Embodiments relate to an implantable device. Specifically, a device includes a flexible connection component that includes a set of conductive filaments that connect a set of electrodes (or traces connected to the electrodes) and circuitry that receives and/or transmits electronic signals from and/or to the electrodes.

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.

An improved electroporation probe that delivers both electroporation and medicinal solution injection via a single instrument, and which allows altering of the applied electric field based on requirements of the target, is disclosed. A proximal end of a hollow tubular probe is connected to an injector for injecting medications, cells, proteins or biologics in solution into the probe, and which in turn are ejected through unsealed perforations on a perforated portion of the probe towards its distal end. A movable sleeve is slidable over the perforated portion of the probe in order to seal or unseal its perforations. A tapered metallic tip at the distal end of the probe is connected to an anode terminal of a battery, the distal end of the movable sleeve is connected to a cathode terminal of the battery. Separation between the tip and the distal end of the movable sleeve is varied to generate desired strength of the electric field needed for electroporation of target cells, or to selectively unseal more or fewer perforations for medicinal solution delivery at the target.

A flexible electrode includes a flexible, electrically insulative substrate, a bonding layer disposed on a first surface of the substrate, a conductive layer disposed on a second surface of the substrate, and a via through the bonding layer and the substrate that exposes a portion of the reverse surface of the conductive layer. The exposed portion of the reverse surface can be secured (e.g., soldered) to a conductive contact, such as a conductive pill, on an exterior surface of a catheter shaft. The flexible electrode can then be wrapped around the exterior surface of the shaft to form a ring electrode and the bonding layer can be bonded to the catheter shaft, such as by reflow bonding.