A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.

Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

An electrode for an iontophoretic drug delivery system includes a retainer having a malleable characteristic. The retainer and a conductor are connected to a platform. The conductor and a dose controller are electrically coupled to the iontophoretic drug delivery system. A drug delivery matrix is operably connected to the platform and proximate the conductor wherein the conductor, the drug delivery matrix, and the dose controller cooperate to deliver a drug to a user when the electrode is affixed to the user and operably connected to the iontophoretic drug delivery system.

The invention relates to an end piece intended for equipping a device for cosmetic treatment of keratin materials with an electric current, the end piece comprising an application member (6) comprising an electrode (1) and a counter electrode (2), said electrode (1) and counter electrode (2) being separated from one another by an electrically insulating zone (3).

Described is a low voltage, pulsed electrical stimulation device for upregulating expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.

A semi-dry electrode for a neural sensor net. The electrode may comprise an electrolyte storage medium for storing electrolyte, a body portion including an electrolyte reservoir for receiving the bottom surface of the electrolyte storage medium, a cap connected to the body portion for at least partially covering the top surface of the electrolyte storage medium so as to prevent contact between the top surface of the electrolyte storage medium and a person's finger(s), and a vibrating device for vibrating the electrode so as to release electrolyte from the electrolyte storage medium out through the body portion.

In order to achieve the above or other aims, according to one aspect of the present disclosure, a skin care device is provided which comprises: a body comprising a grip section for a user to hold, and a head section positioned at the end of the grip section; a plurality of skin-contacting plates positioned at the end of the head section; a plurality of oscillators for providing oscillations to each of the skin-contacting plates; and a control unit which supplies an electrical current to the skin-contacting plates and controls the oscillators, wherein the positive electrode and the negative electrode of the control unit are respectively connected to different skin-contacting plates.

A skin treatment device includes a substrate and a plurality of discrete galvanic couples provided on the substrate, each discrete galvanic couple including a first conductive electrode that is an anode and a second conductive electrode that is a cathode, wherein the anode of each galvanic couple includes a first metal and the cathode of each discrete galvanic couple includes a second metal, different from the first metal, the first and second metal having a different standard potential.

The present disclosure provides devices and methods for delivering a biomolecule into a cell. A delivery device of the present disclosure includes a first reservoir, a second reservoir, a porous membrane comprising a nanopore, and two or more electrodes configured to generate an electric field across the porous membrane for delivery of a biomolecule present in the second reservoir through the nanopore of the porous membrane and into a cell present in the first reservoir.

In one embodiment of the present invention, a method and system for the safe use of a tap-water iontophoresis machine is provided. The method is based on the specific treated zone by establishing several different treatment safety parameters according to which treated body zone is selected, such as the hands, feet, or armpits. The system includes a microcontroller, a voltage measuring module, current measuring module, polarity inversion module, and an optional resistance measuring module. The microcontroller adjusts the treatment based on the following: (a) the profile selected; (b) the values embedded in the microcontroller that is associated to the profile selected; and, (c) the values measured by the different modules and the time kept by the microcontroller. By simply choosing the treated zone, the device automatically adjusts these parameters to better reflect the specific particularities of that zone and establish often narrower ranges of values and increase safety and comfort for the patient.