The present disclosure relates to an injection needle assembly for use in a medicament delivery device. The injection needle assembly comprises an injection needle holder, an injection needle fixed to said injection needle holder, the injection needle having a proximal end and a distal end, and a sealing assembly for sealing the distal end of the injection needle. The sealing assembly comprises a spacer element surrounding the distal end of the injection needle and a sealing membrane for sealing the distal end of the injection needle.

A method of manufacturing one of a range of autoinjectors having cartridges (600, 600′, 600″) with different preset fill volumes, the method comprising the steps of: a) providing a front body assembly (100b, 100c, 100c′, 100c″), b) providing a cartridge (600, 600′, 600″) of given fill volume, c) providing a rear body assembly (100a) comprising a spring-driven drive ram assembly (310, 320) configured to drive the piston of a held cartridge (600, 600′, 600″), d) providing a ram spacer member (400, 400′, 400″), the ram spacer member defining a spacing geometry of length dimension (X1′, X1″, X1′″, XS′, XS″, XS′″, XR′, XR″, XR′″) selected according to the fill volume of the cartridge (600, 600′, 600″), and e) assembling a front body assembly (100b, 100c, 100c′, 100c″), the cartridge (600, 600′, 600″), the ram spacer member (400, 400′, 400″) and the rear body assembly (100a) so that the ram spacer member (400, 400′, 400″) is arranged axially between the drive ram assembly (310, 320) of the rear body assembly (100a) and the piston of a held cartridge (600, 600′, 600″).

The present invention involves a sterilizable syringe allows for reduction in needlestick injuries using conventional sterile needles. The syringe allows for direct access to and the safe removal and disposal of needles. The device consists of a sterilizable, reusable hypodermic syringe to which a disposable needle is attached, and employs carpules containing injectable medication, viewable and either manually or automatically aspirating. Some embodiments have a protective sliding mechanism consisting of an open frame bearing one or more protective collars, one at the furthermost end of the frame and an optional second one at a more proximal position. The protective mechanism may be extended to protect an exposed needle tip and retracted during an injection. With the protective mechanism extended, the needle mounting hub is exposed to allow for its exchange or removal and safe disposal. The protective mechanism is engaged until immediately prior to the delivery of medication, disengaged on delivery, and engaged after delivery.

The present invention relates to a needle cover assembly to be used with a medicament delivery device, wherein said needle cover assembly (10) is disposable and comprises a retainer element (50) connectable to the medicament container holder; a hub (16) having a longitudinal axis and comprising a double pointed injection needle (22) with a proximal needle end (24) and a distal needle end (48), wherein the proximal needle end projects a distance from the hub (16) along the longitudinal axis, and a shield (18) covering at least the proximal needle end and a portion of the hub (16). The invention is characterised in that said shield (18) comprises a detachable element (26), that the shield (18) is attached to the hub (16) when said detachable element (26) is attacked to the shield (18), corresponding to an untampered state, and that the shield is released and is telescopically movable in relation to the hub (16) along the longitudinal axis when said detachable element (26) is detached from the shield (18) corresponding to an activated state.

Devices, systems, and methods for performing injections with lowered likelihood of infection include catheters and other injection means with protective coverings. The protective covering can protect the catheter or other injection means before, during, or before and during insertion of the catheter into an insertion site. The protective covering includes two or more parts of interlocking protrusions and channels that allow for sliding motion of the parts relative each other but that resist separation of the parts in the direction perpendicular to the long axis of the two or more parts.

A safety syringe for medical use having an injection molded plastic body with a tubular barrel, a transverse finger flange surrounding the barrel and two upwardly projecting wings with substantially flat, outwardly facing surfaces disposed forwardly of the finger flange, a plunger assembly slidably engaging an inside wall of the barrel, a needle with a tip projecting forwardly from the barrel, and a needle safety shield slidably engaging the body between the wings, wherein the transverse finger flange has a window that allows core pin insertion through the window during injection molding of the body, the plunger assembly has a proximal end cap that is integral with the plunger handle and abuts a rearwardly facing surface of the transverse finger flange, and the needle safety shield has a distal end with a cylindrical needle guard that is forwardly movable following use of the syringe to guard the needle tip.

A segmented safety cover may include a proximal segment combined with a needle hub; a needle cannula that extends from the proximal needle hub to a distal sharpened end; a distal end cap with a hollow bore through which the needle cannula passes; a centrally mounted toggle locking mechanism, separating the proximal needle hub from the distal end cap; the toggle locking mechanism is torsion spring assisted; a proximal cover segment is connected to the hub via a proximal hinge and a distal cover segment is connected to the end cap via a distal hinge; said proximal cover segment and said distal cover segment of said toggle locking mechanism being configured with abutting faces when the segmented safety cover is in a safety mode; and wherein the proximal hinge, abutting faces and distal hinge are in line in the safe mode.

An injection device, method, and system for drug delivery includes a container for storing a drug, the container having a stopper movably disposed in the container for expelling the drug; an injection drive mechanism having a plunger for acting on the stopper and an energy source having a first selected potential energy for exerting a force on the plunger to cause the plunger to act on the stopper to expel the drug; and a plunger loading mechanism for substantially preventing the plunger from accelerating to a predetermined velocity before it acts on the stopper. The plunger loading mechanism may be a spring having a second selected potential energy for reducing or eliminating a distance between the plunger and the stopper, prior to the plunger accelerating to the velocity. The second selected potential energy of the spring may be less than the first selected potential energy of the energy source.

The present invention relates to a medicament delivery device comprising: a housing (10, 16) having a distal and an proximal end, said housing being adapted to receive a medicament container (18) with a delivery member (20) or with a connectable delivery member for delivery of a medicament; a drive mechanism (54) arranged to act on a plunger rod (58), which plunger rod (58) in turn is arranged to act on the medicament container (18) for providing automatic delivery of the medicament; a release mechanism (62) interactively connected to the drive mechanism (54) for releasing the drive mechanism (54) from a pre-tensioned state; a signal generating mechanism (90) for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely delivered, which signal generating mechanism (90) is operably connected to said drive mechanism such that it is arranged movable in a longitudinal direction in relation to said drive mechanism (54), that said drive mechanism (54) is arranged with a signal release mechanism (111) capable of activating said signal generating mechanism (90) at a certain longitudinal position of said drive mechanism after its release, for generating an audible and/or tactile and/or visual signal, wherein said signal generating mechanism (90) comprises a signal delay mechanism (105) operably arranged to delay the generation of signal after activation of said signal generating mechanism (90).

For use in an injection device, e.g., an auto-injector of any type, a sleeve which holds the medicament chamber is sufficiently deformable that it functions as a shock absorbing member to distribute the force exerted on the medicament chamber during use of the injection device.