An electrode for electroporation comprising a plurality of electrode needles, wherein first polarity electrode needles, an electrode needle holding portion, and a syringe holding portion are provided; two or more first polarity electrode needles project from a bottom surface of a lower structural body of an outer frame support of the electrode needle holding portion toward an electroporation target side; the bottom surface of the lower structural body of the outer frame support is provided with a hole for syringe needle insertion and removal communicating with a syringe holding portion side; the syringe holding portion is provided on a side opposite to the electroporation target side of the electrode needle holding portion; and the syringe holding portion has a path for syringe needle insertion and removal, at least a portion of the path for syringe needle insertion and removal being provided with an electro-conductive portion for a second polarity.

The present invention relates to electroporation (EP) devices that are able to generate an electroporation causing electrical field at the mucosal! layer, and preferably in a tolerable manner. Further, it includes the generation of a protective immune response, cellular and/or humoral, using the oral EP device along with a genetic construct that encodes an immunogenic sequence.

An electrode device for use in delivery of electrical pulses to a desired tissue of a mammal. The electrode device comprises a handle portion comprising first second electrode connections, and first and second needle electrodes comprising a respective first and second attachment end. Each one of the first and second electrode connections is configured with an inner electrode position and an outer electrode position, wherein the inner and outer electrode positions are electrically conducting. Further, each one of the first and second attachment ends is configured with an insulating part configured to electrically insulate one out of the inner electrode position and the outer electrode position when located therein, and configured with an electrically conducting part configured to conduct current supplied to the other one out of the inner electrode position or the outer electrode position when located therein.

An oral appliance for the treatment of sleep disorders, such as obstructive sleep apnea, in a user is presented. The oral appliance may include a mouthpiece configured to receive a user's dentition. The mouthpiece may include an oxygen sensor, a pressure sensor, an airflow sensor, an actigraphy sensor, a noise detector, and at least one stimulator for providing stimulation to a user's tongue in the event of decreased oxygen saturation levels, increased pressure applied to occlusal surfaces of the user's dentition, decreased actual airflow levels and/or increased noise levels. The mouthpiece may be provided with pharmaceutical compound reservoirs that deliver pharmaceutical compounds to the oral mucosa of the user, which compounds treat symptoms of sleep apnea. The mouthpiece may further include a microprocessor that receives data from the oxygen sensor, pressure sensor, airflow sensor, actigraphy sensor and noise detector, and activates the at least one stimulator and/or pharmaceutical compound reservoirs.

The present invention relates to electroporation (EP) devices that are able to generate an electroporation causing electrical field at the mucosal layer, and preferably in a tolerable manner. Further, it includes the generation of a protective immune response, cellular and/or humoral, using the oral EP device along with a genetic construct that encodes an immunogenic sequence.

Disclosed herein is an implantable electronic device for use with an implantable medical lead. The implantable electronic device includes a housing and a header connector assembly coupled to the housing and adapted to receive the proximal lead end of the implantable medical lead. The header connector assembly includes a connector assembly including a connector, a feedthrough extending through the housing, and a conductor coupling the feedthrough to the connector. The conductor includes a first conductor segment and a second conductor segment offset from the first conductor segment and each of the first conductor segment and the second conductor segment are resistance welded to the connector.

Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.

To provide a biomedical electrode which is capable of restraining displacement or release of the electrode even if a living body takes a hard action, and which is mountable without an occurrence of discomfort. This biomedical electrode has conductive gels 11, 11, retaining members 12, 12 to retain the conductive gels 11, 11, and an adhesive surface 31a, and comprises a sheet-shaped adhesive member 30 to adhere the conductive gels 11, 11 to a living body surface S via the retaining members 12, 12, and further, the adhesive member 30 is formed in an enough size to cover substantially all regions of the retaining members 12, 12, and is configured to have liquid through holes 30b to 30b, 30c, 30c to discharge sweat which is accumulated in internal spaces R, R formed between the living body surface S and the retaining members 12, 12.

Disclosed herein is an implantable electronic device for use with an implantable medical lead. The implantable electronic device includes a housing and a header connector assembly coupled to the housing and adapted to receive the proximal lead end of the implantable medical lead. The header connector assembly includes a connector assembly including a connector, a feedthru extending through the housing, and a conductor coupling the feedthru to the connector. The conductor includes a first conductor segment and a second conductor segment offset from the first conductor segment and each of the first conductor segment and the second conductor segment are resistance welded to the connector.

An electrode for the electrical stimulation of brain tissue or other tissue of a patient is configured for location between skull and scalp of the patient. The electrode has a stimulation surface which is configured for contacting the skull of the patient. The electrode is a disc-shaped electrode having a pre-shaped flat or concave stimulation surface.