasably engageable with the crank arm and ram, translation of the push button along an axis causing the crank arm to engage and rotate the ratchet gear which causes the ram to distally advance relative to the housing.

The present invention relates to a delivery device for delivering predetermined amounts of fluid, comprising a body (10), a container (16) filled with fluid to be delivered arranged inside said body, said container comprising an opening for expelling said fluid and a wall (18) movable inside said container (16), a threaded plunger rod (46) arranged movable inside said body (10) in the longitudinal direction and in contact with said movable wail (18), a manually operated push means (14, 60) movable in the longitudinal direction capable of, upon operation, move said plunger rod (46) towards said movable wall (18), thereby expelling fluid, and means for transforming a generally linear movement of said push means (14, 60) to a rotational movement of said plunger rod (46).

The present disclosure relates to a dose detection system for use with a medication delivery device in which a dose setting member rotates relative to an actuator during dose delivery. The dose detection system comprises a module including a rotation sensor attached to the actuator during dose delivery. A sensed element is attached to the dose setting member and includes first gear teeth. The rotation sensor comprises a driven gear including second gear teeth. The second gear teeth are operatively received by the first gear teeth and are driven in rotation as the first gear teeth rotate during dose delivery. The rotation sensor is responsive to the rotation of the second gear teeth to detect the rotation of the dose setting member.

An autoinjector includes a case adapted to hold a medicament container having a needle, a needle shroud telescopically coupled to the case, and a plunger rotationally and slidably disposed in the case. The needle shroud is movable between a first extended position relative to the case in which the needle is covered and a retracted position relative to the case in which the needle is exposed. The plunger is rotatable relative to the case between a first rotational position in which the plunger is engaged to the case and a second rotational position in which the plunger disengages the case. The needle shroud is operably coupled to the plunger. When the needle shroud translates from the first extended position to the retracted position, the plunger rotates from the first rotational position to the second rotational position.