The invention discloses an electrochemical device for treating cancer, characterized by using an acupuncture needle as a working electrode to produce hydrogen in a tumor tissue, thereby destroying the tumor tissue through the produced hydrogen gas. The device of the invention has low cost and simple operation, can realize minimally invasive treatment, and is green and environmentally friendly.

The present disclosure relates to devices and systems for targeted and controlled delivery of a therapeutic agent to a treatment site of an eye. Particularly, aspects are directed to a therapeutic agent delivery device that includes a polymeric substrate having a release region, a delivery region, and a receiving region; one or more reservoirs formed within the release region; a therapeutic agent disposed within the one or more reservoirs; an active, passive, or combination thereof controlled release mechanism for release of the therapeutic agent from the one or more reservoirs into the delivery region; and a circuit formed on the polymeric substrate, the circuit having a current source, a first iontophoresis electrode located within the delivery region for transport of the therapeutic agent from the delivery region into a target tissue via electromigration, and a second iontophoresis electrode located within the receiving region for maintaining electroneutrality within the tissue.

The invention provides a variety of novel devices, systems, and methods of utilizing mixed-ionic-electronic conductor (MIEC) materials adapted to function with an applied current or potential. The materials, as part of a circuit, are placed in contact with a part of a human or nonhuman animal body. A sodium selective membrane system utilizing the MIEC is also described.

The invention provides a variety of novel devices, systems, and methods of utilizing mixed-ionic-electronic conductor (MIEC) materials adapted to function with an applied current or potential. The materials, as part of a circuit, are placed in contact with a part of a human or nonhuman animal body. A sodium selective membrane system utilizing the MIEC is also described.

This invention addresses the need for efficient dry skin electrodes. Robust, flexible Mixed Ionic Electronic Conductor (MIEC) electrodes were prepared by an aqueous solution route resulting in electrically conductive networks of carbon nanotubes (CNTs) and ionically conductive elastic matrix. The flexible electrode was characterized in terms of conductivity, ionic charge transfer resistance, and water uptake. The flexible electrode maintained low resistance even after multiple cycles of 50% extension and contraction.

An oral treatment device (10) for stimulating deposition of calcium phosphate from an amorphous calcium phosphate formulation in contact with a tooth (1) in an oral cavity is disclosed. The device comprises a first electrode (12) and a second electrode (14) spatially separated from the first electrode, wherein both the first electrode and the second electrode are arranged to contact the amorphous calcium phosphate formulation when the first electrode is arranged proximal to the tooth during use of the device; and the second electrode comprises a sacrificial material at least on its surface. Also disclosed is a kit of parts comprising the oral treatment device (10) and an ACP formulation and a method (100) for remineralizing a tooth using an amorphous calcium phosphate formulation.

An oral care device may include: a body including a head; a plurality of teeth cleaning elements extending from the head; a first electrode on the head; a second electrode on the head and spaced apart from the first electrode, wherein at least one of the first and second electrodes is a sacrificial electrode; a power source; and a controller configured to operably couple the power source to the first and second electrodes to create an electric potential between the first and second electrodes so that ions are released from the sacrificial electrode during a brushing session; wherein the controller is configured to change a magnitude of the electric potential the brushing session ends.

An oral care implement having electrodes thereon. In one aspect, the oral care implement may include a handle and a head, the head having a transverse through hole defined by an upper surface and a lower surface. A first electrode and a second electrode are located on the head and operably coupled to a power source to have opposite electrical charges. At least one of the first and second electrodes may be located on one of the upper and lower surfaces of the transverse through hole. In some embodiments, the first electrode is located on the upper surface of the transverse through hole and the second electrode is located on the lower surface of the transverse through hole.

Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

An electrode for electrical stimulation of tissue and administration of substances to the tissue includes a first conductive plate and a second conductive plate surrounding the first conductive plate. The first conductive plate and the second conductive plate are separated from each other. An activation signal is applied to the first conductive plate to generate an electric field inducing a current in the tissue and applying an electric potential to the second conductive plate to obtain an electric potential differential with respect to the first conductive plate. The electric potential of the second conductive plate forces the current induced by the first conductive material plate to penetrate the surface of the tissue in contact with the conductive plates and prevents the induced current from flowing on the surface of the tissue.