The present invention provides actuation mechanisms that incorporate a transmission assembly that allows the mechanisms to cause actuation of workpieces according to a plurality of transmission modes (e.g., at least one forward transmission mode and at least one reverse transmission mode) on demand. Motion, direction, and/or force can be controlled by selecting the corresponding transmission mode. The mechanisms preferably are trigger-actuated by hand (i.e., manually) to cause movement of a workpiece in a desired direction. Desired directions can be linear or nonlinear. The same hand used for trigger action can also be used to change transmission modes in many modes of practice, even while using substantially the same grip used for trigger actuation. In other instances, actuation can be automated rather than manual. Preferably, both actuation and witching among transmission modes can be accomplished with one hand, even while maintaining substantially the same grip that is used for actuation.

Provided is a syringe pressure generating and pressure displaying device applied to a syringe configured such that an auxiliary device is detachably attached to the cylinder flange while the rod bar is installed in the auxiliary device so as to pass therethrough, and a grip of the hand on a lever that is hinge-connected to the auxiliary device so as to be disposed horizontally in line with the syringe creates a rotational motion due to leverage, whereupon the rotational motion is converted into a linear motion via a motion-converting means, and the rod bar and the piston are moved with increased force.

The invention refers to an injection device comprising a housing (10), containing a cartridge (170) with an amount of liquid to be dispensed, a drive sleeve (41), which is rotationally constrained to the housing (10) during dose setting and spring driven rotatable relative to the housing (10) during dose dispensing, a dose dial member (60) for setting a dose to be dispensed, which is rotatable relative to the housing (10) during dose setting and during dose dispensing, and which is rotationally coupled to the drive sleeve (41) during dose dispensing. The device further comprises a last dose protection mechanism (41, 50, 60) for preventing the setting of a dose, which exceeds the amount of liquid left in the cartridge (170), with a limiter (50), which is interposed between the drive sleeve (41) and the dose dial member (60). Further, the device comprises two different display members (110, 120), each indicating the set dose.

An autoinjector includes a case adapted to hold a medicament container having a needle, a needle shroud slidably disposed in the case and translatable between an extended position relative to the case in which the needle is covered and a retracted position relative to the case in which the needle is exposed, and a plunger slidably disposed in the case. The case includes a rib. The plunger includes a plunger boss adapted to abut the rib and the needle shroud when the needle shroud is in the extended position and disengage the rib when the needle shroud is in the retracted position to allow the plunger to translate axially relative to the case.

A drive assembly for a drug delivery system includes a plunger member configured to engage and move a stopper within a container, with the plunger member having a first position and a second position axially spaced from the first position, a leadscrew configured to move the plunger member from the first position to the second position, and a biasing member configured to bias the leadscrew in a rotational direction, where rotational movement of the leadscrew is configured to move the plunger member from the first position to the second position.

Disclosed herein are exemplary medical devices for delivery of compositions. Medical devices disclosed herein comprise components for the intake of one or more compositions through one port so that little to none of the composition is lost within the device because the composition is then delivered out the same port throughwhich the composition was drawn into the device.

A medical device comprising an enclosure defining a cavity for containing agent, a lumen for receiving a pressurized gas, and a barrier positioned between the cavity and the lumen, the barrier including at least one opening for storing agent, wherein rotation of the barrier relative to the lumen establishes fluid communication between the at least one opening and the lumen for delivering agent from the at least one opening to the lumen.

A dual chambered syringe includes: an inner barrel defining a first inner chamber, the inner barrel having an apertured stopper at its distal end, the inner barrel being open at its proximal end; a shaft adapted to fit within the inner barrel, the shaft having a distal end which is engageable with the aperture of the stopper; a device for controlling engaging and disengaging of the distal end of the shaft with the aperture of the stopper; an outer barrel concentric with the inner barrel defining a second inner chamber, the outer barrel having a distal end for receiving and dispensing fluids and a proximal end into which the distal end of the inner barrel is insertable into the second inner chamber; the apertured stopper engages the second inner chamber of the outer barrel and selectively prevents or permits the passage of fluids between the outer barrel second chamber and the inner barrel first chamber; the inner barrel having an engageable surface on its outside surface; and, the outer barrel having operatively associated therewith an engaging device for selective engagement and disengagement with the engageable surface on the inner barrel.

A method and system are disclosed for driving a plunger in a drug reservoir. In some embodiments, a variable friction element interconnects between a pushing shaft and a wall of the reservoir. For example, rotation of a driving element in a first direction relative to the pushing shaft may advance the pushing shaft in the reservoir. The friction element may have increased friction resistance to rotation of the pushing shaft in the first direction in comparison to frictional resistance to advancing the pushing shaft. For example, the increased friction may result from wedging a radial element between the pushing shaft and the wall of the reservoir.

A pre-filled syringe for sterile medication fluid injection includes a syringe barrel with rotationally symmetric cylindrical bore, having a distal end and a proximal end; a syringe piston with rotationally symmetric external shape; a backstop mounted at the proximal end of the syringe barrel with an opening that is rotationally asymmetric about the axis through the syringe barrel; a push rod to move the syringe piston inside the syringe barrel, wherein at least one portion of the push rod is rotationally asymmetric about the axis through the syringe barrel, and upon rotation, the rotationally asymmetric portion of the push rod is aligned with the rotationally asymmetric opening of the backstop; and a seal component to cover the distal end of the syringe barrel.